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15th European Congress of Endocrinology

Poster Presentations

Thyroid (non-cancer)

ea0032p977 | Thyroid (non-cancer) | ECE2013

Determinants of between-subject variation in thyroid hormone status in healthy young men

Roef Greet , Taes Youri , Toye Kaatje , Verstraete Alain , Kaufman Jean-Marc

Background: Interindividual variation in thyroid hormone concentrations is greater than intraindividual variation, suggesting that individuals have different set-points for pituitary–thyroid axis function. Variation in thyroid hormone levels within the normal range has clinical effects and is associated with a number of clinical parameters such as bone mass, BMI, metabolic parameters, and heart rate. The aim of this study was therefore to gain a better insight into the de...

ea0032p978 | Thyroid (non-cancer) | ECE2013

Efficacy of treatment of cardiac complications in patients with Graves' disease

Leynova Elena , Tatyana Buydina

Purpose: To assess the dynamics of cardiac complications, the efficacy of angiotensin converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs) in patients with thyrotoxicosisMaterials and methods: Prospective 4 years study implicated 340 patients with thyrotoxicosis divided into three age groups: I, 80 patients below 40; II, 132 patients of 40–60; and III, 128 patients above 60. By the beginning of the study atrial fibrillation (A...

ea0032p979 | Thyroid (non-cancer) | ECE2013

Pilot study of nocturnal TSH surge in idiopathic short stature

Gadalla Fadila , Setouhi Maged , Sedik Salwa , Makboul Khaled , Sayed Rania EL , Guirgis Caroline

Background: TSH secretion shows a diurnal rhythm with a surge in the evening. The nocturnal surge is essential for thyroid function regulation. TSH surge is suggested to be blunted in central hypothyroidism. In idiopathic short stature (ISS), thyroid dysfunction has been suggested ranging from mild hypothyroidism to central hypothyroidism.Aim of the work: To study the pituitary thyroid axis and the TSH surge in ISS.Materials and me...

ea0032p980 | Thyroid (non-cancer) | ECE2013

Is previous hyperthyroidism associated with long-term cognitive dysfunction? A twin study

Lillevang-Johansen Mads , Petersen Inge , Christensen Kaare , Hegedus Laszlo , Brix Thomas

Introduction: Hyperthyroidism has been suggested to adversely affect cognitive function. However, this association could also be caused by genetic and environmental factors affecting both the development of hyperthyroidism and cognitive functioning. By investigating cognitive function within twin pairs discordant for hyperthyroidism, this potential confounding can be minimized. The aim of this study was to examine if hyperthyroidism is associated with long-term cognitive dysfu...

ea0032p981 | Thyroid (non-cancer) | ECE2013

The influence of single dose recombinant human thyroid-stimulating hormone on the efficacy of radioiodine therapy in patients with non toxic nodular goitre with low RAIU

Abdelrazek Saeid , Mysliwiec Janusz , Szumowski Piotr , Mojsak Malgorzata , Siewko katarzyna , Poplawska-Kita Anna

Aim: The aim of our study was to evaluate the influence of recombinant human thyroid-stimulating hormone (rhTSH) on the efficacy of radioiodine therapy in patients with non toxic nodular goitre with low RAIU.Materials and methods: The study was performed on 50 patients with non toxic nodular goitre (36 females and 14 males, aged 34–75 years) referred for radioiodine therapy. All patients had low RAIU (8–16%), 24 h after a diagnostic dose of I-1...

ea0032p982 | Thyroid (non-cancer) | ECE2013

PRIMARA: a prospective descriptive observational study to review cinacalcet use in patients with primary hyperparathyroidism in clinical practice

Schwartz Peter , Body Jean-Jacques , Cap Jan , Hofbauer Lorenz , Farouk Mourad , Gessl Alois , Kuhn Marc , Marcocci Claudio , Mattin Caroline , Munoz Torres Manuel , Payer Juraj , van de Ven Annenienke , Yavropoulou Maria , Selby Peter

PRIMARA is the first observational study to describe the demographic and clinical profiles of adults with primary hyperparathyroidism (pHPT) receiving cinacalcet in daily clinics across European countries.Patients with pHPT aged ≥18 years without prior cinacalcet treatment were eligible. Initial cinacalcet dosage and subsequent dose changes were at the investigator’s discretion. Information on dosing, biochemistry and adverse drug reactions (A...

ea0032p983 | Thyroid (non-cancer) | ECE2013

A comparative study evaluating the roles of inferior thyroid artery blood flow velocities measured by color flow Doppler ultrasonography, TSH receptor antibody and Tc-99m pertechnetate uptake for differential diagnosis between Graves' disease and silent thyroiditis

Shafi Zuhur Sayid , Ozel Alper , Demir Nazan , Kuzu Idris , Altuntas Yuksel

Objective: To compare the roles of inferior thyroid artery (ITA) peak systolic and end-diastolic velocities (PSV and EDV) measured by color flow Doppler ultrasonography (CFDUSG), TSH receptor antibody (TRAb) measured by M22 based ELISA and Tc-99m pertechnetate uptake for differential diagnosis between Graves’ disease (GD) and silent thyroiditis (ST).Methods: One hundred and fifty previously untreated subjects with GD (111 female, 39 male, mean age 3...

ea0032p984 | Thyroid (non-cancer) | ECE2013

Both Graves' disease and toxic nodular goiter are associated with increased mortality but differ with respect to the cause of death: a Danish population-based register study

Brandt Frans , Thvilum Marianne , Almind Dorthe , Christensen Kaare , Green Anders , Hegedus Laszlo , Heiberg Brix Thomas

Background: Hyperthyroidism has been associated with increased all-cause mortality. Whether the underlying cause of hyperthyroidism influences this association is unclear. Our hypothesis was that Graves’ disease (GD) and toxic nodular goiter (TNG) differ with respect to mortality risk and cause of death.Methods: An observational cohort study, using record-linkage data from nation-wide Danish health registers. 1.291 and 861 subjects with GD and TNG, ...

ea0032p985 | Thyroid (non-cancer) | ECE2013

Efficacy and safety of combined parenenteral and oral steroid therapy in Graves' orbitopathy

Beleslin Biljana , Ciric Jasmina , Zarkovic Milos , Knezevic Miroslav , Stojkovic Mirjana , Lalic Tijana , Nisic Tanja , Trbojevic Boza

Introduction: Glucocorticoids (GC) are the first line treatment for moderate-to-severe and active Graves’ orbitopathy (GO), but optimal treatment is still undefined. The aim of the present study was to analyze the efficacy and tolerability of combined parenteral GC pulse therapy followed by oral GC in the interpulse period.Methods: The study includes 50 patients (48±10 years; 37 females) with untreated, active and moderate-to-severe GO. Patient...

ea0032p986 | Thyroid (non-cancer) | ECE2013

Type and extent of morbidity before and after the diagnosis of hypothyroidism: a nationwide register-based study

Thvilum Marianne , Brandt Frans , Almind Dorthe , Christensen Kaare , Hegedus Laszlo , Heiberg Brix Thomas

Background: Hypothyroidism has been linked with an increased risk of morbidity such as cardiovascular disease and diabetes mellitus. However, it is unknown whether the burden of morbidity is present before or after the diagnosis of hypothyroidism.Aim: Evaluate the temporality and type of morbidity in hypothyroid patients.Methods: Observational cohort study. Based on record-linking between official Danish health registers 2822 subje...

ea0032p987 | Thyroid (non-cancer) | ECE2013

Influence of thyrotropin on human peripheral blood immune cell populations

Stasiolek Mariusz , Adamczewski Zbigniew , Pula Bartosz , Dziegiel Piotr , Lewinski Andrzej

