Endocrine Abstracts (2011) 26 P159

Frequency of secondary GH deficit in patients with acromegaly undergone radiation or surgical treatment

Yu M Urmanova1,2 & M Yu Shakirova1,2

1Republican Specialized Scientific-Practical Medical Center of Endocrinology under the Ministry of Health of the Republic of Uzbekistan, Tashkent, Uzbekistan; 2Tashkent Medical Pediatric Institute, Tashkent, Uzbekistan.

Objective: To investigate frequency of secondary GH deficit (SGHD) in patients with acromegaly in the Republic of Uzbekistan (RUz).

Material and methods: There are 366 patients with acromegaly registered in RUz. We observed 15 patients with acromegaly with SGHD, among them 3 male and 12 female with middle age 51.6 years. All patients undergone following tests: pituitary hormones levels (GH, IGF1, ACTH, prolactin, TSH, FSH, LH, etc.), blood glucose, biochemical blood indicies, ECG, pituitary MRI/CT, densitomertry, visual fields, and others. Total hypophisectomy (THE) was performed to 4 patients, pituitary radiation therapy (PRT) – to 8 patients, THE+PRT – to 1 patient. Two patients undergone medical treatment.

Study results: We established that mean level of GH was significantly decreased (by 0.4±0.01 ng/ml). IGF1 level were also significantly decreased (97.5±7.3 ng/ml). All patients had deficit of 2 or 3 stimulating hormones, including SGHD.

We revealed post radiation hypopituitarism in 8 patients (53.3%), post operative hypopituitarism in 4 (26.6%), and combined hipopituitarism – in 1 (6.6%) patient. In 2 patients (13.3%) hipopituitarism has developed after medical treatment.

Conclusion: According to preliminary data, SGHD in patients with acromegaly may be the criterion of the process remission.

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