Searchable abstracts of presentations at key conferences in endocrinology
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15th European Congress of Endocrinology

Oral Communications

Bone & Calcium

ea0032oc2.1 | Bone & Calcium | ECE2013

Bone mass accrual following supplementation of vitamin D alone versus vitamin D+ calcium in underprivileged Indian premenarcheal girls

Kota Sunil Kumar , Meher Lalit Kumar , Jammula Sruti , Modi Kirtikumar D

Objective: To determine effectiveness of supplementing vitamin D alone vs vitamin D+ calcium on bone mass accrual in underprivileged Indian premenarcheal girls.Methods: A double blind, matched pair, cluster randomization study was carried out in 200 premenarcheal girls (8–12 years) from three public schools. The participants were randomized into two clusters and were allocated to receive either vitamin D (Group A): 30 000 IU oral cholecalciferol eve...

ea0032oc2.2 | Bone & Calcium | ECE2013

Influence of vitamin D and calcium on reproductive hormones: a study in a VDR-ablated male mouse model and 300 healthy men

Jensen Martin Blomberg , Lieben Liesbet , Nielsen John E , Willems Ariane , Juul Anders , Jorgensen Niels , Toppari Jorma , Carmeliet Geert , Rajpert-De Meyts Ewa

Introduction: Vitamin D (VD) is metabolized locally in the testis, and ablation of the VD receptor (Vdr−/−) in mice has proven a valid model for hereditary VD resistant rickets. However, only one of three published Vdr−/− strains presented with male infertility. Here, we investigated reproductive hormones, gene expression and the testicular histological phenotype of male Vdr−/−mice,...

ea0032oc2.3 | Bone & Calcium | ECE2013

Screening for GNAS genetic and epigenetic alterations in progressive osseous heteroplasia: first Italian series

Elli Francesca Marta , Barbieri Annamaria , Bordogna Paolo , Giardino Elena , Ferrante Emanuele , Beck-Peccoz Paolo , Spada Anna , Mantovani Giovanna

Progressive osseous heteroplasia (POH) is a rare autosomal dominant disorder of mesenchymal differentiation characterized by progressive heterotopic ossification (HO) of dermis, skeletal muscle and deep connective tissues. Initially HO occurs during infancy as osteoma cutis, then extends progressively into deep connective tissues during childhood. Most cases of POH are caused by paternally inherited mutations of GNAS gene. Maternal mutations as well as epigentic defec...

ea0032oc2.4 | Bone & Calcium | ECE2013

Natural course of changes in bone mineral density after orthotopic liver transplantation: up to 5 years follow-up in a single centre

Krol Charlotte , Dekkers Olaf , Meiland Desi , van Hoek Bart , Hamdy Neveen

Introduction: Low energy trauma fractures are prevalent in end-stage liver disease and after orthotopic liver transplantation (OLT). However, data on bone mineral density (BMD) are scarce in these patients. In this study, we evaluated the natural course of changes in BMD after successful OLT.Study design: All recipients of a successful OLT between 2000 and 2011 from the Leiden University Medical Centre, in whom BMD data were available, were included. Pat...

ea0032oc2.5 | Bone & Calcium | ECE2013

Genetic analysis of CDKN1B gene in familial primary hyperparathyroidism

Pardi Elena , Borsari Simona , Saponaro Federica , Banti Chiara , Pellegata Natalia , Lee Misu , Vignali Edda , Meola Antonella , Mastinu Marco , Mariotti Stefano , Marcocci Claudio , Cetani Filomena

Primary hyperparathyroidism (PHPT) is usually a sporadic disorder, but in <10% of cases occurs as part of hereditary syndromes, including multiple endocrine neoplasia types 1 and 2A (MEN1 and MEN2A), hyperparathyroidism-jaw tumor syndrome (HPT-JT) and familial isolated hyperparathyroidism (FIHP).MEN 1 is an autosomal dominant disorder characterized by tumours in multiple endocrine glands, most commonly parathyroid, enteropancreatic and anterior pitui...

ea0032oc2.6 | Bone &amp; Calcium | ECE2013

Hypomineralized teeth as biomarkers of exposure to endocrine disruptors

Jedeon Katia , Molla De La Dure Muriel , Brookes Steven , Marciano Clemence , Canivenc-Lavier Marie-Chantal , Berdal Ariane , Babajko Sylvie

MIH for Molar Incisor Hypomineralization is a recently described pathology affecting around 18% of six year old children. Although a number of putative factors have been hypothesized, etiology of MIH remains unknown. The parallel increase of exposure to endocrine disruptors (EDs) and the prevalence of MIH led us to investigate a possible relationship between both events.Rats were orally exposed daily to low dose of bisphenol A (BPA), genistein, vinclozol...