Endocrine Abstracts

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Tumor-induced osteomalacia (TIO) is a paraneoplastic syndrome characterized by hypophosphatemia associated with renal phosphate wasting and low to low normal serum level of 1,25-dihydroxyvitamin D (1,25(OH)2D). FGF23 was identified as a causative factor for TIO which inhibits proximal tubular phosphate reabsorption and decreases serum 1,25(OH)2D by modifying the expression levels of vitamin D-metabolizing enzymes. This disease is cured by complete resection of responsible tumo...

FGF23 secretion is increased in response to 1,25(OH)2 vitaminD3 (1,25D) and an oral phosphorus (P) load. Patients with chronic kidney disease (CKD) are unable to excrete their dietary P which contributes to an increased secretion of the two major phosphaturic hormones, PTH and FGF23. The increased FGF23 would normally bind to its receptor, klotho-FGFR1 in the renal tubules to increase P clearance and decrease the synthesis of 1,25D. Increased FGF23, P and PTH levels are all as...