Endocrine Abstracts

Aim: In this study, our aim was to investigate frequency of impaired glucose tolerance (IGT), undiagnosed diabetes mellitus (DM) and presence of insulin resistance by HOMA.

Material and method: Fifty-five primary hyperparathyroid patients without known glucose tolerance were included in this study. The control group was with similar BMI, normocalcemic, without known glucose tolerance. Seventy-five gram oral glucose tolerans test was performed to PHP patients and control group. Insulin resistance was calculated by HOMA-IR.

Results: Mean body mass index (BMI) was 29.16±4.92 kg/m² in PHP group, 29.54±4.38 kg/m² in control group (P=0.676). Serum Ca level was 10.46±0.81 mg/dl in patient group, 9.26±0.39 mg/dl in control group (P=0.000). While IGT was detected in 6 PHP patients (%11.3), there is no IGT in control group (P=0.013). Diabetes mellitus (DM) didn’t detect in OGTT in PHP patients. HOMA-IR was 1.51±0.89 in PHP group, 1.36±0.92 in control group (P=0.458). Second hour glucose OGTT value was significantly higher than control group (respectively, 99.28±30.86 mg/dl, 81.05±24.89 mg/dl, P=0.001). Second hour insulin OGTT value was significantly higher than control group (respectively, 22.84±17.92 μIU/ml, 14.94±14.10 μIU/ml, P=0.02). In both groups there were positive correlation between Ca levels and fasting plasma glucose, OGTT second hour glucose, OGTT second hour insulin (respectively, P=0.011, r=0.241; P=0.000, r=0.400; P=0.004, r=0.296).

Conclusions: Frequency of IGT is increased in PHP patients. Increased levels of serum Ca affects the glucose metabolism and leads to glucose intolerance.

Declaration of interest: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project.

Funding: This research did not receive any specific grant from any funding agency in the public, commercial or not-for-profit sector.