Endocrine Abstracts

Background and Aim: Clinical and experimental studies demonstrated that total insulin-like growth factor 1 (IGF-1) levels are reduced in the patients with poorly controlled diabetes. The aim of the present study was to investigate the levels of IGF-1 in patients with acute metabolic acidosis.

Materials and Methods: 17 patients with thype 1 diabetes and moderate or severe metabolic acidosis were recruited for this study. Serum levels of IGF-1 were determined by radioimmunoassay. Results were compared with 12 diabetic controls without metabolic acidosis.

Results. The subjects of study group: 8 women (47.05%) and 9 men (52.94%) were 26 to 38 years (30.20±3.22 years). 13 patients (76.47%) exhibit moderate metabolic acidosis (according to American Diabetes Association, moderate acidosis is characterized by pH 7.00–7.25, bicarbonate 10–15 mmol/l), and 4 patients (23.52%) severe ketoacidosis (according American Diabetes Association severe acidosis is characterized by pH below 7.00, bicarbonate below 10 mmol/l) Diabetic ketoacidosis occurs due to intercurrent illness and poor compliance with insulin therapy. The levels of IGF-1 were significantly decreased in patients with thype 1 diabetes with metabolic acidosis compared to those without metabolic acidosis (122 ng/dl vs 286 ng/dl, p<0.005). The normal IGF1range for age 25–39 years 114 to 492 ng/dl

Conclusion. In this study we found significant differences for the IGF-1 levels between patients with diabetic ketoacidosis and patients with thype 1 diabetes without ketoacidosis. Our results are consistent with several studies that have reported that in diabetic ketoacidosis IGF-1 is impaired.

metabolic acidosis, insulin-like growth factor 1 levels, thype 1 diabetes

Declaration of interest: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project.

Funding: This research did not receive any specific grant from any funding agency in the public, commercial or not-for-profit sector.