Introduction: Dendritic cells (DCs) are considered as main regulators of immune system. Functional properties of DCs depend on their subtype, maturation status, interaction with other immune cells as well as environmental factors including hormones. Recently, we have shown a direct, independent of TSH, regulatory influence of thyroid hormones on human DCs function. The aim of the present study was to analyze ex vivo the effect of systemically administered TSH on human...

ea0032p988 | Thyroid (non-cancer) | ECE2013

Hemithyroidectomy for benign euthyroid goiter increases the mitochondrial membrane potential of peripheral mononuclear blood cells

Toft Kristensen Tina , Larsen Jacob , Lyngsie Pedersen Palle , Feldthusen Anne-Dorthe , Anthonsen Stine , Jelstrup Soren , Kvetny Jan

Introduction: Patients who do not develop overt hypothyroidism after hemithyroidectomy for benign euthyroid goiter have permanently increased serum levels of TSH and decreased levels of thyroid hormones within the reference ranges. Thyroid hormones are major regulators of mitochondrial function, and the mitochondrial membrane potential (MMP) can be measured by flow cytometry analysis of living cells as the fluorescence intensity of stained peripheral mononuclear blood cells (M...

ea0032p989 | Thyroid (non-cancer) | ECE2013

Influence of smoking on hyperthyroidism severity in newly diagnosed Graves' disease patients

Martin Sorina , Florea Suzana , Fica Simona

Introduction: Smoking is an independent risk factor for Graves’ disease (GD) and an independent predictor for Graves’ophtalmopathy (GO), but the influence on hyperthyroidism severity was not established.Aim: To evaluate the relationship between smoking and thyroid function at diagnosis and after administration of antithyroid drugs (ATDs) in GD patients.Materials and methods: We prospectively investigated 116 newly diagnos...

ea0032p990 | Thyroid (non-cancer) | ECE2013

Postprandial studies uncover differing effects on HDL particles of overt and subclinical hypothyroidism

McGowan Anne , M Widdowson William , O'Regan Anna , S Young Ian , Boran Gerard , McEneny Jane , Gibney James

Overt hypothyroidism (OH) and more controversially subclinical hypothyroidism (SCH) are associated with abnormal lipid metabolism and endothelial dysfunction under fasting conditions. Little data exists regarding the metabolic and vascular effects of OH or SCH under postprandial conditions.We aimed to characterize postprandial metabolism with emphasis on intestinally derived lipoproteins, HDL-cholesterol (HDL-C) and endothelial function in patients with ...

ea0032p991 | Thyroid (non-cancer) | ECE2013

Quantification of tissue T3 and T4 in rat and human heart by a novel HPLC-MS/MS method

Saba Alessandro , Colligiani Daria , Nannipieri Monica , Kusmic Claudia , Dos Remedios Cristobal , Simonides Warner , Iervasi Giorgio , Zucchi Riccardo

Thyroid hormone (T3) is mostly produced in peripheral tissues by thyroxine (T4) deiodination, and its functional effects are directly related to tissue concentration, which is quite difficult to assay by conventional immunological methods. We report a novel technique, based on tandem mass spectrometry (MS/MS) coupled to HPLC, which was used in left ventricular myocardium obtained from rat and human hearts.Samples were homogenized in...

ea0032p992 | Thyroid (non-cancer) | ECE2013

Study on linear growth and thyroid function for 12 years in patients with β thalassemia major

Soliman Ashraf , Al Yafei Fawzia , Al-Naimi Lolwa , Almarri Noora , Sabt Aml , Yassun Mohamed , Desanctis Vincenzo

Introduction: Short stature and hypothyroidism and are frequent complications of thalassemia major (TM).Patients and methods: We recorder growth parameters and investigated the thyroid function in TM patients attending our Pediatric Endocrine Clinics for 12 years. Definitions: overt hypothyroidism (low FT4 and increased TSH levels >5 μIU/ml); subclinical hypothyroidism (normal FT4, TSH between 5–10 μIU/ml) and cen...

ea0032p993 | Thyroid (non-cancer) | ECE2013

Levothyroxine requirements in thyroidectomized diabetic patients receiving metformin

Zafon Carles , Casteras Anna , Obiols Gabriel , Mesa Jordi

Background: Recent studies suggest that metformin (MF) may reduce TSH concentration. This fact could imply a dosage reduction of levothyroxine among those hypothyroid patients taking metformin.Aim: To determine, in a retrospective analysis, the impact of metformin in thyroidectomized patients (a condition not influenced by endogenous thyroid hormone production) on levothyroxine replacement.Patients and methods: One hundred ninety t...

ea0032p994 | Thyroid (non-cancer) | ECE2013

Association between the use of computed tomography scans using iodine-based contrast medium and the development of subsequent hyperthyroidism

Holmager Pernille , Thomsen Henrik , Faber Jens

Background and aim: There is an increasing use of computed tomography (CT) scans with an iodine-based contrast medium. Last year, a large University Hospital in Denmark performed 50 000 CT scans where each injection contained between 3500 and 7000 μg free iodine corresponding to 23–45 times normal daily intake. We wished to investigate if patients with newly diagnosed hyperthyroidism had been exposed to an iodine based CT scan within 1 year prior to symptoms of hyper...

ea0032p995 | Thyroid (non-cancer) | ECE2013

Metformin decreases thyroid volume and nodule size in subjects with insulin resistance

Gursoy Alptekin , Anil Cuneyd , Atesagaoglu Berna , Kut Altug , Nar Asli , Bascil Tutuncu Neslihan

Introduction: Previous reports have shown that subjects with insulin resistance have increased thyroid volume and nodule prevalence. We investigated the effects of metformin on thyroid volume and nodule size.Methods: This prospective data were gathered on newly diagnosed subjects with insulin resistance (n=100, 68 female, 32 male) between August 2008 and May 2010. Measurements of thyroid hormones and thyroid ultrasonography was performed in all ...

ea0032p996 | Thyroid (non-cancer) | ECE2013

A case of severe hypoglycaemia in a patient with hyperthyroidism

Patwari Pranjali , Narasimhan Anirudhan , Srinivasan Ramalingam

Introduction: Graves’ disease is a common condition which is usually treated with antithyroid drugs like carbimazole and propylthiouracil. Here we present a patient who developed severe hypoglycaemia after treatment with carbimazole for hyperthyroidism which is unusual in Indian population.Case report: A 31-year-old male Indian presented to Endocrine Clinic with typical signs and symptoms of thyrotoxicosis. His biochemistry showed FT3: 28...

ea0032p997 | Thyroid (non-cancer) | ECE2013

Associations between urinary phthalate metabolites and thyroid function: pilot study

Medic-Stojanoska Milica , Milic Natasa , Novakovic-Paro Jovanka , Bajkin Ivana , Icin Tijana , Milankov Andrijana , Popovic Djordje , Kovacev-Zavisic Branka , Curic Nikola

Background: Phthalates presents widespread endocrine disrupting chemicals in many personal-care and consumer products. A limited number of experimental and human studies suggest that exposure to phthalate may be associated with altered thyroid function, but a problem is not elucidated enough. This study focused to examination of the association between urine phthalate metabolites and thyroid function.Methods: We included 91 healthy person, 47 females and...

ea0032p998 | Thyroid (non-cancer) | ECE2013

Selective embolization of thyroid arteries (SETA) in patients with Graves' disease

Arzykulov Zhetkergen , Ormanov Bauyrzhan , Shaikhiyev Yerbol , Juraev Shakir , Shokebaev Adil , Aliev Arman

Introduction: Prevention of surgical complications in patients with severe forms of Graves’ disease is still not completely solved problem. The purpose of research was improve the results of surgical treatment of patients with severe Graves’ disease.Materials and methods: In 2012 introduced a method of treatment of patients with Graves’ disease SETA as a preoperative preparation. Presented results of surgical treatment of 30 patients, with...

