Searchable abstracts of presentations at key conferences in endocrinology
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15th European Congress of Endocrinology

Oral Communications

Pituitary & Molecular Endocrinology

ea0032oc1.1 | Pituitary & Molecular Endocrinology | ECE2013

The consequences of changing endogenous GH/IGF1 levels on carcinogen-induced mammary gland tumorigenesis are dependent on metabolic status in mice

Gahete Manuel D , Cordoba-Chacon Jose , Lantvit Daniel D , Perez-Jiminez Francisco , Lopez-Miranda Jose , Swanson Steven M , Castano Justo P , Luque Raul M , Kineman Rhonda D

ESE Young Investigator AwardIntroduction: GH and IGF1 are thought to promote breast carcinogenesis as circulating levels of GH/IGF1 are positively correlated with breast cancer risk in epidemiologic studies, and mouse models with developmental GH/IGF1 deficiency or resistance are less susceptible to breast cancer development. However, no studies have shown that high levels of circulating GH/IGF1 can promote mammary tumorigenesis. In this...

ea0032oc1.2 | Pituitary & Molecular Endocrinology | ECE2013

Involvement of the constitutive activity of the GHS-R1a (ghrelin G-protein coupled receptor) in the tumorigenesis of somatotroph adenomas

Mear Yves Louis , Donato Xavier Come , Blanchard Marie Pierre , Defilles Celine , Lisbonis Christophe , Barlier Anne , Enjalbert Alain , Thirion Sylvie

Pituitary tumors are most usual intracranial tumors, displaying hormonal hyper-secretion with in some cases a sustained cell proliferation. The somatotroph adenomas are characterised by a GH hypersecretion. The current treatments are based on somatostatinergic or dopaminergic agonists. Unfortunately, there is steel 50% of patients, which remain insensitive to these treatments. The aim of our work is to find a pharmacological alternative to treat the patients resistant to the c...

ea0032oc1.3 | Pituitary & Molecular Endocrinology | ECE2013

ESE Young Investigator Award

Chen Stanford , Jonas Kim , Huhtaniemi Ilpo , Hanyaloglu Aylin

The gonadotrophin receptors, LH receptor (LHR) and FSH receptor (FSHR) are G-protein coupled receptors, vital in regulating reproductive functions. During the follicular phase of the ovarian cycle, FSHR and LHR are separately localised to discrete cellular compartments, granulosa and theca cells respectively, where they control steroidogenesis and follicle maturation. However, as the follicle develops, LHR expression is induced in granulosa cells, resulting in temporary co-exp...

ea0032oc1.4 | Pituitary & Molecular Endocrinology | ECE2013

BKM120, a pure PI3K inhibitor: a promising treatment for aggressive pituitary tumors or pituitary carcinomas

Auger Carole , Rachwan Alexa , Chanal Marie , Raverot Veronique , Chevallier Pascale , Trouillas Jacqueline , Raverot Gerald

Introduction: 15% of pituitary tumors are considered as aggressive based on resistance to conventional treatment. Less than 40% of these cases respond to temozolomide treatment underlining the need for new therapeutic options. The PI3K/Akt/mTOR pathway, upregulated in different pituitary tumors subtypes, can be targeted by different drugs in particular BKM 120, a pure PI3K inhibitor, and BEZ235, a dual PI3K/mTOR inhibitor.Objective: To study the anti-tum...

ea0032oc1.5 | Pituitary & Molecular Endocrinology | ECE2013

Differential effect of octreotide treatment on expression of sstr2a, 3 and 5 in somatotroph adenomas

Heck Ansgar , Casar-Borota Olivera , Ramm-Pettersen Jon , Schulz Stefan , Bollerslev Jens

Introduction: The effect of conventional somatostatin agonists (SA) on somatotroph pituitary adenomas is primarily mediated by somatostatin receptors (sstr) subtype 2. Sstr expression has been proposed as a prognostic marker for response to medical therapy. Earlier studies have shown lower sstr2a expression in SA treated adenomas, but selection bias could not be excluded.Objective: To assess the effect of SA on the immunohistochemical expression of sstr2...

ea0032oc1.6 | Pituitary & Molecular Endocrinology | ECE2013

Management of euvolemic hyponatremia attributed to SIADH in the hospital: interim results from a prospective, observational, multi-center, global registry

Peri Alessandro , Verbalis Joseph , Greenberg Arthur , Johannsson Gudmundur , Ball Steven , Jorgensen Jens Otto , Chiodo Joseph

Introduction: Hyponatremia (HN) is the most common electrolyte disorder of hospitalized patients (pts). It occurs in up to 28% of in-pts, increases the in hospital risk of death by 1.47 fold, and is associated with significantly higher mortality risk following discharge. The HN Registry is the first large scale, international effort to document the clinical characteristics, treatments used, and impact of HN in hospital settings.Methods: After informed co...