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Endocrine Abstracts (2013) 31 P219 | DOI: 10.1530/endoabs.31.P219

Division of Metabolic and Vascular Health, University of Warwick, Coventry, UK.

Background/aim: The global obesity epidemic has promoted a search for novel solutions. One approach is through modification of eating-related behaviours. Our aim was to explore the effects of meal duration on energy expenditure, appetite and excursions of molecules associated with insulin sensitivity in the post-prandial phase.

Methods: Normoglycaemic, pre-menopausal, Caucasian obese women (n=8) were recruited from the Obesity clinic at Warwickshire Institute for the Study of Diabetes, Endocrinology and Metabolism (WISDEM, UHCW). Whole-body indirect calorimetry (6-h) was performed on each subject on two separate occasions, with standard lunch (763 kcal: 50% carbohydrate) ingested over 10- vs 40-min. Blood tests were taken at baseline (fasting) and at 30, 60, 90, 120, 180 and 240 min following mid-meal, and analysed for glucose, insulin and non-esterified fatty acids (NEFA). Number/composition of calories ingested during a standard buffet meal (240-min) was assessed. Paired-sample t-tests were used. P<0.05 was considered statistically significant.

Results: Overall, following the 10- vs 40-min meals, there were significant differences in post-prandial plasma glucose (mean 6.4 mmol/l (S.D. 1.4) vs 6.0 mmol/l (S.D. 1.3) respectively, P=0.01) and serum NEFA concentrations (mean 243 μmol/l (S.D. 224) vs 191 μmol/l (S.D. 171) respectively, P=0.005). There was a trend towards greater post-prandial insulin resistance following the 10- vs 40-min meals (HOMA2 IR 2.1 (S.D. 2.0) vs 1.9 (S.D. 1.7) respectively, P=NS). Post-prandial energy expenditures were equivalent between the two meal durations (range 80–120 kcal/h). Regarding buffet selection (t=240-min), total number/composition of calories ingested were equivalent between the meal durations.

Conclusion: Our novel data highlight that meal duration impacts on systemic glucose and NEFA in obese women. Eating a meal more quickly increases overall exposure to glucose and NEFA, with a trend towards increased insulin resistance during the post-prandial phase; whilst no impact was noted on energy expenditure or appetite. Longer meal durations may therefore facilitate better maintenance of metabolic health.

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