ECE2010 Poster Presentations Developmental endocrinology (11 abstracts)
Though results of scientific studies are rather controversial, it is known that adults with growth hormone deficiency (GHD) and Turner syndrome (TS) experience disturbances in psychological well-being and quality of life. Results of our previous studies confirm that quality of life and emotional state are worse in adult patients with adult-onset, childhood-onset GHD and TS than in age- and sex-matched controls.
Aim: The aim of the study was to compare quality of life and emotional state of adult patients with adult-onset GHD, childhood-onset GHD and TS after discontinuation of GH treatment.
Subjects and methods: Eighteen patients with adult-onset GHD (age 27.8±5.3 years), 40 patients with childhood-onset GHD (age 24.0±6.9 years) and 18 patients with TS (age 21.5±4.1 years) after discontinuation of GH treatment. Quality of life was evaluated by adult growth hormone deficient quality of life questionnaire, emotional state by profile of mood states.
Results: Comparing quality of life in the researched groups of patients we did not find significant differences. Global score of emotional state differed significantly between patients with adult-onset GHD and TS (18.3±27.3 vs 36.3±38.2, P=0.0109) and between childhood-onset GHd and TS patients (12.4±0.4 vs 36.3±38.2, P=0.0072). No significant differences in emotional state were detected between adult-onset GHD patients and childhood-onset GHD patients.
In conclusion: Emotional state, but not quality of life is worse in adult patients with Turner syndrome than in adult-onset and childhood-onset growth hormone deficient patients after discontinuation of growth hormone treatment.