Searchable abstracts of presentations at key conferences in endocrinology
Previous issue | Volume 22 | ECE2010 | Next issue

12th European Congress of Endocrinology

ea0022oc6.1 | Bone | ECE2010

A proteomic approch to study parathyroid glands

Cetani Filomena , Giusti Laura , Ciregia Federica , Banti Chiara , Da Valle Ylenia , Donadio Elena , Lucacchini Antonio , Marcocci Claudio

The molecular basis of parathyroid tumorigenesis has increased greatly over the last years and the variety of described abnormalities suggests different genetic defects leading to dysfunction of parathyroid cells. Using a combined approach based on two-dimensional electrophoresis (2DE) and mass spectrometry (MS) we performed a comparative proteome analysis to examine the global changes of parathyroid adenoma tissues protein profile with respect to the normal parathyroid tissue...

ea0022oc6.2 | Bone | ECE2010

Association between serum osteocalcin and insulin sensitivity in primary hyperparathyroidism

Gianotti Laura , Tassone Francesco , Pellegrino Micaela , Baffoni Claudia , Croce Chiara Giulia , Cesario Flora , Borretta Giorgio

A regulatory role of the skeleton on glucose metabolism has been supposed both in animals and in humans. Osteocalcin (OC) seems to be involved in this regulation and has been reported to be inversely associated with insulin resistance and measures of adiposity in different populations of adult subjects. Primary hyperparathyroidism (PHPT) is a condition mostly affecting elderly subjects and characterized by both marked increased bone turnover and increased insulin resistance. T...

ea0022oc6.3 | Bone | ECE2010

Six novel mutations in 25-hydroxyvitamin D3 1α hydroxylase gene in patients with pseudovitamin D deficiency rickets

Abeguile Genevieve , Coudray Nadia , Richard Nicolas , Linglart Agnes , Kottler Marie-Laure

Pseudovitamin D deficiency rickets also called vitamin D-deficiency rickets type 1 (VDDR 1) is an autosomal recessive disorder in which 25-hydroxyvitamin D3 1 alpha-hydroxylase gene (CYP27B1) is deficient. VDDR1 is characterized by hypocalcemia,hypophosphatemia elevated serum PTH levels and low or undetectable serum concentrations of 1,25(OH)2D.We screened for mutations CYP27B1 in ten individuals from seven unrelated families wit...

ea0022oc6.4 | Bone | ECE2010

Age-dependent features of bone mineral density changes in male rats with hyperthyroidism

Povoroznyuk Vladyslav , Gopkalova Iryna

The aim of the study was to evaluate the influence of high levels of thyroid hormones on bone mineral density in male rats as a function of experimental hyperthyroidism duration and age.Research object: Research is conducted on 56 white male rats of ‘Wistar’ breed. There were three age-dependent groups (1.5 month rats are pre-pubertal, 5–6 month are reproductive animals and 24 month – old). Animals were subdivided into 6 groups: group...

ea0022oc6.5 | Bone | ECE2010

The ratio of PTH as measured by third and second generation assays as a marker for parathyroid carcinoma

Cavalier Etienne , Daly Adrian F , Betea Daniela , Delanaye Pierre , Stubbs Phil , Bradwell Athur R , Chapelle Jean-Paul , Beckers Albert

Background: Parathyroid carcinoma (PCa) is a rare disease that can be difficult to differentiate initially from benign parathyroid adenoma. PCa over-secrete the amino form of parathyroid hormone (PTH), which is recognized by 3rd generation but not by 2nd generation (‘intact’) PTH assays. In normal individuals, the 3rd generation/2nd generation PTH ratio should always be <1.Material and methods: We studied the utility of the 3rd generation/2...

ea0022oc6.6 | Bone | ECE2010

Suppression of circulating fibroblast growth factor-23 by cinacalcet in patients with primary hyperparathyroidism

Imanishi Yasuo , Kurajoh Masafumi , Kobayashi Keisuke , Ishii Akira , Nagata Tomoki , Miki Takami , Inaba Masaaki , Nishizawa Yoshiki

While the importance of fibroblast growth factor 23 (FGF-23) is established in the pathogenesis of phosphate wasting disorders, little is known about the mechanisms regulating its circulating level. To investigate the role of parathyroid hormone (PTH) in FGF-23 homeostasis, cinacalcet hydrochloride, a calcimimetic compound to suppress PTH secretion, was administered to the patients with primary hyperparathyroidism (PHPT). Fourteen patients with PHPT, who met the guidelines of ...