Searchable abstracts of presentations at key conferences in endocrinology
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15th International & 14th European Congress of Endocrinology


Pituitary tumorigenesis

ea0029s22.1 | Pituitary tumorigenesis | ICEECE2012

Molecular mechanisms: the genes involved in pituitary tumorigenesis

Melmed S.

Pituiatry tumors account for about 15% of all intracranial neoplasms. They arise from pituitary cell types due to both cell cycle trophic dysruptions leading to adenomatous growth, as well as a coupling of specific hormone gene over-expression. Thus, both tumor growth characteristics, as well as hormonal excess are the hallmarks of these invariably benign tumors. They may lead to both central compressive features due to mass expansion or invasion, as well as to specific clinic...

ea0029s22.2 | Pituitary tumorigenesis | ICEECE2012

Tracing back a Gene’s influence

Korbonits M.

In the late 1700s, a 22 y patient suffering from pituitary gigantism died and his skeleton was deposited in a medical museum. A contemporary etching showed him standing alongside a set of giant twin brothers who were believed to be his cousins. The existence of such a rare disorder within closely related family members indicates to modern science a genetic dimension to their disease. In 1909 Cushing opened the skull and he found a greatly enlarged pituitary fossa. We identifie...

ea0029s22.3 | Pituitary tumorigenesis | ICEECE2012

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