Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2012) 29 P1066

Hospital Universitario Reina Sofía, Córdoba, Spain.


Objetive: Evaluate the efficacy of subcutaneous HCG with or without FSH in male infertility associated to hypogonadotropic hypogonadism (HH).

Patients and methods: Descriptive study of patients with HH treated with HCG s.c. with or without FSH, for fertility objective (2004–2011). The Treatment was initiated with HCG 500 UI/72 h s.c., periodic monitoring of testosterone and semen analysis was realized, adjusting doses up to 2500 UI/72 h. If no answer obtained after 1 year, combined treatment with FSH s.c. was started. Analyzed data: cause of HH, age, testosterone levels, semen, dose of HCG and FSH treatment. The result has been assessed to the achievement of pregnancy.

Results: Ten patients. 30.6±2.9 years old. Cause of HH: 50% idiopathic, 20% nonfunctioning pituitary adenoma, 10% prolactinoma, 10% acromegaly and 10% craniopharyngioma. Fertility 60%, 22.6±13.5 months treatment time. Only one patient discontinued treatment without success. No presence of side effects. Subgroup result:

Conclusions: Subcutaneous gonadotropin therapy is effective in infertility HH. Treatment with subcuataneous HCG alone is successful. No presence of side effects.

Declaration of interest: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project.

Funding: This research did not receive any specific grant from any funding agency in the public, commercial or not-for-profit sector.

Table 1 Subgroup results.
Less than 24 months (n=6)More than 24 months (n=4)
Patients (%)6040
Doses HCG (UI/72 h)1250±612.42125±750
FSH (%)3050
Testosterone (mcg/l)7.6±3.97.3±5.5
Time (months)13.2±7.536.7±3.4
Fertility (%)5075

Volume 29

15th International & 14th European Congress of Endocrinology

European Society of Endocrinology 

Browse other volumes

Article tools

My recent searches

No recent searches.