Endocrine Abstracts

Driven by the rising global tide of obesity, insulin resistance is already at pandemic levels, and is intimately associated with major pathologies including type 2 diabetes, ovulatory dysfunction and hyperandrogenism, the spectrum of fatty liver disease, and disorders of growth including cancer. Yet despite intensive study of prevalent forms of the condition, major questions remain both about the nature of the genetic predisposition to insulin resistance, and the mechanisms li...

The number of people worldwide with diabetes is predicted to exceed 370 million by the year 2030. Over 90% of these will have type 2 diabetes with a twofold greater risk of heart disease and stroke than in the general population, and a reduction in life expectancy of five or more years.Type 2 diabetes is a condition of relative insulin deficiency. Insulin secretory responses to meal challenges are delayed and prolonged and, although fasting insulin level...