Searchable abstracts of presentations at key conferences in endocrinology
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12th European Congress of Endocrinology

Poster Presentations

Developmental endocrinology

ea0022p256 | Developmental endocrinology | ECE2010

Similar developmental patterns of ghrelin and glucagon immunoreactivity in the human pancreas

Vignjevic Sanja , Todorovic Vera , Micic Mileva , Drndarevic Neda , Budec Mirela , Mitrovic Olivera , Djikic Dragoslava , Djuricic Slavisa

Ghrelin is stored alongside glucagon in developing islet, although in a discrete cellular compartment, the pancreatic ε-cell. However, recent observations have shown a subpopulation of ghrelin/glucagon-double-positive cells in developing pancreas. The aim of the present study was to examine the developmental patterns of ghrelin- and glucagon-immunoreactive (ir) cells expression and possible co-localization of these hormones during human pancreas development. For this purp...

ea0022p257 | Developmental endocrinology | ECE2010

Mineralocorticoid pathway in newborns: evidence for a physiological renal aldosterone unresponsiveness

Martinerie Laetitia , Viengchareun Say , Boileau Pascal , Lombes Marc

Aldosterone is the main steroid hormone controlling sodium homeostasis in human. During the neonatal period, full term newborns and more specifically premature infants, are subjected to an impaired renal capacity to reabsorb sodium, responsible for sodium loss and failure to thrive which could be linked to a renal aldosterone unresponsiveness at birth. A clinical prospective study on 50 newborns and their mothers, revealed high aldosterone and renin levels in umbilical blood s...

ea0022p258 | Developmental endocrinology | ECE2010

De novo cholesterol synthesis in developing mouse embryo is required for embryonic survival

Jokela Heli , Rantakari Pia , Lamminen Tarja , Strauss Leena , Ola Roxana , Gylling Helena , Miettinen Tatu , Pakarinen Pirjo , Sainio Kirsi , Poutanen Matti

Hydroxysteroid (17-β) dehydrogenase enzymes (HSD17Bs) have an important role in sex steroid hormone metabolism. They are known to catalyze reactions between highly active 17β-hydroxy steroids and less active 17-keto steroids. In addition to sex steroid metabolism, it is becoming evident that HSD17Bs have functions in other pathways as well, e.g. lipid and bile acid metabolism. HSD17B type 7 enzyme is known to catalyze in vitro the activation of estrone (E1) to...

ea0022p259 | Developmental endocrinology | ECE2010

Partial loss of pancreas endocrine and exocrine cells of human ARX-null mutation: consideration of pancreas differentiation

Itoh Masayuki , Okazaki Shin , Miyata Rie , Inoue Takeshi , Akashi Takumi , Hayashi Masaharu , Goto Yuichi

Aristaless-related homeobox gene (ARX) mutation leads to several neurological disorders including X-linked lissencephaly with abnormal genitalia (XLAG), West syndrome and Partington syndrome, with XLAG being the most severe form. Although some of the brain pathology of XLAG has already been described, the crucial extra-brain symptoms are severe growth retardation, transient hyperglycemia and intractable diarrhea. Since ARX expresses in the islets of Langerhans du...

ea0022p260 | Developmental endocrinology | ECE2010

Quality of life and emotional state of adult patients with adult-onset, childhood-onset growth hormone deficiency and Turner syndrome

Lasaite Lina , Lasiene Danute , Lasas Liudvikas

Though results of scientific studies are rather controversial, it is known that adults with growth hormone deficiency (GHD) and Turner syndrome (TS) experience disturbances in psychological well-being and quality of life. Results of our previous studies confirm that quality of life and emotional state are worse in adult patients with adult-onset, childhood-onset GHD and TS than in age- and sex-matched controls.Aim: The aim of the study was to compare qua...

ea0022p261 | Developmental endocrinology | ECE2010

An inadequate maternal dietary protein level during pregnancy in pigs alters the expression of corticosteroid receptors and 11β-hydroxysteroid dehydrogenase isoforms in the placenta and fetal brain

Kanitz Ellen , Grabner Maria , Tuchscherer Margret , Brussow Klaus-Peter , Stabenow Bernd , Rehfeldt Charlotte , Metges Cornelia C , Otten Winfried