ea0032p999 | Thyroid (non-cancer) | ECE2013

Short-term effects of thyroid hormone therapy on quality-of-life evaluation by ThyPRO questionnaire in chronic autoimmune thyroiditis

Sidoti Marilena , Giusti Massimo

In chronic autoimmune thyroiditis, increased TPOAb levels have been found to be associated with impaired quality-of-life (QoL). Aim of the study was to evaluate QoL by means of ThyPRO in women with positive TPOAb levels. From January to December 2011, 62 women were invited to the study. Inclusion criteria were: age >18 years, TPOAb >100 mIU/l, no previous therapy for thyroid, no current wish to become pregnant and availability of an E-mail address. Women were randomize...

ea0032p1000 | Thyroid (non-cancer) | ECE2013

Genetic examination of the TSHR gene in patients with congenital hypothyroidism: systematic survey of a Hungarian cohort

Labadi Arpad , Gellen Balazs , Ruzsa Beata , Rideg Orsolya , Kovacs Gabor L , Mezosi Emese , Persani Luca

Loss-of-function mutations in the TSH receptor (TSHR) gene are one of the most common known causes of congenital hypothyroidism (CH). While heterozygous mutations result in nonautoimmune isolated hyperthyrotropinemia, homozygous and compound heterozygous mutations may cause overt CH of various severity depending on the localization and type of the mutations.In our study we performed the systematic genetic analysis of the TSHR gene of a cohort of 85 Hunga...

ea0032p1001 | Thyroid (non-cancer) | ECE2013

In pregnant women receiving levothyroxine, higher 3rd trimester TSH and maternal underweight are associated with cesarean section due to foetal malposition

Minambres Inka , Aulinas Anna , Claramonte Marta , Martinez Sonia , Garcia-Patterson Apolonia , Maria Adelantado Juan , Corcoy Rosa

Context: In the background population, maternal TSH levels >2.5 mUI/l in late pregnancy have been reported to be associated with breech presentation. This has not been addressed in women treated with levothyroxine.Aim: Our aim was to study the relationship of 3rd trimester maternal TSH with caesarean section (CS) due to foetal malposition in pregnant women treated with levothyroxine since before pregnancy.Methods: We have studi...

ea0032p1002 | Thyroid (non-cancer) | ECE2013

Diagnosis of hypothyroidism is associated to an increased risk of acute decompensated heart failure occurrence, but not of mortality among heart failure outpatients

Triggiani Vincenzo , Iacoviello Massimo , Puzzovivo Agata , Antoncecchi Valeria , Angelo Giagulli Vito , Guastamacchia Edoardo , Favale Stefano

It has been demonstrated that hypothryoidism could affect the prognosis of patients with cardiovascular disease. The aim of this study was to better clarify the prognostic role of hypothyroidism in patients with chronic heart failure (CHF).We enrolled 384 consecutive outpatients (65±13 years, 296 males, NYHA 2.3±0.6, left ventricular ejection fraction, LVEF, 32±9%) with CHF (ESC criteria), in stable clinical conditions (at least 30 days) a...

ea0032p1003 | Thyroid (non-cancer) | ECE2013

Thyroid-stimulating hormone and insulin resistance indexes in women with polycystic ovary syndrome

Sumarac-Dumanovic Mirjana , Jeremic Danka , Stamenkovic-Pejkovic Danica , Milin Jelena , Cvijovic Goran , Micic Dragan

Thyroid dysfunction has been linked to reduced fertility. It is known that changes in SHBG and sex steroids are a consistent feature associated with hyper- and hypothyroidism. It is also has reported that women with polycystic ovary syndrome (PCOS) are more insulin-resistant than it would be expected on the basis of their age and BMI. The mechanisms underlying this phenomenon are still not clarified. Hyperandrogenaemia may play a role, but also other factors such as thyroid fu...

ea0032p1004 | Thyroid (non-cancer) | ECE2013

Overweight/obese women with primary acquired hypothyroidism in appropriate levothyroxine replacement therapy are characterized by impaired whole body energy metabolism

Martucci Federico , Manzoni Giuseppina , Lattuada Guido , Perseghin Gianluca

Introduction: Appropriately titrated levothyroxine (L-T4) replacement therapy may not be able to fully correct the entire set of metabolic defects afflicting individuals with primary hypothyroidism. Based on this hypothesis, the present study was undertaken to establish whether these patients have impaired whole body energy metabolism.Methods: We recruited 30 hypothyroid women with duration of the disease >2 years, BMI >...

ea0032p1005 | Thyroid (non-cancer) | ECE2013

TSH-deficiency is associated with a lower thyroid gland volume in hypopituitaric patients compared to healthy volunteers: a cross-sectional study

Santi Daniele , Brigante Giulia , Gnarini Valentina , Madeo Bruno , De Vincentis Sara , Carani Cesare , Faustini-Fustini Marco , Balestrieri Antonio , Rochira Vincenzo

Introduction: Thyroid volume (TV) depends on age, gender, anthropometry, smoking and iodine status. IGF1 plays a role on thyroid growth, as demonstrated in acromegaly and GH-deficiency. Finally, TSH is a well recognised permissive factor for thyroid tissue growth. The aim of the study is to evaluate the long-term effect of TSH-deficiency on TV in hypopituitaric patients compared with healthy volunteers.Methods: We performed a cross-sectional, controlled ...

ea0032p1006 | Thyroid (non-cancer) | ECE2013

Prevalance of GH deficiency in Turkish patients with Hashimoto's thyroiditis: a single center experience

Akin Safak , Aydin Kadriye , Gurlek Alper

Background and Aim: Prevalence of Hashimoto’s thyroiditis is increasing in Turkey. GH deficiency has been reported to associate with this disorder in several different ethnic population. The aim of this study was to evaluate GH deficiency in the population with Hashimoto’s thyroiditis.Materials and methods: Euthyroid Hashimoto’s thyroiditis patients, who admitted to the Department of Endocrinology and Metabolism of Hacettepe University, we...

ea0032p1007 | Thyroid (non-cancer) | ECE2013

Insulin resistance in patients with thyroid dysfunction and hepatosteatosis

Keskek Sakir Ozgur , Kirim Sinan , Kaya Ramazan , Tuzun Dilek , Ortoglu Gulay , Saler Tayyibe

Introduction: Hepatosteatosis is one of the results of insulin resistance. Thyroid dysfunctions effect on insulin sensitivity. The aim of this study was to evaluate insulin resistance in patients with hepatosteatosis and either hypothyroidism or hyperthyroidism.Design: A total of 407 patients with hepatosteatosis were included. These patients were further divided into two study subgroups and a control group: 102 subjects with hypothyroidism, 103 with hyp...

ea0032p1008 | Thyroid (non-cancer) | ECE2013

Vitamin D status in autoimmune hypothyroidism

Kota Sunil Kumar , Meher Lalit Kumar , Jammula Sruti , Modi Kirtikumar D

Objective: To investigate vitamin D status in patients with autoimmune hypothyroidism.Methods: The study group consisted of 100 patients with newly diagnosed Hashimato’s thyroiditis and 100 subjects as the control group. Parameters of calcium metabolism, thyroid function tests and 25(OH) vitamin D levels were measured.Results or case presentation: Mean age of the study groups was 33.4±4.8 years with female:male, 72:28. Vi...

ea0032p1009 | Thyroid (non-cancer) | ECE2013

Vascular endothelial growth factor and granulocyte–monocyte colony stimulating factor levels in nodular thyroid diseases

Bilgici Birsen , Ecemis Gulcin , Tuncel Ozgur , Bayrak Ilkay , Kan Elif , Atmaca Aysegul

