Searchable abstracts of presentations at key conferences in endocrinology
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15th European Congress of Endocrinology

Poster Presentations

Thyroid cancer

ea0032p1077 | Thyroid cancer | ECE2013

Association acromegaly and thyroid cancer

Achir Samia , Hasbellaoui Fella , Khalifa Anissa , Semrouni Mourad

Introduction: Acromegaly is a chronic disease caused by hypersecretion of GH and IGF1, it is associated with a high risk of cancer, however the excess incidence of thyroid cancer remains controversial, we report four cases.Patients and methods: The diagnosis of acromegaly has been placed on a dosage of GH and IGFI, the diagnostic of carcinoma is based on histological study of the surgical specimen.Results: The sex ♀ predomina...

ea0032p1078 | Thyroid cancer | ECE2013

Double primary carcinoma – a case of coexisting papillary thyroid carcinoma and pulmonary adenocarcinoma

Barrera Jerome , Jasul Gabriel

A 49 year-old Filipino male presented at the emergency room because of progressive dyspnea. He was diagnosed with papillary thyroid carcinoma by fine needle aspiration biopsy of his 7×5 cm thyroid mass 3 months prior to his current consultation. He was scheduled to undergo total thyroidectomy but he opted to postpone his surgery due to intermittent cough. On admission, a pulmonary mass with pleural effusion on the right was noted on chest radiograph. He was considered to ...

ea0032p1079 | Thyroid cancer | ECE2013

Rac1B: a prognostic marker for papillary thyroid carcinoma?

Silva Ana Luisa , Carmo Francisca , Pereira Teresa , Cabrera Rafael Adame , Bugalho Maria Joao

Introduction: Identification of molecular markers with a reliable prognostic value may greatly improve the management of patients with papillary thyroid carcinoma (PTC). Rac1b, a hyperactive splice variant of the small GTPase Rac1, was found to be overexpressed in colorectal, breast and lung cancer. It has been shown to sustain tumor cell survival in colorectal cancer and was reported to have a key role in the malignant progression of breast and lung tumors. The Rac1b tumorige...

ea0032p1080 | Thyroid cancer | ECE2013

A single-center, open-label, phase II, proof-of-concept study with pasireotide long-acting release in patients with progressive medullary thyroid cancer: 6-month evaluation

Faggiano Antongiulio , Ferolla Piero , Vitale Giovanni , Del Prete Michela , Ramundo Valeria , Esposito Raffaella , Marotta Vincenzo , Marciello Francesca , Carratu Anna Chiara , Camera Luigi , Fonti Rosi , Colao Annamaria

Introduction: Medullary thyroid cancer (MTC) is a well-differentiated neuroendocrine tumor in which somatostatin receptor (sst) expression is higher for sst1 and sst5 than for sst2. This may explain why the available sst2–selective analogues do not work in these patients and why pasireotide (SOM230), a novel, multi-receptor targeted somatostatin analogue with high-binding affinity for sst1,2,3 and sst5 coul...

ea0032p1081 | Thyroid cancer | ECE2013

A novel multi-target pyrazolopyrimidine derivative with anti-neoplastic properties, CLM29, is active against medullary thyroid cancer in vitro and in vivo

Fallahi Poupak , Ferrari Silvia Martina , Bocci Guido , La Motta Concettina , Ruffilli Ilaria , Di Domenicantonio Andrea , Corrado Alda , Mancusi Caterina , Danesi Romano , Da Settimo Federico , Miccoli Paolo , Antonelli Alessandro

Introduction: CLM29, a pyrazolo[3,4-d]pyrimidine compound, inhibits several targets (including the RET tyrosine kinase, epidermal growth factor receptor, vascular endothelial growth factor receptor and has an anti-angiogenic effect). Recently it has been shown to inhibit proliferation and migration in primary papillary dedifferentiated thyroid cancer cells. The aim of this study is to evaluate the anti-tumor activity of CLM29 in medullary thyroid cancer (MTC).<p c...

ea0032p1082 | Thyroid cancer | ECE2013

Association of pre-miR-146a rs2910164 GG genotype with papillary thyroid cancer: a new case–control study on two adjacent genes on chromosome 5, pre-miR-146a and PTTG1.

Marino Marco , Cirello Valentina , Gnarini Valentina , Pignatti Elisa , Casarini Livio , Diazzi Chiara , Rochira Vincenzo , Cioni Katia , Madeo Bruno , Simoni Manuela , Fugazzola Laura

Introduction: Papillary thyroid carcinoma (PTC) is the most common endocrine malignancy, with a steadily increasing incidence in the last few decades worldwide. Studies revealed the predisposition to PTC by the heterozygous state of rs2910164 within the precursor of microRNA146a. Interestingly, on the same chromosome, 40Kb separate the pre-miR-146a from the pituitary tumour transforming gene (PTTG1), a proto-oncogene involved in thyroid carcinomas. A genome-w...

ea0032p1083 | Thyroid cancer | ECE2013

Circulating microRNAs may help to differentiate malignant from benign thyroid nodules

Pilli Tania , Cardinale Sandro , Cantara Silvia , Busonero Giulia , D'Angeli Francesco , Pacini Furio

Introduction: MicroRNAs (miRNAs) are small, endogenous, non-coding RNAs that act as negative regulators of gene expression. The miRNA expression is impaired in many types of human cancer including thyroid cancer. The tissue profile of miRNAs has been shown to be useful for differentiating benign from malignant thyroid nodules, however attainment of tissue samples requires an invasive procedure while blood sampling is minimally invasive and easy to obtain. The aim of this study...

ea0032p1084 | Thyroid cancer | ECE2013

Inhibition of proliferation in anaplastic thyroid cell lines

Rodrigues Joana , Rodriguez Angela , Perez Sihara , Barreiro Francisco , Cameselle-Teijeiro Jose , Rodriguez Maria , Bravo Susana , Alvarez Clara

