Searchable abstracts of presentations at key conferences in endocrinology
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12th European Congress of Endocrinology

ea0022oc4.1 | Adrenals | ECE2010

Subtype differentiation in primary hyperaldosteronism: evaluation of alternative algorithms avoiding a controversial gold standard

Lang Katharina , Hahner Stefanie , Vonend O , Rump L C , Quninkler M , Diederich Sven , Maier Katharina , Beuschlein Felix , Bidlingmaier Martin , Endres S , Engelke C , Kickuth Ralph , Fassnacht Martin , Reincke Martin , Allolio Bruno

Context: Primary aldosteronism (PHA) is the most common cause of secondary hypertension. Distinguishing unilateral (UAH) from bilateral (BAH) and other causes of PHA is one of the greatest challenges in the diagnostic process. Adrenal venous sampling (AVS) is widely considered to be the gold standard for subtype differentiation.Methods: Technical and diagnostic outcome of AVS was analysed retrospectively in 59 patients with PHA who underwent AVS at the U...

ea0022oc4.2 | Adrenals | ECE2010

ESE Young Investigator Award

Spyroglou Ariadni , Wagner Sibylle , Bidlingmaier Martin , Bozoglu Tarik , Rathkolb Birgit , Schrewe Anja , de Angelis Martin Hrabe , Beuschlein Felix

In an attempt to define novel genetic loci involved in the pathophysiology of primary aldosteronism a mutagenesis screen after treatment with the alkylating agent N-ethyl-N-nitrosourea was established for the parameter aldosterone. One of the established mouse lines with hyperaldosteronism was phenotypically and genetically characterized. Affected animals showed an increased aldosterone to renin ratio (males unaffected, 1.1±0.1 pg/ml per ng per ml per hour v...

ea0022oc4.3 | Adrenals | ECE2010

Novel mutations in the glucocorticoid receptor gene: from familial bilateral adrenal hyperplasia to glucocorticoid receptor haploinsufficiency

Young Jacques , Trabado Severine , Bouligand Jerome , Amazit Larbi , Viengchareun Say , Guiochon-Mantel Anne , Delemer Brigitte , Lombes Marc

Glucocorticoid receptor (GR or NR3C1) is a ligand-dependent transcription factor that plays an essential role in differentiation, development, inflammatory responses and energy balance and is implicated in several human diseases. Eleven germinal GR mutations have been described so far, responsible for glucocorticoid resistance with variable clinical presentation.We report original heterozygous GR mutations in three independent patients, which have been i...

ea0022oc4.4 | Adrenals | ECE2010

Combined anticortisolic therapy by metyrapone, ketoconazole and mitotane: an alternative to adrenalectomy in severe Cushing’s syndrome

Kamenicky Peter , Droumaguet Celine , Baudin Eric , Salenave Sylvie , Trabado Severine , Cazabat Laure , Chanson Philippe , Young Jacques

Context: Mitotane due to its adrenolytic action is highly effective in long-term management of ACTH-dependent Cushing’s syndrome (CS). However, the slow onset of its anticortisolic effect makes its use problematic in severe CS, when very rapid therapeutic response is required. Association with metyrapone and ketoconazole, rapidly acting steroidogenesis inhibitors, could warrant CS control while waiting for the full efficiency of mitotane and thus avoid urgently performed ...

ea0022oc4.5 | Adrenals | ECE2010

Effects of mitotane on testicular adrenal rest tumors size, sperm count and adrenal steroidogenesis in patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency

Bachelot Anne , Salenave Sylvie , Renard Raphaelle , Rocher Laurence , Dulon Jerome , Coussieu Christiane , Brailly-Tabard Sylvie , Morel Yves , Touraine Philippe , Young Jacques

Testicular adrenal rest tumors (TART), described in patients with classic congenital adrenal hyperplasia (CAH) secondary to 21-hydroxylase deficiency, are responsible for Leydig cell failure and impaired spermatogenesis. These tumors, often unresponsive to intensified glucocorticoid therapy and surgical resection, may lead to infertility or even sterility. Here, we studied the effects of long term treatment with mitotane (Lysodren), a specific adrenolytic agent, on TART in 4 C...

ea0022oc4.6 | Adrenals | ECE2010

Serum cortisol predicts increased cardiovascular mortality in patients with acute coronary syndrome: the Ludwigshafen Risk and Cardiovascular Health (LURIC) Study

Tomaschitz Andreas , Pilz Stefan , Ritz Eberhard , Grammer Tanja , Drechsler Christiane , Boehm Bernhard , Maerz Winfried

Over the past several years, growing evidence suggested that serum cortisol is associated with increased cardiovascular (CVD) mortality in patients with chronic heart failure. The prognostic significance of serum cortisol concentration (SCC) in patients with acute coronary syndrome (ACS) however is unknown.In the prospective Ludwigshafen Risk and Cardiovascular Health (LURIC) study 3316 patients (median age: 63.5 (56.3–70.6) years; 30.2% women) were...