Introduction: It is well known fact that central lipid stores are related to glucose metabolism impairment. Standard anthropologic methods for measuring lipid stores centralisation are waist, waist to hip ratio and waist to height ratio. Still, often these markers fail to relate to difference in glucose metabolism between equally obese patients.
Method: We analysed relation between waist line radius and subcutaneous adipose tissue thickness, determent with ultrasound 3 cm left of umbilicus on waist line, as a measure of lipid stores centralisation. Participants were randomly sampled males, overweight and obese divided by fasting glucose level as normoglicemic, impaired fasting glucose or diabetes mellitus type 2. Standard anthropologic measures were taken and compared. We analysed homeostatic model for insulin resistance and insulin secretion. Results were statistically analysed with analysis of variance followed by Tacky T test and analysis of correlation.
Results: We found statistically significant difference between three equally obese groups when subcutaneous tissue thickness was added compared to standard markers of lipid stores centralisation. We also notified statistically strong correlation between such new marker and HOMA IS particularly in IFG group.
Conclusion: Relation between waist line radius and subcutaneous adipose tissue thickness provides significant correlation with HOMA IS in equally obese patients when standard anthropometric markers of lipid stores centralisation failed. This could prove to be useful tool for early discovering and monitoring of deleterious lipid store centralisation particularly in IFG group.
30 Apr - 04 May 2011
European Society of Endocrinology