Introduction: Our group has a bank of human primary thyroid cultures (BANTTIC) obtained from patients. All are individual cultures specifically genotyped and phenotyped. We believe of great interest the search for biomarkers in these cultures using differential proteomic analysis.We have applied differential proteomics using 2D-PAGE coupled to MALDI-TOF-TOF-MS. We have compared benign pathologies (normal thyroid and Pendred’s syndrome) and different...

ea0032p1085 | Thyroid cancer | ECE2013

Pre-existing autoimmune thyroid disease may influence the course of the disease in differentiated thyroid carcinoma patients

Athanasiadou Anastasia , Saltiki Katerina , Rentziou Gianna , Papageorgiou George , Anastasiou Eleni , Alevizaki Maria

Introduction: Differentiated thyroid carcinoma (DTC) has generally a good prognosis and is associated with prolonged survival. A minority of patients may have persistent disease and rarely aggravation during f/u. We investigated factors which may influence the persistence of disease in patients who had undergone ablation with I131.Patients and methods: 903 DTC patients were referred in our center from 1968 to 2012. Five hundred and forty-one (...

ea0032p1086 | Thyroid cancer | ECE2013

Evaluation of treatment approaches to the sporadic and hereditary medullary thyroid carcinoma in Turkey

Yuksel Bagdagul , Aydogan Berna Imge , Gursoy Alptekin , Tuna Mazhar Muslum , Basaran Mehtap Vardar , Akkurt Aysen , Ertorer M Eda , Aydin Kadriye , Guldiken Sibel , Simsek Yasin , Karaca Zuleyha , Yilmaz Merve , Akturk Mujde , Anaforoglu Inan , Kebapci Nur , Taslipinar Abdullah , Kulaksizoglu Mustafa , Berker Dilek , Erbas Tomris , Erdogan Murat Faik

Introduction: RET mutation analysis has a critical importance for determining clinical approach to hereditary medullary thyroid carcinoma (MTC). The current guidelines recommends to determine the timing of prophylactic thyroidectomy depending on the risk stratification, mainly decided by the type of the mutation.Methods: Society of Endocrinology and Metabolism of Turkey (SEMT) sponsored ret genetic screening between July 2008 and January 2012 in 513 pati...

ea0032p1087 | Thyroid cancer | ECE2013

Sentinel lymph node biopsy in thyroid carcinoma and decision for selective modified radical neck dissection

Dzodic Radan , Markovic Ivan , Djurisic Igor , Buta Marko , Jevric Marko , Oruci Merima , Inic Zorka , Milovanovic Zorka , Pupic Gordana

Background: The accuracy of sentinel lymph node biopsy (SLNB) in decisions for surgical management of lymph nodes in thyroid carcinoma (TC) was demonstrated in a few previous studies. SLNB was started in good selected cases of medullary TC (MTC) and it is a promising method. Its application to avoid prophylactic neck dissectionAim: To determine whether SLNB of first draining node/s in jugulo-carotid chain is accurate technique to select patients with tru...

ea0032p1088 | Thyroid cancer | ECE2013

Pre-miR146a expression profiling of follicular thyroid carcinoma

Pignatti Elisa , Vighi Eleonora , Roncati Luca , Kara Elda , Porcheddu Eleonora , Magnani Elisa , Rochira Vincenzo , Maiorana Antonino , Carani Cesare , Simoni Manuela

Introduction: Follicular thyroid carcinomas (FTC) are the second most common type of thyroid malignancy. Micro-RNAs (miRNAs) are a new class of small, noncoding RNAs whose expression is deregulated in many types of human cancers and may lend novel clues to FTC genesis. Pre-miR146a represents one of the most up-regulated miRNAs in papillary thyroid carcinomas (PTC) and a SNP (rs2910164), identified in pre-miR146a, contributes to genetic predisposition to PTC, but data on FTC ar...

ea0032p1089 | Thyroid cancer | ECE2013

68Ga-DOTA-NOC PET/CT role in the follow-up of patients with medullary thyroid carcinoma

Couto Joana , Martins Raquel , Lucena Ines , Menezes Joana , Santos Ana Paula , Rodrigues Elisabete , Duarte Hugo , Torres Isabel

Introduction: About 50% of patients with medullary thyroid carcinoma (MTC) have persistent or recurrent disease after surgery.For a calcitonin (ct) value greater than 150 pg/ml, it is suggested by international guidelines performing additional imaging exams (AIE) for evaluating the presence of distant metastasis. It is often difficult to assess the presence of nodal disease and secondary liver lesions (often miliary) by ‘morphological’ imaging ...

ea0032p1090 | Thyroid cancer | ECE2013

Distribution of ret proto-oncogene mutations among Turkish familial medullary thyroid cancer/multiple endocrine neoplasia 2 patients

Yuksel Bagdagul , Aydogan Berna Imge , Gursoy Alptekin , Tuna Mazhar Muslum , Basaran Mehtap Navdar , Akkurt Aysen , Ertorer Eda , Aydin Kadriye , Guldiken Sibel , Simsek Yasin , Karaca Zuleyha , Yilmaz Merve , Akturk Mujde , Anaforoglu Inan , Kebapci Nur , Taslipinar Abdullah , Kulaksizoglu Mustafa , Berker Dilek , Erbas Tomris , Faik Erdogan Murat

Introduction: TURK-MEN study was carried out to evaluate the mutational analysis of so called sporadic MTC patients between 1994 and 2005. Our aim was to evaluate the ret genetic screening results, distribution of mutations among so called sporadic and hereditary MTC patients in Turkey between 2008 and 2012.Methods: Society of Endocrinology and Metabolism of Turkey (SEMT) sponsored ret genetic screening between July 2008 and January 2012 in 513 patients....

ea0032p1091 | Thyroid cancer | ECE2013

Treating refractory thyroid cancer in the era of multitarget tyrosine kinase inhibitors

Mathiopoulou Lemonia , Boudina Maria , Chrisoulidou Alexandra , Mandanas Stylianos , Margaritidou Efterpi , Georgopoulos Konstantinos , Pazaitou-Panayiotou Kalliopi