Introduction: Vascular endothelial growth factor (VEGF) is a specific mitogen for endothelial cells. Granulocyte–monocyte colony stimulating factor (GM-CSF) is a key player in the regulation of steady-state functions. Studies have shown increased levels of VEGF and GM-CSF in benign and malignant tumors. The aim of this study was to evaluate the relation between VEGF and GM-CSF levels and thyroid nodules >1 cm. and negative for malignancy with fine needle aspiration bi...

ea0032p1010 | Thyroid (non-cancer) | ECE2013

Increased TRAb and/or low anti-TPO titers at diagnosis of Graves' disease (GD) are associated with an increased risk of developing ophthalmopathy after onset of GD

Lantz Mikael , Planck Tereza , Asman Peter , Hallengren Bengt

Objective: Patients with low thyroid peroxidase antibodies (anti-TPO) and increased TSH-receptor antibodies (TRAb) at diagnosis of Graves’ disease (GD) have been suggested to have an increased risk to develop Graves’ ophthalmopathy (GO). The aim was to evaluate if GO development can be predicted.Design: Observational study with registration of possible GD and GO risk factors.Methods: Three hundred and ninety nine patients...

ea0032p1011 | Thyroid (non-cancer) | ECE2013

Latent toxoplasmosis: a novel risk factor for autoimmune thyroid diseases in pregnancy?

Potlukova Eliska , Prochazkova Lucie , Jiskra Jan , Limanova Zdenka , Springer Drahomira , Calda Pavel , Flegr Jaroslav , Kankova Sarka

Introduction: Latent toxoplasmosis, a zoonosis caused by protozoan Toxoplasma gondii, is the most widespread human parasitosis in developed countries (prevalence 20–80%). Upon infection, T. gondii stays in human organism lifelong. It has been linked to several autoimmune diseases, including autoimmune thyroid disease (AITD). The aim of our study was to assess the impact of latent T. gondii infection on the prevalence of AITD in pregnancy with re...

ea0032p1012 | Thyroid (non-cancer) | ECE2013

Iodine status in women after early miscarriages in the Czech Republic

Jiskra Jan , Fait Tomas , Bilek Radovan , Bartakova Jana , Potlukova Eliska , Springer Drahomira , Telicka Zdenek , Limanova Zdenka

Background: Early miscarriages are of multifactorial origin. Subclinical thyroid dysfunction belongs to the common causes. Thyroid dysfunction in pregnancy is caused mainly by thyroid autoimmunity and/or iodine deficiency. The Czech Republic belongs to countries with sufficient iodine intake. The aim of the study was to determine iodine status in women after early miscarriages (n=183) and to compare it with randomly chosen age-comparable euthyroid women without previo...

ea0032p1013 | Thyroid (non-cancer) | ECE2013

An open-label, randomized, controlled study of the effectiveness and safety of a high intensity focused ultrasound device compared with observation in patients with non-malignant cold thyroid nodules

Leenhardt Laurence , Rouxel Agnes , Menegaux Fabrice , Esnault Olivier

Aim: To compare nodule volume change at 6 months follow-up in patients treated by ultrasound guided high intensity focused ultrasound (US-HIFU) with patients undergoing observation in a simple monocentric, open label, randomized-control study.Patients and methods: The study was IRB approved and all patients signed an informed consent. 32 patients with 34 benign cold thyroid nodules indicated for surgery were recruited for the study: 21 patients assigned ...

ea0032p1014 | Thyroid (non-cancer) | ECE2013

Biochemical testing on wide indication to detect overt hypothyroidism is justified: a population-based case–control study in patients newly diagnosed with overt autoimmune hypothyroidism

Carle Allan , Pedersen Inge Bulow , Knudsen Nils , Ovesen Lars , Rasmussen Lone Banke , Jorgensen Torben , Perrild Hans , Laurberg Peter

Objectives: Hypothyroid patients report a diversity of symptoms at disease presentation. We studied how useful symptoms are to predict hypothyroidism, and if this may vary between subgroups of patients.Methods: Patients newly diagnosed with overt autoimmune hypothyroidism (n=140) were prospectively identified in a population by linkage to diagnostic laboratory databases, and we concomitantly enrolled individually sex and age-region matched contr...

ea0032p1015 | Thyroid (non-cancer) | ECE2013

Associations of (F)T3 and the ratio FT3:FT4 with a cluster of obesity-related cardiovascular risk markers in healthy euthyroid middle-aged men and women

Roef Greet , Rietzschel Ernst , Van Daele Caroline , Taes Youri , De Buyzere Marc , Gillebert Thierry , Kaufman Jean-Marc

Background: We have previously shown that a higher BMI and less favorable body composition are associated with relatively higher FT3 levels (within the euthyroid range) in healthy young men. In this study, we aimed to investigate whether FT3 and the ratio FT3:FT4 are also associated with cardiovascular markers in a healthy euthyroid population of middle-aged men and women.Methods: Thyroid parameters were measur...

ea0032p1016 | Thyroid (non-cancer) | ECE2013

Evaluation of hemostatic parameters in patients with Hashimoto's thyroiditis

Gorar Suheyla , Bekdemir Handan , Candan Zehra , Culha Cavit , Alioglu Bulent , Aral Yalcin

Introduction: Thyroid dysfunctions and autoimmunity may concur in the pathogenesis of hemostasis abnormalities. Hashimoto’s thyroiditis (HT) is a frequently chronic autoimmune disease in thyroid gland. The aim of our study were to comparison the hemostatic parameters in patients with HT and control subjects.Method: A total of 52 women were evaluated. Age, TSH, free T3, free T4, anti M, anti Tg, TAFI, TFPI, PAI-1, tPA, PF-4, fib...

ea0032p1017 | Thyroid (non-cancer) | ECE2013

Comparison of hs-CRP and Fetuine-A levels before and after the treatment of subjects with subclinical hyperthyroidism

Calan Mehmet , Bilgir Oktay , Bilgir Ferda , Topcuoglu Tugba , Calan Ozlem

Background: This study was planned to reveal the effect of propylthiouracil treatment on CD40, hs-CRP and Fetuin-A levels of subjects with subclinical hyperthyroidism.Material and methods: After checking CD40, hs-CRP and Fetuin-A levels of 35 patients with subclinical hyperthyroidism, they were given 50 mg of propylthiouracil tablet (thrice daily). After the 3-month administration, CD40, hs-CRP and Fetuin-A levels were then compared to the levels before ...

ea0032p1018 | Thyroid (non-cancer) | ECE2013

Thyroid morphofunctional parameters in amiodarone induced thyrotoxicosis compared to endogenous hyperthyroidism

Balas Melania , Amzar Daniela , Golu Ioana , Gurban Camelia , Stana Loredana , Zosin Ioana

Introduction: In the interpretation of the thyroid tests in a patient treated chronically with amiodarone (AMD), the effects on the thyroid should be considered. The aim of the study was to evaluate the thyroid parameters in amiodarone-induced thyrotoxicosis (AIT), compared to endogenous hyperthyroidism.Materials and methods: The study group included 36 patients with AIT (mean age 57.6±7.8 years, 11 women (F), 25 men (M)). The mean duration of AMD-t...

ea0032p1019 | Thyroid (non-cancer) | ECE2013

Differential item functioning of the thyroid-specific quality of life questionnaire ThyPRO

Watt Torquil , Hegedus Laszlo , Bonnema Steen Joop , Bjorner Jakob Bue , Groenvold Mogens , Rasmussen Ase Krogh , Feldt-Rasmussen Ulla

Objective: Thyroid diseases have been shown to affect quality of life. A thyroid-specific patient-reported outcome (PRO) measuring quality of life, the ThyPRO, has recently been developed and validated using classical clinic- and psycho-metric methods. The purpose of the present study was to apply modern psychometrics to validate the measure as the extent of differential item functioning (DIF) according to sex, age, education and diagnosis, within the ThyPRO.<p class="abst...

ea0032p1020 | Thyroid (non-cancer) | ECE2013

Insulin resistance in patients with hypothyroidism or hyperthyroidism without hepatosteatosis

Keskek Sakir Ozgur , Kirim Sinan , Tasdemir Mehmet , Tuzun Dilek , Ortoglu Gulay , Saler Tayyibe

Introduction: Insulin resistance, refers to decreased response of tissues to insulin, primarily associated with type 2 diabetes and glucose intolerance. Several results were obtained in previous studies about the relation between insulin resistance and thyroid dysfunction. In these studies hepatosteatosis was not an exclusion criteria despite insulin resistance has a key role in the development of it. In this study we aimed to investigate insulin resistance in patients with hy...

ea0032p1021 | Thyroid (non-cancer) | ECE2013

Should subclinical hypothyroidism diagnosed during pregnancy be treated with long-term L-thyroxine?

