Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2010) 22 P331

ECE2010 Poster Presentations Diabetes (103 abstracts)

Transient insulin resistance during the laparoscopic versus open cholecystectomy

Dusan Micic 1 , Snezana Polovina 3 , Jelena Micic 2 , Zlatibor Loncar 1 , Dragan Micic 4 & Vladimir Djukic 1

1Emergency Center Serbia, Belgrade, Serbia; 2Clinic for Gynecology and Obstetrition, Clinical Center Serbia, Belgrade, Serbia; 3General Hospital Subotica, Subotica, Serbia; 4Clinic for Endocrinology, Diabetes and Metabolic Disease Clinical Center Serbia, Belgrade, Serbia.

Aim: The aim of our study was to investigate is surgical stress induce alterations in insulin sensitivity in the course of cholecystectomy performed in two differnt procedures: as a open surgery and as laparascopic operation.

Material and methods: The homeostasis assessment model (HOMA) was used to determine insulin sensitivity before and in the first, third and seventh day after the operation. Patients were divided int two groups: group A (open cholecystectomy; n=8; mean age 38.0±3.3; mean BMI 26.8938±1.5679) and group B (laparoscopic cholecystectomy; n=7; mean age 39.6±4.1; mean BMI 26.5867±1.8531).

Results: There were no diferences in HOMA index between group A and B before the operation (mean 2.4010±0.3230 vs 1.9798±0.6985; P>0.05) as well as for day 1 (2.5448±0.6044 vs 1.8370±0.5714; P>0.05) and day 7 (0.6494±0.4349 vs 0.7232±0.3898; P> 0.05). Group B had higher HOMA index at day 3 (7.5619±2.3360 vs 2.8016±0.7670; P<0.05).

Conclusion: There is transient increase in HOMA index after the operation in both procedures, compatible with deterioration in insulin sensitivity due to stress–response that is normalized a week after the operation.

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