Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2010) 22 OC5.6

ECE2010 Oral Communications Reproduction & Thyroid (6 abstracts)

Universal screening detects twice more thyroid disorders in early pregnancy than targeted high-risk case finding

Jiri Horacek 1 , Sylvie Spitalnikova 2 , Blanka Dlabalova 1 , Eva Malirova 1 , Jaroslav Vizda 1 , Ioannis Svilias 1 , Catherine McGrath 1 & Jaroslav Maly 1

1Faculty of Medicine and University Hospital Hradec Kralove, Charles University in Prague, Hradec Kralove, Czech Republic; 2District Hospital Havlickuv Brod, Havlickuv Brod, Czech Republic.

Screening of thyroid disorders in pregnancy has been a matter of controversy. Recent recommendations favour targeted high-risk case finding though this approach may miss a significant number of those affected (Vaidya et al. JCEM 2007).

Among 398 non-selected women in the 10th week of pregnancy, thyrotropin (IRMA) >3.5 mIU/l was found in 10.3%, free thyroxine (RIA) <10 pmol/l in 2% and thyroperoxidase antibodies (RIA) >50 IU/ml in 8.3%; a total of 65 (16.3%) had at least one abnormality. After exclusion of those already treated for autoimmune thyroiditis, those identified were offered further endocrine examination.

Of these, 51 were seen in our endocrine clinic (incl. ultrasonography) and followed up; only 2 were left untreated, while levothyroxine was started in 49 (mostly 50 μg/day, range 50–100): in 42 for autoimmune thyroiditis and in 34 for hypothyroidism (in 27 for both).

They were also assessed according to 10 accepted high-risk criteria (Abalovich et al. JCEM 2007). Only 23 (45%) of positively screened women fulfilled at least one high-risk criterion: most commonly positive family history (31%), history of miscarriage or preterm delivery (14%), and positive personal history (8%).

In our cohort, therefore, over half (55%) of pregnant women with clear abnormalities suggestive of autoimmune thyroiditis and/or hypothyroidism, and indicated for treatment, would be missed if only those with high-risk criteria were examined.

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