ICEECE2012 Poster Presentations Male Reproduction (63 abstracts)
The mitochondrial citrate carrier regulates insulin secretion by human male gamete
A. Cappello , C. Guido , A. Santoro , M. Santoro , F. De Amicis , D. Montanaro , S. Marsico , V. Dolce & S. Aquila
University of Calabria, Cosenza, Italy.
Sperm energy management is poorly studied and understood. The present study provides biochemical and morphological evidence that ejaculated human sperm express the mitochondrial citrate carrier (CIC) which is restricted to the midpiece. CIC inhibition by the specific substrate analogue 1,2,3-benzenetricarboxylate (BTA) reduced cholesterol efflux, proteins tyrosine phosphorylation, P-AKT, P-P60src addressing to its functional role in sperm acquisition of fertilizing ability. Worthy, CIC inhibition reduced sperm insulin secretion, glucose-stimulated insulin secretion (GSIS) and glucose-6-phosphate dehydrogenase (G6PDH) activity, supporting its role in the regulation on insulin secretion. In this study, we discovered a novel sperm factor involved in the regulation of metabolism and acquisition of sperm fertilizing ability. It may be taken into account as molecular target in the therapies designed for male infertility disorders.
Declaration of interest: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project.
Funding: This research did not receive any specific grant from any funding agency in the public, commercial or not-for-profit sector.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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