Endocrine Abstracts

ESE Young Investigator AwardIntroduction: GH and IGF1 are thought to promote breast carcinogenesis as circulating levels of GH/IGF1 are positively correlated with breast cancer risk in epidemiologic studies, and mouse models with developmental GH/IGF1 deficiency or resistance are less susceptible to breast cancer development. However, no studies have shown that high levels of circulating GH/IGF1 can promote mammary tumorigenesis. In this...

Pituitary tumors are most usual intracranial tumors, displaying hormonal hyper-secretion with in some cases a sustained cell proliferation. The somatotroph adenomas are characterised by a GH hypersecretion. The current treatments are based on somatostatinergic or dopaminergic agonists. Unfortunately, there is steel 50% of patients, which remain insensitive to these treatments. The aim of our work is to find a pharmacological alternative to treat the patients resistant to the c...

The gonadotrophin receptors, LH receptor (LHR) and FSH receptor (FSHR) are G-protein coupled receptors, vital in regulating reproductive functions. During the follicular phase of the ovarian cycle, FSHR and LHR are separately localised to discrete cellular compartments, granulosa and theca cells respectively, where they control steroidogenesis and follicle maturation. However, as the follicle develops, LHR expression is induced in granulosa cells, resulting in temporary co-exp...

Introduction: 15% of pituitary tumors are considered as aggressive based on resistance to conventional treatment. Less than 40% of these cases respond to temozolomide treatment underlining the need for new therapeutic options. The PI3K/Akt/mTOR pathway, upregulated in different pituitary tumors subtypes, can be targeted by different drugs in particular BKM 120, a pure PI3K inhibitor, and BEZ235, a dual PI3K/mTOR inhibitor.Objective: To study the anti-tum...

Introduction: The effect of conventional somatostatin agonists (SA) on somatotroph pituitary adenomas is primarily mediated by somatostatin receptors (sstr) subtype 2. Sstr expression has been proposed as a prognostic marker for response to medical therapy. Earlier studies have shown lower sstr2a expression in SA treated adenomas, but selection bias could not be excluded.Objective: To assess the effect of SA on the immunohistochemical expression of sstr2...

Introduction: Hyponatremia (HN) is the most common electrolyte disorder of hospitalized patients (pts). It occurs in up to 28% of in-pts, increases the in hospital risk of death by 1.47 fold, and is associated with significantly higher mortality risk following discharge. The HN Registry is the first large scale, international effort to document the clinical characteristics, treatments used, and impact of HN in hospital settings.Methods: After informed co...