Hyperlipidemia is common among patients with ST-elevation myocardial infarction (STEMI) and is associated with high risk of mortality and morbidity. Hypertriglyceridemia and low HDL cholstereol are independent risk factor for cardiovascular disease.
Aim: The aim of this study is to analyse lipid profile in patients with STEMI with and without diabetes.
Material and methods: This study included all patients registered in Coronary Unit, Department of Cardiology, Clinical Center Kragujevac during 6 months. Patients lipid profile was measured on admission: total cholesterol (tChol), LDL, HDL and triglycerides (TAG).
Results: We studied 115 patients admitted consecutively with STEMI. There were 29 patients with previous diabetes. The majority of patients in the study were males (69.6%). The mean age of patients was 64.25±10.69 years. Anamnestic, only 13% STEMI patients had previous lipid disorder. According to National guideline clinical practise criteria: 53.3% had increased tChol level, 47.7% increased LDL 35.8% increased TAG i 63.8% decreased HDL cholesterol level. There is statisticaly significance in average tChol level (diabetics versus nondiabetics): (5.17±1.48 vs 4.69±1.66 mM, P=0.015), as well as LDL (3.27±1.23 vs 2.89±1.29 mM, P=0.017), but there is no significance in TAG (1.78±1.05 vs 1.77±1.06 mM, P>0.05) and HDL (1.09±0.35 vs 1.03±0.28 mM, P>0.05).
Conclusion: Patients with diabetes mellitus have higher levels of tChol and LDL cholesterol than patients without diabetes with STEMI. Our study showed not satisfied liporegulation in STEMI patients, especially in patients with diabetes.
Prague, Czech Republic
24 - 28 Apr 2010
European Society of Endocrinology