Searchable abstracts of presentations at key conferences in endocrinology
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12th European Congress of Endocrinology

ea0022oc3.1 | Pituitary | ECE2010

Sgk1 effects on POMC transcription and ACTH release are opposite to those of glucocorticoids

Reiter Marie Helene , Vila Greisa , Baumgartner-Parzer Sabina M , Knosp Engelbert , Wagner Ludwig , Stalla Gunter K , Luger Anton

Glucocorticoid feed-back in pituitary corticotrophs represses POMC transcription and ACTH release. Serum and glucocorticoid-induced kinase 1 (Sgk1) has been identified as an immediate early target of glucocorticoids in many tissues, however its expression and function in corticotrophs are unknown.We show here that Sgk1 is present in the human pituitary gland at both mRNA and protein levels. Double-immunohistochemistry revealed that Sgk1 is expressed in d...

ea0022oc3.2 | Pituitary | ECE2010

Copeptin, an arginine vasopressin (AVP) marker, as a diagnostic aid in SIADH of cancer

Dixit Kashinath , Morgenthaler Nils , Brabant Georg

Copeptin is a stable AVP marker and stoichiometrically released with AVP. It closely reflects changes in water balance. Its stimulation in severe stress has recently has been suggested in various pathophysiological conditions including myocardial infarction and stroke. Paraneoplastic stimulation of AVP/copeptin is expected in patients with cancer leading to hyponatraemia due to SIADH.Here, we evaluated copeptin levels in 50 patients with hyponatraemia du...

ea0022oc3.3 | Pituitary | ECE2010

Trauma severity, but not hypopituitarism, affects cognitive function after traumatic brain injury: a multi-center study in The Netherlands

Kokshoorn Nieke , Smit Jan , Nieuwlaat Willy-Anne , Biermasz Nienke , Bisschop Peter , Veldman Ronald Groote , Roelfsema Ferdinand , Franken Anton , Wassenaar Moniek , Tiemensma Jitske , Romijn Johannes , Pereira Alberto

Background: Hypopituitarism after traumatic brain injury (TBI) is considered to be a prevalent condition, and may affect quality of life (QoL) and cognitive function. However, the prevalence of hypopituitarism differs considerably among reported studies due to differences in definitions, endocrine assessments of hypopituitarism, and confounding factors, like timing of evaluation and the severity of the trauma.Aim: To evaluate the prevalence of hypopituit...

ea0022oc3.4 | Pituitary | ECE2010

Influence of the d3-GH receptor polymorphism on the metabolic and biochemical phenotype of GH deficient adults at baseline and during short- and long-term rhGH replacement therapy

Giavoli Claudia , Ferrante Emanuele , Profka Eriselda , Olgiati Luca , Bergamaschi Silvia , Ronchi Cristina L , Verrua Elisa , Filopanti Marcello , Passeri Elena , Montefusco Laura , Lania Andrea G , Corbetta Sabrina , Arosio Maura , Ambrosi Bruno , Spada Anna , Peccoz Paolo Beck

A common polymorphic variant of the GH receptor (exon-3 deletion, d3GHR) has been linked with increased response to recombinant human GH (rhGH) in some, but not all, GH deficient (GHD) and non-GHD patients. Aim of this study was to investigate the impact of the GHR genotype on the phenotype of GHD adults and on the metabolic effect of short- and long-term rhGH therapy, with particular focus on glucose homeostasis (1 year: n=100 and 5 years: n=50). Effects of rhGH...

ea0022oc3.5 | Pituitary | ECE2010

Cortisol, but not ACTH/CRH, increases circulating ghrelin in man

Azzam Ibrahim , Limor Rona , Stern Naftali , Greenman Yona

We have recently explored the involvement of ghrelin in the eating response to stress in humans and found that ghrelin levels increased in parallel to cortisol after a standardized psychological stress. To further elucidate this interaction, we examined the ghrelin response to pharmacological manipulation of the HPA axis.Following approval from the local Ethical Committee, six lean, healthy male volunteers were examined on two occasions. Blood samples we...

ea0022oc3.6 | Pituitary | ECE2010

Young patients with sporadic macroadenomas as target population for AIP mutations screening

Tichomirowa Maria , Barlier Anne , Daly Adrian , Jaffrain-Rea Marie-Lise , Cozzi Renato , Yaneva Maria , Naves Luciana , Ronchi Christina , Sievers Caroline , Maiter Dominique , Montanana Carmen Fajardo , Zacharieva Sabine , Beckers Albert

Methods: We undertook an assessment of patients which were diagnosed with or had their first symptoms of pituitary tumor before the age of 30 and had tumor diameter more than 1 cm without familial history of pituitary adenomas. In patients that consented to genetic analysis, germline mutations in the AIP gene were sought.Results: The study population consisted of 164 patients (61 prolactinomas, 84 somatotropinomas, 16 non-secreting tumors, two pat...