Introduction: Tyrosine kinase inhibitors (sorafenib and sunitinib) have been used in treating refractory cases of thyroid cancer. The aim of our present study was to assess the efficacy of these agents in patients with refractory and progressive thyroid cancer, regarding patients’ quality of life, adverse events and response ratesPatients and methods: We retrospectively analyzed data of adult patients with differentiated and medullary thyroid cancer...

ea0032p1092 | Thyroid cancer | ECE2013

Mutations and somatic changes in the genotype of rs2910164 in pre-miR146a are frequent in follicular thyroid carcinoma

Vighi Eleonora , Pignatti Elisa , Roncati Luca , Rochira Vincenzo , Kara Elda , Madeo Bruno , Magnani Elisa , Maiorana Antonino , Carani Cesare , Simoni Manuela

Introduction: The mechanism underlying the development of follicular thyroid carcinoma (FTC), the second commonest thyroid tumor, is still unknown. An interesting hypothesis is that changes in the expression of multiple regulatory RNA (miR) genes may be a major mechanism in thyroid carcinogenesis. For example, several studies suggested that SNP rs2910164 in the pre-miR146a, a precursor of miR146a, might be correlated to papillary carcinoma. The aim of this study was the evalua...

ea0032p1093 | Thyroid cancer | ECE2013

Interobserver agreement of thyroid imaging reporting and data system and realtime elastography for the assessment of thyroid nodules

Friedrich-Rust Mireen , Meyer Gesine , Dauth Nina , Berner Christian , Herrmann Eva , Schroeter Hartmut , Holzer Katharina , Voelkl Lisa , Zeuzem Stefan , Bojunga Joerg

Introduction: Work-up of thyroid nodules remains challenging. Thyroid imaging reporting and data system (TIRADS) has been developed to improve patient management and cost-effectiveness by avoiding unnecessary fine needle aspiration biopsy (FNAB) in patients with thyroid nodules. However, since its publication in JCEM (2009) its clinical use is still very limited and its practicability in clinical practice is questioned. Realtime-elastography (RTE) enables the determination of ...

ea0032p1094 | Thyroid cancer | ECE2013

Medullary thyroid carcinoma – a narrow surgical window

Dobrescu Ruxandra , Iacob Diana , Stanescu Bogdan , Badiu Corin

Introduction: Occurring sporadically or as part of a familial syndrome, medullary thyroid carcinoma (MTC) is insidious in onset, aggressive in behavior and invariably a challenge to the clinician and surgeon.Objective: To define the relationship between biochemical parameters, disease progression, and treatment outcome in patients with MTC.Patient and methods: We studied 35 patients (11 men, 24 women) aged 50.9±14.8 years, adm...

ea0032p1095 | Thyroid cancer | ECE2013

Prognostic value of postoperative thyroglobulin levels for papillary thyroid carcinoma

Tseng Fen-Yu , Yen Ruoh-Fang

Background: Patients with papillary thyroid carcinoma may have repeated recurrence. This study evaluated the prognostic value of postoperative thyroglobulin levels.Method: From 1998 to 2009, patients with papillary thyroid carcinoma were recruited by medical chart review. The pathology report, postoperative thyroglobulin levels, radioactive iodine (RAI) ablation and scan, and re-operation were abstracted.Results: A total of 453 pat...

ea0032p1096 | Thyroid cancer | ECE2013

Radioactive iodine therapy in papillary thyroid carcinomas staged as T1

Marques Pedro , Macedo Daniel , Pereira Joana , Vieira Margarida , Leite Valeriano , Bugalho Maria

Introduction: 131I therapy in patients with papillary thyroid carcinomas (PTC) ≤2 cm and without extrathyroidal extension (T1) depends on multifactorial analysis: age, multifocality, histological criteria, lymph node or systemic metastasis. The study purposes were analyze PTC-T1 and compare the groups treated only with surgery vs combined therapy (surgery and 131I).Methods: Retrospective analysis of clinical files of PTC-T1 pa...

ea0032p1097 | Thyroid cancer | ECE2013

The role of radioiodine SPECT/CT in differentiated thyroid cancer

Mezosi Emese , Bajnok Laszlo , Rucz Karoly , Weninger Csaba , Schmidt Erzsebet , Szabo Zsuzsanna , Szekeres Sarolta , Zambo Katalin

Introduction: Beside remnant ablation and treatment of known metastases, radioiodine treatment of differentiated thyroid cancer is suitable for the discovery of unknown or suspected metastatic disease. In this study, the clinical utility of SPECT/CT, a hybrid imaging method was evaluated after radioiodine therapy.Patients and methods: Between July 2007 and March 2012, 260 investigations were performed at 188 patients. Male:female ratio was 47:141. Every ...

ea0032p1098 | Thyroid cancer | ECE2013

Examination of CYP24A1 and ‘three-genes' (SFN, MRC2, HMGA2) expressions in different pathological subgroups of human papillary thyroid cancer

Balla Bernadett , Kosa Janos , Tobias Balint , Takacs Istvan , Nagy Zsolt , Horvath Peter , Horanyi Janos , Szekely Eszter , Jaray Balazs , Lakatos Peter

Background: The ’three-genes’ (SFN, MRC2, HMGA2) might have direct role in various cancer progression and malignant thyroid conditions. We previously reported an increased expression of 1,25-D3 neutralizing enzyme, (24-hydroxylase – CYP24A1) as a possible novel marker gene in thyroid carcinoma. In this study, we examined the transcription activity of CYP24A1 and ‘three-genes’ in four functional subgroups of papillary thyroid tumor (PTC)....

ea0032p1099 | Thyroid cancer | ECE2013

The prevalence, the tumorigenic role and the functional implications of rare BRAF alterations in a cohort of Italian patients with thyroid carcinomas

Pezzani Raffaele , Barollo Susi , Cristiani Andrea , Redaelli Marco , Zambonin Laura , Rubin Beatrice , Bertazza Loris , Zane Mariangela , Mucignat-Caretta Carla , Bulfone Alessandro , Pennelli Gianmaria , Rosa Pelizzo Maria , Mantero Franco , Moro Stefano , Mian Caterina