Vaidya Bijay , Knight Bea , Hill Anita , Hattersley Andrew , Shields Beverley

Background: Subclinical hypothyroidism is common in pregnancy affecting about 5% of all pregnant women, and is associated with adverse pregnancy outcomes. There is a general consensus that subclinical hypothyroidism detected during pregnancy should be treated with L-thyroxine (Stagnaro-green et al. 2011, DeGroot et al. 2012). However, it is unclear whether the treatment should be limited only during the pregnancy or continued long-term. Therefo...

ea0032p1022 | Thyroid (non-cancer) | ECE2013

IgG4-related Hashimoto's thyroiditis: an emerging variant of a well known disease

Luiz Henrique , Goncalves Diogo , Pereira Bernardo , da Silva Tiago , Veloza Andreia , Matos Catarina , Manita Isabel , Cordeiro Maria , Raimundo Luisa , Oliveira Ana , Brito Maria , Portugal Jorge

Introduction: IgG4-related Hashimoto’s thyroiditis (HT) is a very recently reported entity, characterized by thyroid inflammation rich in IgG4-positive plasma cells associated with marked fibrosis. It may be part of the systemic IgG4-related sclerosing disease and is associated with younger age, lower female:male ratio, higher levels of thyroid autoantibodies, low echogenicity on ultrasound (US), rapid progress requiring surgery and more subclinical hypothyroidism, when c...

ea0032p1023 | Thyroid (non-cancer) | ECE2013

Prevalence of thyroiditis in ankylosing spondylitis patients

Bayram Korhan Baris , Harman Ece , Akcay Serkan , Bal Serpil , Arslan Banu

Objective: We aimed to evaluate the prevalance of thyroiditis in ankylosing spondylitis patients in this study. We investigated the role of serum procalcitonin as a chronic inflamatory marker in ankylosing spondylitis.Methods: Sixty-seven patients who diagnosed as ankylosing spondylitis according to American College of Rheumatology (ACR) criteria and 57 healthy controls were included in our study. Serum levels of procalcitonin, TSH, free triiodothyronine...

ea0032p1024 | Thyroid (non-cancer) | ECE2013

The study of gastrointestinal hormones in patients with hypothyroidism of middle-aged and elderly

Moldabek Gulnar , Abylayuly Zhangentkhan , Mansharipova Alma

The purpose of study was to examine the content of gastrointestinal hormones in patients with hypothyroidism.Objectives and methods: We investigated of 37 patients, which hypothyroidism, at the age from 23 to 65 years. The diagnosis of hypothyroidism was confirmed by measurement of thyroid hormones and TSH in serum. Immunohistochemistry in gastrobiopsies of the antrum of patients studied gastrin, serotonin, melatonin. The primary antibodies used commerci...

ea0032p1025 | Thyroid (non-cancer) | ECE2013

The study of levels erythropoietin and proinflammatory cytokines in patients with hypothyroidism of different ages

Moldabek Gulnar

Objectives: The aim of study was to examine the levels erythropoietin in hypothyroidism with anemic syndrome of different ages.Methods: We investigated 52 patients with hypothyroidism with irondeficiency normochromic and hypochromic anemia. Among them were 21 patients between ages from 21 to till 45 years old and 31 over 45 years of age. Examination included total blood, in the blood levels of thyroid hormones, serum iron, erythropoietin, ferritin by sta...

ea0032p1026 | Thyroid (non-cancer) | ECE2013

Acute renal failure as the first presentation of severe hypothyroidism

Anil Cuneyd , Oruc Aysegul

Introduction: Renal impairment associated with hypothyroidism without any other clear underlying cause is relatively rare. We report a case with severe hypothyroidism admitted with acute renal failure.Case report: A 72 years old female patient was addmitted to the emergency department with progressively worsening complaints of fatigue, somnolence, and swellings all over her body for the last 3 weeks. Initial laboratory examination revealed acute renal fa...

ea0032p1027 | Thyroid (non-cancer) | ECE2013

Thyroid diffuse lipomatosis: a rare and benign disease

Lau Eva , Freitas Paula , Goncalves Frederica , Pardal Joana , Eloy Catarina , Matos-Lima Luis , Carvalho Davide

Introduction: Diffuse lipomatosis of the thyroid is a very rare disease, characterized by extensive infiltration of thyroid parenchyma by mature adipose tissue. It is not accompanied by accumulation of amyloid fibrils.Clinical report: Male, 47 years old, followed in Endocrinology by hypothyroidism, since 13 years old, medicated with levothyroxine, with unremarkable growth and pshicomotor development. In 2002, thyroid echography showed a solid and heterog...

ea0032p1028 | Thyroid (non-cancer) | ECE2013

Regression of ophthalmopathic exophthalmos in Graves' disease after thyroidectomy: an observational study in a surgical series

Bhargav Panchangam Ramakanth

Background: Ophthalmopathic exophthalmos is reported to favourably regress after total thyroidectomy compared to radio-iodine or antithyroid drug therapy. In this context, we present our experience based on a surgical series of Graves’ disease.Materials and methods: This is a prospective study of 15 patients of Graves’ disease associated with ophthalmopathic exophthalmos. Preoperative and monthly postoperative evaluation of exophthalmos was don...

ea0032p1029 | Thyroid (non-cancer) | ECE2013

Vitamin E supplementation in the treatment of Graves' disease

Petrulea Mirela Sanda , Ilie Ioana , Valea Ana , Ghervan Cristina , Georgescu Carmen , Login Cezar , Muresan Adriana , Duncea Ileana

Hyperthyroidism in the course of Graves’ disease leads to intensification of oxidative processes resulting in increased oxidative stress.Objectives: The effect of supplementation with vitamin E was monitored on the speed of attaining euthyroidism and on the oxidative stress parameters in patients with Graves’ disease, treated with thiamazole.Patients and methods: We examined 43 hyperthyroid patients and 12 euthyroid healt...

ea0032p1030 | Thyroid (non-cancer) | ECE2013

Radioiodine treatment of hyperthyroidism in the elderly

Azevedo Teresa , Martins Teresa , Neto Joao , Oliveira Sofia , Rovira Eugenia , Rodrigues Fernando

Introduction: Treatment of hyperthyroidism in older adults is crucial to reduce its morbidity and mortality. Radioactive iodine has been widely used in this age group due to its efficacy, safety and cost-effectiveness.Aim: To determine the efficacy of 131I for treatment of hyperthyroidism in the elderly.Methods: Retrospective study of 86 hyperthyroid patients aged ≥65 years who performed radioiodine therapy. We eva...

ea0032p1031 | Thyroid (non-cancer) | ECE2013

The influence of subclinical hypothyroidism on glucose levels

Radinovic Vesna Popovic , Milutinovic Zorica Rasic , Jevtic Jelena Tica , Vujovic Marina , Gluvic Zoran , lackovic Milena , Ilic Maja Stojadinov

