Endocrine Abstracts

Nutrition is a crucial regulatory component of the reproductive physiology. Conditions of negative energy balance or low energy store often causes a disruption of the neuroendocrine reproductive axis and arrest of sexual maturation. On the other hand, excess energy, as observed in obesity, also negatively impacts the reproductive physiology. For example, high adiposity may induce or aggravate polycystic ovarian syndrome, ovulatory dysfunction and hypothalamic amenorrhea. In ob...

The incidence of obesity has dramatically increased, not only in industrialized societies but also in developing countries. Since male fertility shows a parallel decrease, obesity should be considered as possible etiology of male subfertility.Studies exploring this possible association report that obesity may affect fertility by different mechanisms that include: abnormal reproductive hormonal milieu, increased release of adipokines and adipose-derived h...

With an increasing prevalence of overweight and obesity, there is abundant evidence linking these conditions with sub- and infertility in women. The evidence in men is less well developed but is emerging gradually. Even when fertility is achieved in women, there are many conditions of pregnancy that are increased including diabetes mellitus, hypertension, congenital abnormalities and peripartum problems. Children born also have an increased long-term problem of obesity and ass...