Background: Papillary thyroid carcinoma (PTC) is the most common malignant tumor of the thyroid gland, accounting for 74–80% of all thyroid cancers. The T1799T>A transversion is an activating mutation of the BRAF oncogene that is common in conventional PTC and specific to it.Aims: To study the prevalence, tumorigenic role and biomolecular implications of rare BRAF variants in a large cohort of patients.Study desig...

ea0032p1100 | Thyroid cancer | ECE2013

Thyroglobulin in fine-needle aspiration wash-out diagnostic performance: a meta-analysis

Grani Giorgio , Fumarola Angela

Introduction: Differentiated thyroid cancer (DTC) has an excellent prognosis. However, DTC frequently metastasizes to cervical lymph nodes (CLN). In case of suspicious ultrasonography findings, the fine-needle aspiration (FNA) is usually required to confirm or exclude metastasis. The combination of FNA-cytology and thyroglobulin (Tg) measurements in the needle washout has been reported to increase the sensitivity of FNA in identifying lymph node metastases from DTC, particular...

ea0032p1101 | Thyroid cancer | ECE2013

Thyroglobulin levels in the washout of lymph node fine-needle aspirate on patients with previous history of differentiated thyroid cancer

Gouveia Sofia , Ribeiro Cristina , Paiva Sandra , Alves Marcia , Saraiva Joana , Moreno Carolina , Guelho Daniela , Leitao Fatima , Carrilho Francisco

Introduction: Our aim was to determine the comparable value of thyroglobulin in the washout of lymph node fine-needle aspirate (FNATg) and fine-needle aspiration biopsy (FNAB).Materials and methods: We included 29 patients (37 FNAB) with history of differentiated thyroid cancer who underwent total thyroidectomy and were found to have suspicious cervical lymph nodes during follow-up. The referred population was evaluated on what concerns to gender, age, s...

ea0032p1102 | Thyroid cancer | ECE2013

The diagnostic accuracy of ultrasound-guided fine needle aspiration biopsy (FNAB) in thyroid nodules 3 cm and above in size and sonographic feature differences between malignant and benign nodules

Ucler Rifki , Usluogullari Celil Alper , Ali Tam Abbas , Ozdemir Didem , Yalcin Samet , Kiyak Gulten , Ersoy Pamir Eren , Guler Gulnur , Ersoy Reyhan , Cakir Bekir

Introduction: Nodule diameter was considered to be related with thyroid cancer. Whether under ultrasound (US) guidance or not, FNAB has some limitations particularly in big nodules. In this study, we aimed to evaluate diagnostic value of US-FNAB in nodules bigger than 3 cm or more. We also compared ultrasonographical features of benign and malignant nodules.Material and methods: Data of 267 patients operated for nodulary goiter were screened retrospectiv...

ea0032p1103 | Thyroid cancer | ECE2013

Evaluation of whole-body scan, stimulated thyroglobulin after thyroxine withdrawal vs recombinant TSH administration according to the risk groups of tumor recurrence

Sahin Mustafa , Aydogan Berna Imge , Yuksel Bagdagul , Erdogan Murat Faik , Gullu Sevim , Emral Rifat , Corapcioglu Demet , Baskal Nilgun , Uysal Ali Riza

Background: Recombinant human thyroid-stimulating hormone (rhTSH)-stimulated serum thyroglobulin (Tg) (s-Tg) and (131)I whole-body scanning (WBS) are supposed to provide equal diagnostic information with thyroxine withdrawal (THW) at follow-up thyroid cancer patients without the symptoms of hypothyroidism. We aimed to compare the WBS and s-Tg levels after thyrogen injection and thyroid hormone withdrawal for tumor recurrence/persistance according to the risk groups.<p clas...

ea0032p1104 | Thyroid cancer | ECE2013

Stimulated serum Tg ≥0.285 ng/ml in anti-Tg(−) cases had 3.087 times increased likelihood of recurrence of differentiated thyroid cancer: a single center experience

Yikilmaz Aysun Senturk , Mousa Umut , Nar Asli

Thyroid cancers constitute 2% of all cancer cases most of which are differentiated. Tumor size, lymph node metastases and thyroglobulin levels (Tg) in the follow-up period are among the major factors responsible for recurrence. In this study, we aimed to review our series of differentiated thyroid cancers and establish the risks of recurrence.This study was carried out through a retrospective analysis of 393 differentiated thyroid cancer cases that were ...

ea0032p1105 | Thyroid cancer | ECE2013

Papillary thyroid carcinoma with focal hobnail features

Ryzhenkova Marija Igorevna , Furminskaia Elena Yurevna , Abrosimov Alexander Yurevich , Shinkarkina Anna Petrovna

Background: Papillary thyroid carcinoma (PTC), the most common endocrine malignancy, is a tumor of indolent biological and clinical behaviour that usually has a good prognosis. Only a small percentage of patients are affected by aggressive variants of PTC: tall, columnar cell and diffuse sclerosing variants. These aggressive tumor subtypes are characterized by higher rate of local recurrence, regional and distant metastases than classic papillary PTC. Recently another clinical...

ea0032p1106 | Thyroid cancer | ECE2013

Serum calcitonin, thyrotropin, and goiter

Grani Giorgio , D'Alessandri Mimma , Del Sordo Marianna , Carbotta Giovanni , Vitale Martina , Fumarola Angela

Objective: Recent papers reported that basal calcitonin (CT) level may be related to thyroid volume. This study aims to evaluate if this finding is confirmed in patients undergoing ultrasonography-guided fine-needle aspiration cytology (FNAC) for thyroid nodules.Design: Retrospective university-center study.Methods: From February 2010 to September 2012, 561 patients underwent ultrasonography-guided FNAC and a complete evaluation in...

ea0032p1107 | Thyroid cancer | ECE2013

Incidental thyroid cancer frequency in total thyroidectomy for the graves disease patients and the effect of the presence of nodules on malignity rates

Tam Abbas Ali , Kaya Cafer , Balkan Fevzi , Ersoy Pamir Eren , Yalcin Samet , Kiyak Gulten , Guler Gulnur , Ersoy Reyhan , Cakir Bekir

