ICEECE2012 Poster Presentations Growth hormone IGF axis - basic (23 abstracts)
Health related quality of life and psychological functioning of short statured German children and adolescents: findings form the quality of life in short stature youth study
J. Quitmann 1 , J. Behncke 1 , J. Chaplin 6 , A. Pleil 2 , M. Herdman 4 , A. Rohenkohl 1 , E. Mimoun 7 , H. Wollmann 3 , M. Bullinger 5 & M. Power 1
1University Medical Center Hamburg-Eppendorf, Hamburg, Germany; 2UniverPfizer Specialty Care Business Unitsity Medical Center Hamburg-Eppendorf, San Diego, California, USA; 3Pfizer GmbH, Tübingen, Germany; 4Insight Consulting & Research S.L., Barcelona, Spain; 5The University of Edinburgh, Edinburgh, UK; 6University of Gothenburg, Gothenburg, Sweden; 7Hopital Des Enfants, Toulouse, France.
Background: About 3% of all children are short statured. Clinically GH deficiency (GHD) or idiopathic short stature (ISS) is frequently diagnosed. GH (GH−) treatment, which is primarily indicated for GHD patients, is provided not only to increase height, but also to improve psychological functioning and raise health related quality of life. The present study examines these psychosocial outcomes in young German patients and their parents, and analyzes differences according to clinical and sociodemographic sample characteristics.
Methods: As part of the international QOLISSY study 143 German patients between 4 and 18 years and their parents filled out the strengths and difficulties questionnaire (SDQ) assessing psychological functioning and a generic health-related quality of life questionnaire (KIDSCREEN 52). Patient self-report and parent reported data were compared with representative German norm data.
Results: In the KIDSCREEN 52, short statured children and adolescents reported a significantly lower total health related quality of life (HrQOL) score compared to a representative German sample (P<0.01), and especially regarding their psychological wellbeing (P=0.04). No differences within the patient sample were found regarding gender, age, diagnosis and treatment status or actual height. Height also had no significant impact on psychological problems or psychosomatic complaints. Analysing the SDQ data no significant differences (P=0.83) were found between this sample and a representive sample.
Parent and patient perspectives, however, differed: parents rated the HrQOL of their children significantly higher than their children did (P<0.01), and patients self-report of psychological difficulties was higher than the report from the parental perspective (P<0.01).
Conclusion: This cross-sectional study found impairments in self-reported psychological functioning and HRQOL of short statured children as compared to norms, but no differences between patient subgroups. Differences between patient and parent perspectives, however, suggest conflicting viewpoints and specific problems for children which need to be addressed in respective psychosocial interventions.
Declaration of interest: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project.
Funding: This work was supported, however funding details unavailable.
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Endocrine Abstracts
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