Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2011) 25 P151

Diabetes, metabolism and cardiovascular

Serum erythropoietin levels in patients with acute myocardial infarction

Elham Islam, Iman Zaki, Mona Abdelsalam, Ahmed Abdelsalam, Samya Eltohamy & Ahmed Morsi

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Ain Shams University, Cairo, Egypt.


Background: Mortality and morbidity after acute myocardial infarction (AMI) remain high even when myocardial reperfusion is successful. Thus, additional approaches are warranted. Erythropoietin (EPO) was found to be a cytoprotective molecule that might represent a novel strategy to limit the infarct size.

Aim of the work: To investigate serum erythropoietin level and its relation to infarct size in Egyptian patients with AMI.

Methods: We studied 20 patients with AMI who underwent PCI within 12 h. Serum EPO levels were measured within 6 h and 7 days after the onset of AMI. Ten healthy subjects were controls.

Results: Serum EPO was higher among patients compared to controls. This increase was not related to haemoglobin and had a negative significant correlation with CK and wall motion score index while a positive significant correlation with ejection fraction. Patients with above median EPO level had lower CK and higher ejection fraction compared to those with below median EPO. Serum EPO significantly increased 7 days after the onset of MI and showed significant positive correlation with EPO within 6 h of the onset of MI.

Conclusion: High endogenous EPO level can predict a smaller infarct size in Egyptian patients with acute MI.

Key words: Erythropoietin, acute myocardial infarction, Egyptian

Abbreviations: AMI: Acute myocardial infarction, EPO: Erythropoietin, PCI: Percutaneous coronary intervention, CK: creatine phosphokinase

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