Introduction: Our objective for the current review was to inquire the thyroid cancer frequency rate within the patients who have had total thyroidectomy procedure for definitive Graves’ disease treatment and to evaluate the contribution of the presence of nodules to malignity rates.Materials and methods: The present study was conducted by scanning the data of 214 patients who were applied total thyroidectomy for permanent Graves disease treatment, r...

ea0032p1108 | Thyroid cancer | ECE2013

Detecting somatic oncogene mutations in FNA samples of cold nodules in Hungary

Tobias Balint , Balla Bernadett , Kosa Janos P , Horanyi Janos , Takacs Istvan , Nagy Zsolt , Horvath Peter , Jaray Balazs , Szekely Eszter , Istok Roland , Szekely Tamas , Lakatos Peter

Cold nodules are one of the most common findings on scintigraphic examinations of the thyroid gland. About 5–10% of these nodules turn out to be histologically malignant. Our aim was to examine some somatogenetic alterations associated with thyroid cancer in FNA samples of the thyroid. These alterations included single nucleotide mutations (BRAF, HRAS, NRAS, KRAS) and genetic translocations (RET/PTC1, RET/PTC3, PAX8ex7/PPARgamma, PAX8ex9/PPARgamma). The SNPs were tested b...

ea0032p1109 | Thyroid cancer | ECE2013

Predictive value of preablation stimulated thyroglobulin in differentiated thyroid cancer

Sanchez Inmaculada Prior , Moreno Ma Angeles Galvez , Jimenez Carmen Tenorio , Exposito Ma Rosa Alhambra , Ortega Raul Ruiz , Ortega Estefania Moreno , Vallejo Casas Juan Antonio , Lopez Pedro Benito

Background: Previous studies have suggested that serum thyroglobulin (Tg) levels at the time of 131I remnant ablation just after thyroidectomy, could be a prognostic tumor marker in differentiated thyroid cancer (DTC).Objective: The aim of this study was to evaluate if serum preablation Tg in the earliest postoperative period could be useful for predicting persistence or recurrence of disease.Methods: This study was a retrospective...

ea0032p1110 | Thyroid cancer | ECE2013

Concurrent follicular and columnar cell variants of papillary thyroid carcinoma characterized by different BRAF status and metastatic properties: a case review

Abrosimov Alexander , Shinkarkina Anna

Papillary thyroid carcinoma (PTC) is a malignant tumour of follicular cell origin that is characterized by a broad diversity of histological variants. A genesis of multifocal PTC may be explained by both intrathyroid tumour dissemination and multiple focuses of tumour origination. A combination of two different focuses of PTC characterized by various molecular alterations of tumour cells in one thyroid could be rarely occurred. Follicular variant has similar clinical behaviour...

ea0032p1111 | Thyroid cancer | ECE2013

Thyroglobulin as an early marker of persistent/recurrent disease in patients with differentiated thyroid carcinoma (DTC)

Aulinas Anna Maso , Colom Cristina Comi , Mendoza Lilian Mathison , Alcantara Valeria Aragon , Mato Eugenia Matute , Corcoy Rosa Pla , Gich Ignasi Saladich , Rodriguez Jose Espinosa , Gonzalez Cintia Blanco

Introduction: Several clinical and molecular markers can be used to establish risk at the time of diagnosis in DTC. Thyroglobulin (Tg), which is essential in follow up, could be an early marker to identify risk patients. Around 25% of patients require 18 months or longer to have indetectable Tg. The presence of Tg antibodies (TgAb) invalidate the follow up of DTC via Tg and this is usually associated with a poor prognosis.Aim: To evaluate the role of Tg ...

ea0032p1112 | Thyroid cancer | ECE2013

Ultrasound guided enolization as a therapeutic alternative in local recurrences of papillary thyroid carcinoma

Hernandez Tomas Martin , Rodriguez Jose Perez , Rivera Natividad Gonzalez , Cuadro Alberto Torres , Garcia Clara Garcia , Manzano Virginia Martin

Introduction and objectives: Multiple surgeries are associated with many complications in the local recurrence of papillary thyroid carcinoma. Our objective is to evaluate the efficiency of the enolization in the recurrent metastatic cervical lymph nodes in patients with limited nodal disease.Material and methods: We studied 13 patients (six males and seven females) with a mean age of 43±14.4 years with papillary thyroid carcinoma intervened (total ...

ea0032p1113 | Thyroid cancer | ECE2013

Liquid preparation cytology for evaluation of thyroid nodules

Keyhani Elahe , Sharghi Sassan A , Amini Rana , Sharghi Sina A , Larijani Bagher

Introduction: FNA (fine needle aspiration) is a highly sensitive and specific procedure in evaluating of thyroid nodules. There are several options for processing the FNA specimen such as direct smears, cell block preparations (CBP) and liquid base preparations (LBP); the latter has become more popular due to its easy transport, fast protocol and also the possibility to study different parts of the specimen. In this study, we compare the results of cell block and liquid base p...

ea0032p1114 | Thyroid cancer | ECE2013

Prevalence of hypovitaminosis D in patients with papillary thyroid carcinoma (PTC)

Kowalska Aldona , Gasior-Perczak Danuta , Palyga Iwona , Siolek Monika , Sluszniak Anna , Mezyk Ryszard , Gozdz Stanislaw

Introduction: The correct 25-hydroxy vitamin D (25(OH)D) level plays a key role in the proper supply of vitamin D for the organism. Vitamin D deficiency may lead to an increased risk of development of various neoplasms, including papillary thyroid carcinoma (PTC).Aim: Evaluation of the prevalence of vitamin D deficiency in patients with PTC and analysis of the relation between 25(OH)D levels and age, sex, place of living, severity of the disease, and pre...

ea0032p1115 | Thyroid cancer | ECE2013

Primary thyroid lymphoma – report of four cases

Couto Joana , Martins Raquel , Santos Ana Paula , Leite Luis , Martins Angelo , Lencastre Luis , Sanches Cristina , Jacome Manuel , Henrique Rui , Torres Isabel

