Searchable abstracts of presentations at key conferences in endocrinology
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13th European Congress of Endocrinology

Poster Presentations

Nuclear receptors

ea0026p359 | Nuclear receptors | ECE2011

Oleic and linoleic fatty acids reduce the SLC2A4 gene expression: the involvement of the NFkappaB and HIF-1a transcriptional factors

Poletto A C , Furuya D T , dos Santos R A , Anhe G F , Silva A D , Campello R S , Machado U F

Introduction: High circulating levels of some but not all unsaturated fatty acids (UFAs) can be related with reduced insulin sensitivity and glucose uptake in skeletal muscle. The real mechanisms by which UFAs impair the insulin sensitivity need to be clarified; nevertheless the UFA’s effects in the regulation of activity and/or expression of some transcriptional factors such as, nuclear factor κB (NFκB), hypoxia inducible factor-1a (HIF-1a), peroxisome prolifer...