Endocrine Abstracts

Introduction: It is known that diabetes mellitus and its complex yet insufficiently known mechanisms affect bone strength and increases the fracture risk.

Objective: The aim of this study was to assess bone mass measured by lumbar spine and hip DXA, in patients suffering from diabetes mellitus according to sex and type of diabetes.

Material and methods: It was a prospective study. Included 150 diabetic patients of both sexes.

Results: In type 1 diabetes mellitus were 11 men, age 40.82±8.99 years, BMI 23.24±3.45 kg/m² and duration of diabetes mellitus 12.67±9.30 years. Also in type 1 diabetes mellitus were 20 women of age 42.81±11.77 years, BMI 24.33±2.99 kg/m² and duration of diabetes mellitus 23.65±11.57 years. In type 2 diabetes mellitus were 21 male age 58.57±11.12 years, BMI 29.51±7.67 kg/m² and duration of diabetes 9.57±7.21 years. Also in type 2 diabetes mellitus were 98 women, age 64.15±9.28 years, BMI 29.99±5.57 kg/m² and duration of diabetes mellitus 11.99±8.34 years. In diabetes mellitus type 1 in four men has osteopenia (57%) and in seven (43%) normal results. The value of L1-L4 BMD was 1.233±0.147 g/cm², total femur 0.998±0.149 g/cm² and femoral neck 0.982±0.165 g/cm². In women with type 1 diabetes mellitus was 6 (30%) with normal findings, 10 (50%) with osteopenia and 4 (20%) with osteoporosis. The value of L1–L4 BMD was 1.088±0.151 g/cm², total femur 0.878±0.132 g/cm² and femoral neck 0.864±0.138 g/cm². In men with type 2 diabetes mellitus normal finding was identified in 12 (57.1%), osteopenia in 8 (38.1%) and in 1 (4.8%) osteoporosis. The value of L1–L4 BMD was 1.191±0.163 g/cm², total hip 1.064±0.179 g/cm² and femoral neck 0.895±0.457 g/cm². In women with type 2 diabetes mellitus had normal findings 27 (27.6%), osteopenia 41 (41.8%) and osteoporosis 30 (30.6%). The value of L1–L4 BMD was 1.071±0.201 g/cm², total femur 0.914±0.162 g/cm² and femoral neck 0.858±0.153 g/cm².

Conclusion: Osteopenia predominates in all patients with type 1 diabetes and in women with type 2 diabetes. It was determined a lower BMD at the femur, primarily in the neck of the femur, in all patients.

Declaration of interest: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project.

Funding: This research did not receive any specific grant from any funding agency in the public, commercial or not-for-profit sector.