Introduction: Primary thyroid lymphoma (PTL) is responsible for 0.6–5% of all cases of thyroid cancer and less than 2% of all extranodal lymphomas. PTL is more common in elderly women and are commonly of B-cell origin. Current treatment regimens for PLC consist of chemotherapy and external beam radiation. Surgery plays an important role, including the control of symptoms in large obstructive lymphomas.Aims and methods: Retrospective data review of p...

ea0032p1116 | Thyroid cancer | ECE2013

Treatment, follow up and prognostic factors of papillary microcarcinoma

Usluogullari Alper Celil , Onal Eda Demir , Ozdemir Elif , Ucler Rifki , Kiyak Gulten , Ersoy Pamir Eren , Yalcin Samet , Guler Gulten , Ersoy Reyhan , Cakir Bekir

Introduction: The incidence rate of papillary thyroid microcarsinoma (PTMC) has almost doubled during the recent years but treatment and follow up is still a matter of debate. In this study we aimed to analyze clinical and histopathological risk factors at the time of diagnosis and to observe their implications for treatment, follow up and prognosis.Patients and methods: Two hundred forty-eight PTMC patients were included in this study. The age, sex, the...

ea0032p1117 | Thyroid cancer | ECE2013

Macrofollicular variant of papillary thyroid carcinoma: an uncommon entity

Gedik Arzu , Yilmaz Merve , Demir Tevfik , Durak Merih Guray , Ikiz Ahmet Omer , Kocdor Mehmet Ali , Ozdogan Ozhan , Bayraktar Firat , Comlekci Abdurrahman

Background: Macrofollicular variant (MV) is a rarely seen variant of papillary thyroid carcinoma (PTC). We herein present clinical characteristics of four patients carrying this variant of PTC. Case 1: 62-year-old female patient underwent total thyroidectomy (TT) due to euthyroid multinodular goiter (MNG) with a cytology of ‘indeterminate nodule’. The pathology revealed ‘papillary thyroid microcarcinoma MV with a diameter of 8×6 mm, without capsule or lymph...

ea0032p1118 | Thyroid cancer | ECE2013

Postoperative stimulated thyroglobulin levels in thyroidectomized patients with differentiated thyroid cancer

Batanero Ricardo , Elias Estela , Molina Ana Rosa , Gaztambide Sonia , Santamaria Javier

Introduction: The presence of undetectable serum levels of stimulated thyroglobulin (Tg) with negative imaging tests is the criterion used to define remission in low-risk differentiated thyroid cancer (DTC). Most guidelines recommend 131-I ablation after thyroidectomy to remove any possible residual thyroid tissue. Our aim was to know how often undetectable Tg levels are achieved before ablation to avoid unnecessary radiation treatments.Patients and meth...

ea0032p1119 | Thyroid cancer | ECE2013

Angiosarcoma of the thyroid gland: a case report

Puca Entela , Koza Kadir Burak , Gozalan Ugur , Erekul Selim , Lumi Ema , Puca Edmond

Angiosarcoma of the thyroid is a rare and aggressive primary malignant tumor of the thyroid: it rarely occurs in that organ and most of these occur mainly in patients from the mountainous Alpine regions. We report a case of 68-year-old female who presented at our hospital with a rapidly enlarging neck mass associated with compressive symptoms. On clinical examination, the thyroid gland appeared firm during the acts of deglutition. The results of thyroid function tests were for...

ea0032p1120 | Thyroid cancer | ECE2013

MIBI – spect scintigraphy in the presurgical assessment of thyroid lesions with indeterminate cytology

Goldin Elena , Klein Pinchas , Sopov Vladimir , Mekhmandarov Sergey , Avior Galit , Meir Alona , Chouraqui Pier , Jaffe Anat

Introduction: Thyroid lesions with indeterminate cytology represent about 15% of all thyroid biopsies with the risk of malignancy 15–30%. So the identification of low-risk patients in this group is very important.Few studies evaluated thyroid Tc-99m MIBI [MIBI] scan as a tool for work-up of indeterminate cytology thyroid lesions. The negative predictive value of this test in excluding malignancy appears to be high (95%). But it is not used routinely...

ea0032p1121 | Thyroid cancer | ECE2013

Clinical and biochemical criteria for the prognosis of small medullary thyroid carcinomas

Saltiki Katerina , Rentziou Gianna , Vasileiou Vasiliki , Athanasiadou Anastasia , Anastasiou Eleni , Alevizaki Maria

Introduction: Recently, small medullary thyroid carcinomas (sMTCs) (≤1.5 cm) are frequently diagnosed, occasionally as incidental findings in surgical and autopsy specimens. Their clinical course varies. We examined whether tumor size is a predictor of clinical behavior.Patients and methods: One hundred and one sMTC patients (36.6% males, 47.1% familial) followed-up for 0.9–35 years. Patients were classified according to tumor size (cm) in gro...

ea0032p1122 | Thyroid cancer | ECE2013

Diagnostic validity of thyroid ultrasonography in thyroid nodules

Ram Nanik , Saima S , Ahmed Saqib , Anwer Zahid , Islam Najmul

Introduction: A thyroid ultrasound scan is recommended in the assessment of any suspected thyroid nodule. The ultrasound characteristics of nodules have been shown to be useful in assessing their malignant potential. The aim of this study is to determine diagnostic validity of thyroid ultrasound in differentiating benign and malignant thyroid nodule.Material and Methods: It was cross-sectional study, conducted at XXXX Hospital from August 2011 to July 20...

ea0032p1123 | Thyroid cancer | ECE2013

Histopathologic characterization of differentiated thyroid carcinoma in an area of Basque country

Vicente Ma Angeles Vicente , Polo Pilar Sierra , Gomez Carmen Cabrejas , Iregi IzasKun Olaizola , Cabrera Natalia Gonzalez , Gomez Clara Rosario Fuentes , Miguel Ma Angeles Anton

Background: The most common type of thyroid cancer is the well-differentiated thyroid carcinoma (DTC) and that includes papillary (PTC) and follicular carcinoma (FTC). The PTC would represent 50–90% and the FTC over 15–30%. Within the PTC, the most frequent is the classical variant (over 80%), followed by follicular variant (10%) and the rest of variants (<10%). Furthermore, there are differences between PTC and FTC in age at diagnosis, local extension, multicent...

