Searchable abstracts of presentations at key conferences in endocrinology
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Society for Endocrinology BES 2012

Poster Presentations

Cytokines and growth factors

ea0028p128 | Cytokines and growth factors | SFEBES2012

Muscle mass maintenance in the absence of follistatin-like 3 (FSTL3), an inhibitor of myostatin

Lessey Andrew , Donavon Douglas , Mukherjee Abir

Loss of muscle mass is associated with ageing and several degenerative pathological conditions which limit movement and critically impair quality of life. One key regulator of muscle mass is myostatin which inhibits muscle growth. In circulation, myostatin is bound to follistatin-like 3 (FSTL3) in an inactive complex. FSTL3 is a natural, soluble regulator of myostatin along with follistatin (FST) and myostatin propeptide. In the FSTL3 gene deleted mouse (FSTL3 KO), however, to...

ea0028p129 | Cytokines and growth factors | SFEBES2012

Circulating IGF-II concentration is associated with longitudinal increase in high density lipoprotein cholesterol in Type 2 diabetes

Narayanan Ram , Anderson Simon , Fu Bo , Hudson Julie , Oliver Rob , Siddals Kirk , Payton Anthony , Heald Adrian , Ollier William , Gibson John

Associations of Insulin-like growth factor-II with cardiovascular risk have been inadequately studied. We studied longitudinal associations of IGF-II with cardiovascular risk factors in people with type 2 diabetes. Subjects and methods: 462 type-2 diabetes patients aged 26 to 86 years from the Salford Diabetes cohort were analysed. Longitudinal clinical information was extracted (years 2002–2009) from an integrated database of primary care and hospital data. IGF-II was me...

ea0028p130 | Cytokines and growth factors | SFEBES2012

Polymorphisms of the IGFBP3 gene influence circulating IGF-II concentration in type 2 diabetes

Narayanan Ram , Siddals Kirk , Oliver Rob , Hudson Julie , Anderson Simon , Payton Anthony , Heald Adrian , Ollier William , Gibson John

Insulin-like growth factors have fundamental roles in metabolism and apoptosis. Circulating IGF-I and IGF-II are primarily sequestrated with IGFBP-3 in ternary complexes with the acid-labile subunit. We hypothesized that polymorphisms of the IGFBP3 gene may impact circulating IGF-II concentrations.Methods: 478 Caucasian patients were selected from the Salford Diabetes Cohort for analysis. Thirteen haplotype tagging single nucleotide polymorphisms (SNPs) ...

ea0028p131 | Cytokines and growth factors | SFEBES2012

Effects of long-term intermittent administration of GH on EGF signaling in liver

Diaz Maria , Miquet Johanna , Sotelo Ana , Turyn Daniel , Gonzalez Lorena

Growth hormone (GH) is involved in body growth and metabolism. This hormone is used for the treatment of various clinical conditions and is administrated subcutaneously once daily or 3 times a week. The chronic use of GH has side effects; among them, the increase in tumor incidence. GH activates pathways related with oncogenesis not only by the activation of its specific receptor, but also by transactivation and regulation of the expression of the epidermal growth factor recep...

ea0028p132 | Cytokines and growth factors | SFEBES2012

Effect of rimonabant and metformin on inflammatory cytokines in obese women with polycystic ovary syndrome

Konya Judit , Sathyapalan Thozhukat , Cho Li Wei , Coady Anne , Kilpatrick Eric , Atkin Stephen

Introduction: Polycystic ovary syndrome (PCOS) has shown to be associated with increased levels of pro-inflammatory cytokines. This study was undertaken to determine the changes of pro-inflammatory cytokines in patients with PCOS after rimonabant and/or metformin treatment.Methods: A 3 month randomised open labelled parallel study of rimonabant or metformin in 20 patients with PCOS with a body mass index >30 kg/m2 was undertaken. Subsequen...

ea0028p133 | Cytokines and growth factors | SFEBES2012

A role of follistatin-Like 3 (FSTL3) in cellular proliferation

Rehman Memoona , Mukherjee Abir

Follistatin like 3 (FSTL-3) is an endogenous inhibitor that binds and inhibits TGFβ family ligands such as activin, myostatin and GDF11. Activin plays crucial roles in development, cellular proliferation and apoptosis while myostatin is a known blocker of muscle growth. To identify physiological roles of FSTL3, FSTL3 gene deletion mice (FSTL3 KO) were generated which displayed altered glucose and lipid metabolism phenotypes. To address the role of FSTL3 in cellular biolog...