Background: Recently many authors are questioning the existing of elements of metabolic syndrome (MetSy) in patients with subclinical hypothyroidism (SH). In this cross sectional study we observed glycemia, as an element of MetSy, in newly diagnosed patients with SH.Materials and methods: Seventy females participated in study. Among them there were 50 patients with SH, mean age 58.3 (±8.53), and 20 controls without SH, mean age 51.1 (±6.79). We...

ea0032p1032 | Thyroid (non-cancer) | ECE2013

Coexistent toxic adenoma and Riedel thyroiditis: a case report

Tam Abbas Ali , Ozdemir Didem , Ersoy Pamir Eren , Kilicarslan Aydan , Ersoy Reyhan , Cakir Bekir

Riedel thyroiditis is a rare chronic inflammatory disease of the thyroid. It is characterized by replacement of normal parenchyma with dense fibrotic tissue. Peripheral tissues might also be affected and this may cause airway obstruction, dysphagia, recurrent laryngeal nerve palsy and hypoparathyroidism. We report a patient with toxic adenoma previously treated with radioactive iodine and histopathologically confirmed Riedel thyroiditis.Case: A 61 years ...

ea0032p1033 | Thyroid (non-cancer) | ECE2013

Internal jugular vein thrombosis and intensely hypermetabolic thyroid on 18F-FDG PET/CT

Boscolo Marina , Corvilain Bernard

Internal jugular vein thrombosis (IJVT) is generally related to central venous access devices (CVADs) because of endothelial trauma or inflammation. Other reported causes include neck surgery complication, malignancies, deep neck infections, intravenous drug abuse, ovarian hyperstimulation syndrome and hypercoagulable states.We report the case of a 47-year-old woman presenting with acute neck pain, local swelling and fever. Neck ultrasound with Doppler s...

ea0032p1034 | Thyroid (non-cancer) | ECE2013

Comparison of pre- and post-levothyroxine hs-CRP and fetuin-A levels in subclinical hypothyroidism

Calan Mehmet , Bilgir Oktay , Bilgir Ferda , Calan Ozlem , Cinali Turker

Background: The objective of this trial is to determine pre- and post-levothyroxine treatment levels of inflammation markers, high sensitive-C reactive protein (hs-CRP) and fetuin A in cases with subclinical hypothyroidism.Material and methods: A total of 32 patients with a diagnosis of subclinical hypothyroidism and a control group of 30 healthy individuals were tested for hs-CRP ile fetuin A levels, followed by administration of 50 μg levothyroxin...

ea0032p1035 | Thyroid (non-cancer) | ECE2013

The natural history of subclinical hyperthyroidism: a single centre experience

Anagnostis Panagiotis , Efstathiadou Zoe , Zouli Chrisanthi , Soukia Albana , Panagiotou Athanasios , Karathanasi Eleni , Kita Marina

Introduction: The possibility of progression of subclinical hyperthyroidism (SH) to overt hyperthyroidism (OH) is a critical point in deciding whether to treat this situation.The aim of this study is to evaluate the rate of progression of SH to OH and the factors influencing this outcome.Methods/design: This is a retrospective study at an endocrine referral service in Northern Greece. Data from patients with SH diagnosed between 19...

ea0032p1036 | Thyroid (non-cancer) | ECE2013

Morpho-functional features of rabbit's thyroid gland with its autotransplantation in the thigh muscle

Makarov Igor V , Fedorina Tatyana A , Volova Larisa T , Bodrova Anastasia V

The aim of our study was to determine the possibility of engraftment and function of the native thyroid tissue in its autotransplantation in the thigh muscle in rabbits. The experiment included 10 animals species Chinchilla Breed at the age of 12–18 months – five females and five males. In order to simulate the animals primary postoperative hypothyroidism animal extrafascial thyroidectomy was performed, and then on the inside of the left thigh of the neurovascular bu...

ea0032p1037 | Thyroid (non-cancer) | ECE2013

Sexual dysfunction in women with thyroid pathology

Ana Valea , Cristina Ghervan , Alina Silaghi , Iulia Iacob , Florica Tomesc , Adina Terec , Ileana Duncea

Introduction: Sexual dysfunction is a particular pathology with relative high prevalence, often underestimated in general population. It’s manifest as an impairment of sexual desire, orgasm, sexual excitement or pain related to intercourse. Although often recognize a psychogenic cause, sexual dysfunction are found also in various systemic diseases more or less related to changes of sexual hormones. Thyroid pathology, particularly hyper and hypothyroidism, with high freque...

ea0032p1038 | Thyroid (non-cancer) | ECE2013

Relationship of benign thyroid disorders with histological alterations of breast tissue. (Preliminary results of an observational study conducted in Greece)

Angelousi Anna , Zapanti Evangelia , Prokopiou Maria , Kouraklis Grigorios , Kontzoglou Konstantinos

Introduction: The association of thyroid disorders including autoimmune thyroiditis with the risk for breast cancer is controversial (1–4). A recent study found that triidothyronine (T3) levels are positively associated with breast cancer specific mortality (5). Experimental studies have shown that T3 mimics the effects of estrogen in human breast cell lines and induces the expression of progesterone receptors (6).Purpose: The ...

ea0032p1039 | Thyroid (non-cancer) | ECE2013

Clinical outcomes in Graves' disease after therapy with anti-thyroid drugs, surgery, or radioiodine

Aribi Yamina , Ould kablia Samia , Brakni Lila , Hadjres Lamia , Koli Meriem , Abderahmane Samir Ait , Bentayeb Fateh , Sellal Zoubir , Bensaleh Meriem , Kemali Zahra , Khodja Reda Nacer , Medjaher Meriem , Haffaf E M

The most common cause of hyperthyroidism in young patients is Graves’ disease (GD). It is an auto immune disorder caused by TSH-receptor-stimulating auto antibodies.Treatment options for GD include anti-thyroid drugs (ATD), radioactive iodine (RAI), and surgery. The treatment modalities used vary in different parts of the world.Objectives: To compare the effect of different treatment and to determine the profile of patients wh...

ea0032p1040 | Thyroid (non-cancer) | ECE2013

Thyroid hormone elevates IL6 tissues content and causes hypoleptinemia

Biz Carolina , Oyama Lila Missae , Telles Monica Marques , do Nascimento Claudia Oller

Oxidative stress is regarded as a pathogenic factor in hyperthyroidism. IL6 has been described as acting as a protective intrahepatocellular against oxidative stress and mitochondrial dysfunction. On the opposite way leptin has been shown to increase oxidative stress. The impact of thyroid hormones on circulating cytokines levels has been demonstrated with conflicting results both in human and rats. Most of the studies concerned hyperthyroidism showed increased levels of IL6 c...

ea0032p1041 | Thyroid (non-cancer) | ECE2013

The determination of nitric oxide levels in treatment-naïve hypothyroid females: pilot study

Gluvic Zoran , Jevtic Jelena Tica , Rasic-Milutinovic Zorica , Popovic-Radinovic Vesna , Vujovic Marina , Lackovic Milena , Resanovic Ivana , Isenovic Esma R , Popin-Taric Marija , Vasic-Vlaisavljevic Anita , Paunovic Nevena

Background: Hypothyrosis is an atherosclerosis-promoted condition. On the other hand, nitric oxide (NO) has antiatherogenic cardioprotective properties. By some Doppler ultrasound parameters (intima-media complex thickness (IMCT) and systolic velocity (SV)), one can point out the level of atherosclerosis presence in cardiovascular system out of histopathology.We primarily determine NO levels in studied population and then examine their influence on menti...