ea0032p1124 | Thyroid cancer | ECE2013

A rare case of nonsecretory medullary thyroid carcinoma

Ferreira Florbela , Marcelino Mafalda , Wessling Ana , Nobre Ema , Leite Valeriano , Carmo Isabel

Introduction: Medullary thyroid carcinoma (MTC) is a rare form of thyroid cancer, making up about 3–5% of all cases. It is characterized by the synthesis and secretion of calcitonin (Ct). Measurement of Ct has low specificity but is a highly sensitive method for the detection of MTC. MTC with normal or only slightly elevated Ct is a rare occurrence and there are few such reports in the literature.Case report: A 61-year-old male patient was referred ...

ea0032p1125 | Thyroid cancer | ECE2013

Coexistent medullary thyroid carcinoma and multifocal papillary thyroid microcarcinoma in a patient with chronic autoimmune thyroiditis

Pascanu Ionela , Neagoe Radu , Capraru Oana , Borda Angela

Introduction: The association between medullary (MTC) and differentiated thyroid cancer (DTC, with the most frequent form of papillary thyroid carcinoma, PTC) is rare and can be observed in two main settings: a collision tumor (that is, a tumor with two separate and different components) or a mixed tumor showing dual differentiation.Case report: A 58-year-old woman, affected by euthyroid multinodular goiter came to our observation for a second opinion re...

ea0032p1126 | Thyroid cancer | ECE2013

BRAF V600E mutation in papillary thyroid cancer: clinical and pathological features. Is there any role in tailoring initial treatment?

Oleaga Amelia , Goni Fernando , Paja Miguel , Iglesias Natalia , Fuertes Elena , Lizarraga Aitzol , Palacios Angel Gomez , Elorza Ramon

Introduction: BRAF (V600E) mutation is the most frequent detected genetic change in papillary thyroid cancer (PTC) and its presence has been related to aggressive clinical and pathological features. Lymph node metastases (LNMx) are common in PTC and are associated with an increase in loco-regional recurrence. However, prophylactic lymph node dissection is not routinely performed because of high rate of surgery complications. Therefore, there is a need to find a good marker to ...

ea0032p1127 | Thyroid cancer | ECE2013

A case of papillary thyroid carcinoma in a patient with familial adenomatous polyposis of the colon

Zufiaurre Aitzol Lizarraga , Fano Miguel Paja , olano Aitziber Ugalde , Abasolo Estibaliz Ugarte , Iglesias Hernandez Natalia Covadonga

Thyroid carcinoma is a rare extraintestinal manifestation of colonic familial adenomatous polyposis (FAP). This syndrome is caused by germline mutations in adenomatous polyposis coli (APC) gene, on chromosome 5q21-q22. Many patients manifest various extracolonic features: upper gastrointestinal adenomas, congenital hypertrophic retinal pigment epithelial lesions, desmoids tumors, and thyroid, adrenal and brain cancers. It has been reported an incidence of 1.2% of thyroid carci...

ea0032p1128 | Thyroid cancer | ECE2013

Metastatic papillary thyroid carcinoma arising from thyroglossal duct cyst

Arslan Metin , Cerit Ethem Turgay , Iyidir Ozlem Turhan , Ozkan Cigdem , Degertekin Ceyla Konca , Kalan Isilay , Altinova Alev , Akturk Mujde , Toruner Fusun Balos , Ayvaz Goksun , Cakir Nuri , Taneri Ferit

The incidence of thyroid papillary carcinoma in thyroglossal duct cyst is <1%. Regional lymph node metastasis is usually seen in cases who have intrathyroidal tumor. We report a case of thyroid papillary carcinoma arising from thyroglossal duct cyst with lateral lymph node metastasis who have a normal thyroid gland and benign central compartment lymph nodes.Case report: A 38-year-old male patient was admitted with the complaint of swelling in the nec...

ea0032p1129 | Thyroid cancer | ECE2013

Thyroid cancer frequency in acromegalic subjects

Chentli Farida , Meskine Djamila , Daffeur Katia , Azzoug Said , Fedala Nora Soumeya

Introduction: It is now well demonstrated that thyroid disorders are more frequent in acromegaly than in normal population. Our aim is to analyze thyroid cancer frequency in a cohort of Algerian subjects with acromegaly.Material and methods: It is a retro and prospective study where 77 hyper somatotropic subjects were enrolled (34F and 43M) mean age=39ans (12–58). Mean GH rate=59 ng/ml (7–597, n<5). All had clinical examination, ro...

ea0032p1130 | Thyroid cancer | ECE2013

Poor prognosis of recurrent and persistent papillary thyroid carcinoma with high anti-thyroglobulin antibody titers

Kuo Sheng-Fong , Lin Jen-Der

Background: In patients with papillary thyroid cancer (PTC), serum thyroglobulin (Tg) levels are monitored in order to detect disease recurrence. However, these patients may show anti-thyroglobulin antibodies (TgAb) in serum, which may influence the quantitation of Tg level and thus the confirmation of disease recurrence. The aim of this retrospective study was to show clinical outcome and the diagnostic strategy of recurrent or persistent PTC patients with high serum TgAb tit...

ea0032p1131 | Thyroid cancer | ECE2013

Well differentiated thyroid-type carcinoma arising from struma ovarii a report of two cases

Barrera Jerome , Lina Lantion-Ang Frances , Quiwa Leslie

We report two rare cases of well differentiated thyroid-type carcinoma arising from struma ovarii managed in our institution.Case 1: A 41-year-old female admitted due to abdominal pain and vomiting. Her abdomen was globular with palpable vague mass on lower abdomen. Ultrasound scan revealed 12.5×12.1×8.3 cm heterogenous mass with ascites. Total abdominal hysterectomy with bilateral salphingo-oophorectomy was done and histopathology results reve...