Imbalanced maternal nutrition during pregnancy can cause fetal growth retardation, metabolic changes and alterations of the hypothalamic–pituitary–adrenal (HPA) system in the offspring. Here, we investigated the effects of maternal low and high protein diets during pregnancy in pigs on materno-fetal HPA regulation and expression of glucocorticoid receptor (GR), mineralocorticoid receptor (MR), 11β-hydroxysteroid dehydrogenase 1 and 2 (11β-HSD1 and 11β-...

ea0022p262 | Developmental endocrinology | ECE2010

Lipid profile in type 2 diabetic patients in Kragujevac

Petrovic Jelena , Mladenovic Violeta , Djukic Aleksandar , Sipetic Sandra

Introduction: High total cholesterol (tChol), LDL and trygliceride (TAG) level is independent risk factor for cardiovascular disease. High prevalence of malignant atherogenic profile is alarming in type 2 diabetics (high triglyceride, low HDL). It is very often that dislipidemia is associated with diabetes and obesity, as well as hypertension.Aim: The aim of this study is to analyse lipid profile in patients with type 2 diabetes in Kragujevac depending o...

ea0022p263 | Developmental endocrinology | ECE2010

Gonadal structures in a fetus with complete androgen insensitivity syndrome and persistent Mullerian derivatives: comparison with the normal fetal development

Corbetta Sabrina , Marina Muzza , Laura Avagliano , Gaetano Bulfamante , Luigi Gaetti , Cristina Eller-Vainicher , Paolo Beck-Peccoz , Anna Spada

Androgens, by signaling through the androgen receptor (AR), mediate a wide range of male developmental processes. Complete androgen insensitivity syndrome (CAIS), a X-linked disorder caused by AR gene mutations, represents an in vivo model to study the role of androgens in sexual development. Here, we reported a case with CAIS at 20 weeks of gestational age harbouring a novel AR missense mutation (D767V), which was predicted to prevent androgen binding and...

ea0022p264 | Developmental endocrinology | ECE2010

Baseline characteristics and serum IGF1 levels in GH deficient (GHD) patients treated in the transition phase from adolescence into adulthood: data from the NordiNet International Outcome Study (IOS)

Weber Matthias M , Blankenstein Oliver , Jorgensen Jens Otto L , Pedersen Birgitte T , Rakov Viatcheslav , Christiansen Jens Sandahl

Background: Data from several clinical studies have demonstrated the benefit of GH treatment in relation to bone mineral density and body composition in young adults who received GH treatment in childhood due to GHD1–3. There are recommendations to use a higher GH dose in the transition phase compared to the GH dose required during adulthood to mimic the endogenous GH secretion4,5.Methods: Data from NordiNet IOS have been analy...

ea0022p265 | Developmental endocrinology | ECE2010

Maternal stress in early pregnancy: the reason of endocrine and behaviour disorders in female offspring

Sergienko Lorianna , Kartavtseva Oksana , Bondarenko Tatyana , Perets Olena , Cherevko Ganna

Objective: It is known that mother’s stress during prenatal period of gestation provokes the firm long-lasting disturbances of fetal functional systems. The consequences of stress within early pregnance (SEP) are still researched poorly.Aim: The aim of study was to evaluate hormonal and behaviour features in females – offspring of rats with SEP.Material and methods: For SEP creation the Wistar rat females were transferred...

ea0022p266 | Developmental endocrinology | ECE2010

Familial hypercalciuric hypercalcemia and severe neonatal hyperparathyroidism: a clinico-biochemical and molecular characterization in a Tunisian family

Monastiri Kamel , Bziouch Ahlem , Sfar Sana , Bouaziz Sofiane , Chioukh Fatma Zahra , Bizid Manel , Hamida Hayet Ben , Najjar Fadhel

Mutations that inactivate one allele of the gene encoding the calcium sensing receptor (CaSR) cause autosomal dominant familial hypocalciuric hypercalcemia (FHH), whereas homozygous mutations cause neonatal severe hyperparathyroidism (SNHPT).Objective: We describe the identification and biochemical characterization of a novel CASR gene mutation that caused SNHPT and FHH in a consanguineous kindred.Design: The study design involved ...