ea0032p1042 | Thyroid (non-cancer) | ECE2013

Haemodialysis-induced changes in thyroid hormones and thyrotropin

Horacek Jiri , Sulkova Sylvie Dusilova , Malirova Eva , Dlabalova Blanka , Safranek Roman , Kubisova Michaela , Kalousova Marta , Maly Jaroslav , Zak Pavel

Introduction: In end-stage renal disease (ESRD), thyroid function tests are often abnormal, and their interpretation is not always straightforward. While haemodialysis (HD) procedure has well-established profound effects on the serum levels of a variety of molecules no such data have been published on thyroid hormones.Methods: In 110 ESRD patients, total and free thyroxine (T4 and fT4), total and free triiodothyronine (T3...

ea0032p1043 | Thyroid (non-cancer) | ECE2013

Simultaneous occurrence of hyperthyroid and hyperglycemic emergency in a middle aged woman

Armeni Eleni , Karlis George

Introduction: Thyroid storm is a rare condition, reflecting an extreme physiological state within the spectrum of thyrotoxicosis. The disorder consists of the clinical manifestations of thyrotoxicosis in association with altered mental status. On the other hand, excess circulating thyroid hormones are associated with glycemic disorders, like hyperglycemia and insulinopenia. Moreover, diabetic ketoacidosis has been associated with thyroid storm in few cases. We report the case ...

ea0032p1044 | Thyroid (non-cancer) | ECE2013

Immune associations in chronic thyroiditis: December 2012

Poiana Catalina , Carsote Mara , Staicu Daniela Cristina , Clodeanu Alexandrina , Peretianu Dan

Objectives: To investigate how the immune associations (IA) may have significance for diagnosis or therapy in thyroiditis.Material and method: i) Patients: A. ‘Classical’ Hashimoto thyroiditis (hyper-ATPO-emia, HT)=1196, B. thyroiditis with isolated hyper-ATG-emia, with normal ATPO (T-ATG)=73, C. thyroiditis ‘sero-negative’ (normal ATPO and ATG, pathology diagnosis)=8, D. idiopathic myxedema (hypothyroidism, no A,B,C)=69; E. control=1...

ea0032p1045 | Thyroid (non-cancer) | ECE2013

Graves' disease and cardiovascular risk factors

Brandao Carla , Neves Celestino , Palmares Carmo , Sokhatska Oksana , Esteves Cesar , Dias Camila , Pereira Miguel , Delgado Luis , Carvalho Davide , Medina Jose Luis

Objective: To evaluate the interrelationships between Graves’ disease (GD) and cardiovascular risk factors.Subjects and methods: We analyzed thyroid function tests, anti-thyroid antibodies, BMI, insulin resistance markers, namely homeostasis model assessment for insulin resistance (HOMA-IR and HOMA-B), the quantitative insulin sensitivity check index (QUICKI), hepatic insulin sensitivity index (HISI), whole-body insulin sensitivity index (WBISI), in...

ea0032p1046 | Thyroid (non-cancer) | ECE2013

Thyroid dysfunction in type 2 diabetic patients

Diaz-Benito Jose

Introduction: While there is no consensus about population screening for hypothyroidism there is compelling evidence to support case-finding for hypothyroidism in those with autoinmune disease, such as type 1 diabetic patients. The present study has been made to estimate the prevalence of thyroid dysfunction in type 2 diabetic patients. In the British Whickham survey 9.3% of women and 1.2% of men had serum TSH values over 10 μIU/ml. The Colorado thyroid disease prevalence...

ea0032p1047 | Thyroid (non-cancer) | ECE2013

Clinical and subclinical hypothyroidism and their relation to cardiovascular risk factors

Golu Ioana , Vlad Mihaela , Cornianu Marioara , Amzar Dana , Tudoran Cristina

The cardiovascular system (CVS) is one of the major targets of thyroid hormone action.The thyroid function has a direct effect on heart rate, cardiac output and systemic vascular resistance.The prevalence of hypothyroidism in the general population is high, particularly in females (9–15%). Overt hypothyroidism is associated with severe cardiovascular manifestations including reduced intravascular volume, increased systemic vas...

ea0032p1048 | Thyroid (non-cancer) | ECE2013

The usefulness of thyroid function test in patients presenting with symptomatic bradycardia/complete heart block

Mlawa Gideon , Silveira Maria

Background: The causes of symptomatic bradycardia/complete are multifactorial. Bradycardia/complete heart block may be drug induced, electrolyte imbalance, ischaemic heart disease, or thyroid dysfunction. Hypothyroidism and electrolyte disturbances are reversible.Objectives/aims: To dentify/find out whether thyroid function test where performed in patients presenting with bradycardia/CHB in keeping with good practice before insertion of permanent pace ma...

ea0032p1049 | Thyroid (non-cancer) | ECE2013

Subacute thyroiditis: unusual presentation and diagnostic troubles

Paragliola Rosa Maria , Ricciato Maria Pia , Di Donna Vincenzo , Castellino Laura , Lovicu Rosa Maria , Pontecorvi Alfredo , Corsello Salvatore Maria

A 73 years old man came to our observation for severe dysphagia and loss of weight (10 kg in 1 month). About 30 years before he had myocardial infarction and he underwent coronary artery bypass graft. One week before the first medical evaluation, patient suspended all drugs per os because he could not swallow pills and food. Thyroid function test revealed a severe hyperthyroidism (FT3 11.9 pg/ml; FT4 40 pg/ml; TSH <0.01 μU/ml). Anti-TSH ...

ea0032p1050 | Thyroid (non-cancer) | ECE2013

Simplified approach for the treatment of post-thyroidectomy hypocalcemia: a Pilot study

Bhargav Panchangam Ramakanth

Introduction: One of the notable morbidity after total thyroidectomy is hypocalcemia related symptoms. Various treatments ranging from oral to parenteral calcium have been advocated. In this context, we analysed the benefits of bolus calcium vis-à-vis infusions for symptomatic post-thyroidectomy hypocalcemia.Patient and methods: The study was conducted in Endocrine Surgery Department in a teritiary care hospital. All the patients with benign thyroid...

ea0032p1051 | Thyroid (non-cancer) | ECE2013

The influence of thyroid hormones on the variability of blood pressure

Nisic Tanja , Stojanovic Milos , Stojkovic Mirjana , Beleslin Biljana , Ciric Jasmina , Lalic Tijana , Trbovic Bozo , Zarkovic Milos

Introduction: Changes in thyroid function have significant impact on the cardiovascular system.Methods: In a group of 37 subjects the level of thyroid hormones FT4, FT3, and TSH were measured. Then carried out short-term analysis for 30 min measureing variability of blood pressure with non-invasive TASK FORCE monitor. Registered data were analyzed by spectral analysis of variability. Statistical analysis were done by Pearson correla...

ea0032p1052 | Thyroid (non-cancer) | ECE2013

Serum concentrations of cholesterol and triglyceride in patients with type 2 diabetes and incident hypothyroidism

Diez Juan J , Iglesias Pedro

Background: Subclinical thyroid hypofunction and elevation of serum lipid concentrations are two factors that may act synergistically in the increase of cardiovascular risk in patients with type 2 diabetes. However, the association between subclinical hypothyroidism and dyslipidemia is a matter of debate.Objective: Our aim has been to assess whether incident hypothyroidism detected in a screening program is accompanied by elevations in the serum concentr...

ea0032p1053 | Thyroid (non-cancer) | ECE2013

The characteristics of thyroid pathology in patients with parathyroid adenoma

Sarac Fulden , Savas Sumru , Akcicek Fehmi

Introduction: Thyroid and parathyroid pathology may coexist; classically, this is described in multiple endocrine neoplasia. Other nonsyndromic scenarios result in pathologies of these endocrine organs coexisting. The aim of the investigation the chracteristics of thyroid pathology in patients with parathyroid adenoma.Subjects and method: The study population included 42 (26 patients age <60 years vs 16 patients age ≥60 years) patients with par...

ea0032p1054 | Thyroid (non-cancer) | ECE2013

Learning and development of thyroid FNA in a endocrine clinic

Lorenzo Jaime , Ruth Boente , Yosu Anton , Sas Manuel

Background: Development of thyroid ultrasound and FNA is more frecuent to make it in a endocrine clinic, that means to make more diagnosis medical process and so to avoid more outpatients visits. But it’s neccesary a specific treaning. We tried to evaluated our treaning.Material and methods: After specific treating in radiologic department, we have compared our results in two consecutive periods. The first one in the first year after treaning develo...

ea0032p1055 | Thyroid (non-cancer) | ECE2013

Does a normal thyroid ultrasound image always accompany normal thyroid functions test results?