ea0032p1132 | Thyroid cancer | ECE2013

Male patient with neck mass: ectopic cancer vs metastasic disease

Palermo Coromoto , Torres Oberto , Hernan Martinez Jose , Silva Frieda , Gutierrez Madeleine , Gonzalez Eva , de Lourdes Miranda Maria

Case of 33 years old male patient with an unremarkable past medical history, who after a car accident, a cystic nodular right neck mass was incidentally found by MRI of cervical spine. Physical examination revealed a mildly tender right neck mass. He was clinically and biochemically euthyroid. Denied history of neck irradiation. No family history of thyroid disease or thyroid cancer. Excisional biopsy of right neck mass showed metastasic well differentiated papillary carcinoma...

ea0032p1133 | Thyroid cancer | ECE2013

Papillary carcinoma with diffuse toxic guatr and highly resistant course

Ecemis Gulcin Cengiz , Saykili Selehattin , Salman Hacer , Bozlak Nurten

Introduction: The coexistence of hyperthyroidism and thyroid cancer is considered a rare event. We describe a case of papillary carcinoma of the thyroid that mimicked a diffuse toxic goiter.Case report: A 26-year-old female patient presented with a complaint of malaise was diagnosed to have thyrotoxicosis and following the tests performed (sT3: 7.7 (1.7–3.7 ng/dl), sT4: 2.5 (0.7–1.49 ng/dl) TSH: <0.0025 (0.35–4.94...

ea0032p1134 | Thyroid cancer | ECE2013

Brain metastases of papillary thyroid cancer: a case report and literature review

Ahmed-Ali Leila , Chentli Farida

Introduction: Papillary thyroid carcinoma is characterized by a good prognosis and a slow progression. Its metastases are usually located in cervical lymph nodes. But, sometimes they can reach the lung and bones. Cerebral metastases are exceptional as they have been reported in only 4%. Single or multiple, they can be totally symptomatic, but they are life threatening and require specific care as in the following caseCase report: A man aged 56, was refer...

ea0032p1135 | Thyroid cancer | ECE2013

Choroidal bilateral metastases from thyroid carcinoma: report of a case and review of the literature

Ahmed-Ali Leila , Amirou Lylia , Chentli Farida

Introduction: Metastases of thyroid carcinoma to the choroid and/or orbit are rare and usually occur at an advanced stage of the disease. The principal symptoms are decreased or blurred vision and/or persistent eye pain but they can be totally asymptomatic. They are diagnosed by ultrasound ocular CT and/or MRI scanning. The diagnosis is certain if they fix radioactive iodine. Their prognosis is very bad. Enucleation is the treatment of choice in cases of visual impairment. We ...

ea0032p1136 | Thyroid cancer | ECE2013

Thyroglobulin measurement in fine needle aspirates from cervical lymph nodes

Ribeiro Cristina , Paiva Sandra , Melo Miguel , Gouveia Sofia , Leitao Fatima , Carrilho Francisco

Introduction: Thyroglobulin (TG) measurement in fine needle aspirates cytology (FNAC) needle washout has become an important method for diagnostic of cervical lymph nodes, particularly in patients with differentiated thyroid cancers, but also in some patients before the diagnostic. We report some clinical cases to confirm its importance in these situations.Patients and methods: In our department we use this method since 2007. We report seven patients wit...

ea0032p1137 | Thyroid cancer | ECE2013

Poorly differentiated thyroid carcinoma: a clinicopathologic study of 30 cases

Hasbellaoui Fella , Meziani Nabila , Khalifa Anissa , Ziani Khadidja , Amokrane Samia , Zohra Benserai Fatma , Mechkour W , Boudissa M , Hadjarab S , Foudil D , Kesri N , Griene L , Afiane M , Amokrane L , Semrouni Mourad

Introduction: Poorly differentiated thyroid carcinoma are considered as a link between well differentiated carcinoma and undifferentiated ones. The histological definition is still controversial and various criteria have been proposed.Objective: The main objective of this study is to assess the management of poorly differentiated thyroid cancer in our department.Materials and methods: We reported 30 patients with poorly differentia...

ea0032p1138 | Thyroid cancer | ECE2013

Adrenal metastases from thyroid cancers

Bendali Mohammed , Boutekedjiret Faiza , Lylia Amirou Assila , Chentli Farida

Introduction: Adrenal metastases due to thyroid cancers deemed to very rare as adrenal glands are not a common site of metastases from thyroid cancer. When the phenomenon occurs the prognosis is very poor as adrenal metastases usually do not fix radioactive iodine. Our aim is to report three cases.Case reports: No. 1: a woman aged 57 harbouring anaplastic thyroid cancer classified T4, N1, M0, consulted for back pain, severe fatigue and skin pigmentation....

ea0032p1139 | Thyroid cancer | ECE2013

Thyroid papillary carcinoma in a toxic adenoma: case report

Martins Raquel G , Couto Joana , Santos Ana Paula , Matos Maria Joao , Capelo Rosa , Silva Jose Pedro , Lucena Ines , Cambao Mariana , Torres Isabel

Introduction: Malignant toxic thyroid nodules are rare, with few cases described in the literature. The prevalence of malignancy in toxic adenomas varies between 1 and 8% in different series (most, corresponding to <2.5%). For that reason, international guidelines recommend that they should not be submitted to fine needle aspiration biopsy.Case report: A 42-year-old female patient without relevant previous medical history was admitted to our hospital...

ea0032p1140 | Thyroid cancer | ECE2013

Ultrasonographic signs suggestive of malignancy in thyroid nodules

Molero Inmaculada Gonzalez , Vallejo-Mora Rosario , Dominguez-Lopez Marta , Romero Stella Gonzalez , Torres Francisca Garcia , de Adana Marisol Ruiz , Soriguer Federico

Introduction: Thyroid ultrasound is a widely used tool in monitoring thyroid nodule, allowing us to assess the size and other sonographic signs suspicious of malignancy, facilitating decisions about diagnosis and treatment.Objectives: To evaluate the presence of ultrasonographic signs suggestive of malignancy in patients with thyroid carcinoma in our hospital.Material and methods: Retrospective study of 63 patients with thyroid car...