Searchable abstracts of presentations at key conferences in endocrinology
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Society for Endocrinology BES 2012

Poster Presentations

Growth and development

ea0028p134 | Growth and development | SFEBES2012

Growth hormone (gh)-transgenic mice exhibit gh-stat5 insensitivity associated with up-regulation of negative signaling modulators

Martinez Carolina , Piazza Veronica , Miquet Johanna , Ramirez Maria , Becu-Villalobos Damasia , Bartke Andrzej , Turyn Daniel , Sotelo Ana

JAK2/STAT5 is the principal growth hormone (GH) signaling pathway related to body growth. It is positively regulated by glucocorticoid receptor (GR) and hepatocyte nuclear factor 1 (HNF-1) and downregulated by activation of tyrosine-phosphatases SHP-1,-2 and PTP-1B, and by GH-induction of suppressors of cytokine signaling (CIS/SOCS) that block GHR or JAK2, and promote internalization/degradation of signaling complexes. This pathway is desensitized in liver of adult transgenic ...

ea0028p135 | Growth and development | SFEBES2012

Loss of annexin 1 in mice leads to reduced proliferation in the neurogenic subventricular zone

Stock Lisanne , Szele Francis , Morris John , Christian Helen

Annexin 1 (ANXA1) is a glucocorticoid-regulated, calcium and phospholipid-binding protein well recognized as an important signalling intermediate in both peripheral systems and the brain. Online adult mouse brain gene libraries have reported ANXA1 mRNA expression in the subventricular zone (SVZ) lining the lateral ventricles. The SVZ is one of the two largest neurogenic areas of the brain and as ANXA1 plays a known role in cell differentiation and proliferation, we have invest...

ea0028p136 | Growth and development | SFEBES2012

Maturational effects of glucocorticoids on fetal cardiomyocytes are direct and mediated by glucocorticoid receptor

Rog-Zielinska Eva , Kenyon Chris , Holmes Megan , Chapman Karen

In addition to their essential role in fetal lung development, glucocorticoids promote late-gestation maturation of the fetal heart as shown by severe functional impairment, structural disorganisation and transcriptome immaturity in fetal hearts of glucocorticoid receptor-deficient (GR-/-) mice. Here we use primary fetal mouse cardiomyocytes (E16-E17.5) to investigate whether these effects of glucocorticoids result from direct actions of GR and whether they are independent of ...

ea0028p137 | Growth and development | SFEBES2012

Under-replacement with growth hormone during transition

Staniforth Joy , Thankamony Ajay , Halsall David , Simpson Helen

Introduction: The benefits of growth hormone (rGH) replacement during the transition from childhood to adulthood are well established. In adulthood rGH dose is optimized by titrating to serum IGF-I concentration. The use of non-specific IGF-I reference ranges may result in erroneous assessment of IGF-I concentration and inappropriate rGH dosing.Methods: IGF-I methods and reference ranges across 9 UK centres were reviewed. Immulite IGF-1 results for a 12 ...

ea0028p138 | Growth and development | SFEBES2012

More information, please! Results of a survey on men with Klinefelter’s syndrome and their satisfaction with information and support from healthcare professionals

Jackson Sue , Morris Marianne , Ruddle Georgina

Introduction: Klinefelter’s Syndrome (KS) is a genetic condition affecting men with the potential to severely reduce testosterone levels and affect physical appearance. Being a syndrome there are a variety of different symptoms which individuals may experience to a great or lesser extent. With no screening programme in place, KS may not be detected until puberty, or until men have problems starting a family. As a result, many different healthcare professionals (HCPs) are ...

ea0028p139 | Growth and development | SFEBES2012

Comparison of injection dose force, accuracy and precision between two growth hormone disposable injection devices

Kappelgaard Anne-Marie , Hansen Marianne Rye , Hansen Niels Aage

Background: A reduced injection force potentially makes it easier for patients to administer their injected medication.Objective and Hypotheses: This report compares dose force, dose accuracy and dose precision of two growth hormone injection devices: Norditropin® NordiFlex® (NF) (Novo Nordisk A/S, Denmark) and Genotropin® GoQuick® (GQ) (Pfizer Inc, NY, USA).Methods: M...