Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2012) 30 OC4.3

BSPED2012 Oral Communications Oral Communications 4 (5 abstracts)

White UK children are older, more obese and more insulin resistant than non-White UK children at diagnosis of type 2 diabetes: baseline results of the UK national type 2 diabetes cohort

Zoe Gray 1 , Emma Ilsley 2 , Catherine Cotter 1 , Lydiah Makusha 1 , Anna Ford 3 , Kelly Turner 4 , James Heywood 5 , Anthony Barnett 2 , David Dunger 5 , Julian Hamilton-Shield 6 , Jeremy Wales 7 & Timothy Barrett 2

1Birmingham Children’s Hospital NHS Foundation Trust, Birmingham, UK; 2University of Birmingham, Birmingham, UK; 3Sheffield Children’s Hospital, Sheffield, UK; 4Royal London Hospital, London, UK; 5University of Cambridge, Cambridge, UK; 6University of Bristol, Bristol, UK; 7University of Sheffield, Sheffield, UK.

Objectives: Type 2 diabetes (T2DM) has increased in UK children since the first reports in 2000; however it is poorly characterised and management practice varies across the UK. We aimed to describe the characteristics of the first 125 children recruited to the UK national study.

Methods: We recruited children with: paediatrician diagnosis of T2DM; body mass index (BMI) above 85th centile for age and sex; other diagnoses such as monogenic diabetes excluded. Clinical data was collected into a national database. Blood was taken for DNA and diabetes auto-antibody status.

Results: We were notified of 256 presumed affected children and have recruited 145 so far. Exclusions: auto-antibody positive (13); secondary diabetes (7). After exclusions M:F ratio was 1:2.6; white UK origin (49%); South Asian (SA) origin (29%); African-Caribbean (A-C) (12%); other (10%). Mean age at diagnosis was 13.2 yrs and mean duration of diabetes 3.0 years. White children were older at diagnosis (mean 13.4 years vs SA (13.2 years), A-C (12yrs; white vs A-C P<0.04)); fatter at diagnosis (BMI–SDS white (3.2), SA (2.8), A-C (2.7); white vs S-A P<0.01). White children trended towards lower HbA1c (white 9.2%, SA 8.7%, A-C 10.5%); and higher fasting C-peptide (white 1594 pmol/l; SA 1229 pmol/l; A-C 935 pmol/l). 19% of A-C children had resting heart rate more than 2 SD’s above the mean, vs 8% in SA and 7% in white children. There were no significant differences in resting blood pressure between groups.

Conclusion: White UK children are older at diagnosis than non-White children, more obese, and probably more insulin resistant. African-Caribbean children have poorer metabolic control and signs of cardiovascular dysfunction compared to white and SA children. A significant proportion of children still have raised C-peptide levels soon after diagnosis of diabetes, raising the possibility of therapeutic intervention to preserve pancreatic beta cell function early in the disease process.

Volume 30

40th Meeting of the British Society for Paediatric Endocrinology and Diabetes

British Society for Paediatric Endocrinology and Diabetes 

Browse other volumes

Article tools

My recent searches

No recent searches.