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Endocrine Abstracts (2012) 29 P1036

ICEECE2012 Poster Presentations Male Reproduction (63 abstracts)

Severe depressive symptoms and cardiovascular risk in subjects with erectile dysfunction

A. Fisher 1 , E. Bandini 1, , G. Corona 1 , V. Ricca 2 , M. Monami 3 , V. Boddi 1 , D. Balzi 4 , C. Melani 4 , G. Forti 1 , E. Mannucci 4 & M. Maggi 1

1Sexual Medicine and Andrology Unit, Florence, Italy; 2Psychiatry Unit, Florence, Italy; 3Diabetes Section, Geriatric Unit, Florence, Italy; 4Epidemiological Unit, Florence, Italy.

Introduction: Although penile blood flow (PBF) has been recommended as an additional diagnostic test in identifying erectile dysfunction (ED) patients at risk for latent cardiovascular disease, no study has ever assessed the possible association of PBF and the relational component of sexual function with incident major cardiovascular events (MACE).

Aim: The aim of this study is to investigate whether severity of ED, PBF and other factors related to a couple`s relationship predict incident MACE.

Methods: A consecutive series of 1687 patients was studied. Different clinical, biochemical and instrumental (penile flow at color doppler ultrasound: PCDU) parameters were evaluated.

Main outcomes measures: Information on MACE was obtained through the City of Florence Registry Office.

Results: During a mean follow-up of 4.3±2.6 years, 139 MACE, of which were fatal, were observed. Cox regression analysis, after adjustment for age and Chronic Disease Score, showed that severe ED predicted MACE (hazard ratio (HR) 1.75; 95% confidence interval (CI) 1.10–2.78; P<0.05). In addition, lower PBF, evaluated both in flaccid (before) and dynamic (after PGE1 stimulation) conditions, was associated with an increased risk of MACE (HR =2.67 (1.42–5.04) and 1.57 (1.01–2.47) respectively for flaccid (<13 cm/s) and dynamic (<25 mc/s) peak systolic velocity; both P<0.05).

Reported high sexual interest in the partner and low sexual interest in the patient proved to have a protective effect against MACE.

Conclusions: the investigation of male sexuality, and in particular penile blood flow and sexual desire, could provide insights not only into present cardiovascular status but also into prospective risk.

Declaration of interest: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project.

Funding: This research did not receive any specific grant from any funding agency in the public, commercial or not-for-profit sector.

Volume 29

15th International & 14th European Congress of Endocrinology

European Society of Endocrinology 

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