Tam Abbas Ali , Kaya Cafer , Ucler Rifki , Dirikoc Ahmet , Ersoy Reyhan , Cakir Bekir

Introduction: Nowadays, ultrasonography (USG) is being used very commonly and indispensably for diagnosing thyroid diseases. Heterogeneous appearance of thyroid parenchyma is associated with positivity for thyroid autoantibody and hypofunctioning of thyroid gland. On the other hand, it is not determined whether thyroid parenchyma appearing totally of normal ecogenity on USG is related to presence normal thyroid function tests or otherwise. The objective of our study was evalua...

ea0032p1056 | Thyroid (non-cancer) | ECE2013

The cholesterol and Lp(a) levels in Hashimato's thyroiditis

Yetkin Demet Ozgil , Dogantekin Betul

Objective: The risk of atherosclerotic heart disease is increased in hypothyroidism. Although the reason is not clear. It is known that high level of Lp(a) is increases the risk of atherosclerotic heart diseases. The aim of this study is to investigate the relation between Lp(a) levels and thyroid hormones in the Hashimato’s patients.Methods: One hundred and fifty Hashimato’s patient (50 patients diagnosed with clinic hypothryoid, 50 patients d...

ea0032p1057 | Thyroid (non-cancer) | ECE2013

Comprehensive assessment of thyroid gland structure and function in men with metabolic syndrome

Tsygankova Oksana , Anufrienko Elena , Platonov Dmitry , Ekimova Julia , Ruyatkina Lyudmila

Introduction: The aim of study was to perform a comprehensive structural and functional assessment of thyroid gland in men with metabolic syndrome (MS).Methods: Main group (MG) of 116 men aged 35–60 years with MS (by International Diabetes Federation definition) and 34 healthy controls of the same age profile underwent a comprehensive examination of thyroid gland which included physical assessment, full serum thyroid hormonal profile – total an...

ea0032p1058 | Thyroid (non-cancer) | ECE2013

Empirical calcium supplements paves way for day surgery complete thyroidectomy

Lo Xina , Tam Tsz Kim , Leong Heng Tat

Post operative hypocalcemia poses significant resistance to early discharge of total thyroidectomised patients. Our institute implemented a new protocol to give empirical calcium and vitamin D supplements since Jan 2012 to prevent symptomatic hypocalcemia and facilitate early discharge. 75 (88.24%) out of 85 eligible cases did not have significant or symptomatic hypocalcemia and can be discharged by within 1 day with only two (2.67%) patients being readmitted electively for si...

ea0032p1059 | Thyroid (non-cancer) | ECE2013

Is TSH suppression an efficient thyroid nodular goitre therapy?

Drbalova Karolina , Vodak Miroslav , Nyvltova Monika , Tuckova Inna , Hill Martin

Levothyroxine suppression therapy, i.e. keeping the TSH value below 0.3 mIU/l with the aim to reduce the total thyroidal tissue or nodule volume, is an arguable and controversial issue not only due to the effect upon nodule volume but also because of the extent of necessary suppression, the effect of incomplete suppression, long-time therapeutic effects and risk of cardiovascular problems and osteoporosis.The incidence of nodular alterations rises with a...

ea0032p1060 | Thyroid (non-cancer) | ECE2013

Correlation between untreated subclinical hypothyroidism, nephropathy and cardiovascular diseases in type 2 diabetic patients

Themeli Yllka , Bajrami Valbona , Muka Lutfie , Barbullushi Myftar , Idrizi Alma , Teferici Daniela , Daka Albana

Aim: The aim of this study was to determine the relationship between subclinical hypothyroidism and prevalence of nephropathy and cardiovascular disease in type 2 diabetic patients without taking thyroid medication.Methods: Serum thyrotropin and free thyroxine concentrations were measured in 50 type 2 diabetic subjects in DC ‘Ikeda-Euromedica’ and DC ‘’ in Tirana, from September 2009 until September 2012. In a cross-sectional st...

ea0032p1061 | Thyroid (non-cancer) | ECE2013

Relationships between antithyroperoxydase antibody levels, thyroid function and echographic patterns in chronic thyroiditis: December 2012

Carsote Mara , Poiana Catalina , Staicu DanielaCristina , Clodeanu Alexandrina , Peretianu Dan

Aim/objectives: To investigate relationships between thyroid function, antithyroperoxydase antibodies (ATPO), antithyroglobuline antibodies (ATG) and correlations with echographic pattern in Hashimoto thyroiditis and related diseases.Materials and methods: Diagnosis: i) ATPO >34 μ/ml=Hashimoto thyroiditis (HT); ii) ATPO=normal with high ATG=thyroiditis with only hyper-ATG (T-ATG). Thyroid function: TSH. Echographic patterns=10 (Peretianu, this C...

ea0032p1062 | Thyroid (non-cancer) | ECE2013

Ten ultrasonographic thyroid pattern in Hashimoto's thyroiditis: re-evaluation after 12 years

Peretianu Dan , Poiana Catalina , Carsote Mara , Cristina Staicu Daniela , Clodeanu Alexandrina

Aim: To re-analyze the concept of echographic thyroid patterns (ETP) and clinical diagnostic in thyroidology, proposed 12 years ago.Materials and methods: i) Between 1996 and 2012, >25 000 thyroid ultrasound, linear probes, 7.5 MHz. ii) New description – 10 ETP: pattern 0, lack of thyroid; 1, marked hypoechogenous pseudonodular; 2, hypoecogen homogenous; 3, micronodular hypoechogenous; 4, macro (>10 mm; ±micro) nodular; 5, inhomogeneous...

ea0032p1063 | Thyroid (non-cancer) | ECE2013

Superior vena cava syndrome due to enlarged thyroid gland

Cakir Evrim

Blood flow obstruction through superior vena cava leads to superior vena cava syndrome (VCSS). The most common cause of the VCSS is malignancies. Enlargement goitre is an unusual cause of VSSS. A patient with superior vena cava syndrome secondary to enlarged thyroid gland was presented in this case report. An 84-year-old man presented to endocrinology unit with gradually increasing neck mass, dysphagia, and shortness of breath. His physical examination revealed webbed neck wit...

ea0032p1064 | Thyroid (non-cancer) | ECE2013

The change of character in passing of Graves' disease in St Petersburg from 1970 to 2010

Dora Svetlana , Krasilnikova Elena , Volkova Anna , Grigorieva Evgenia

The diseases of a thyroid gland belong to the most frequent pathology which is met among people. The prevalence and structure of pathology of a thyroid gland, first of all, depends from the level of a iodine status in the population. The first time the assessment of an iodine status in St Petersburg was carried out in 1999 by the staff of faculty therapy of Saint-Petersburg State Medical University named after academician I.P Pavlov. The median urinary iodine ...

ea0032p1065 | Thyroid (non-cancer) | ECE2013

Subclinical autoimmune thyroid disease and cardiovascular risk factors

Neves Celestino , Esteves Cesar , Pereira Miguel , Palmares Carmo , Sokhatsha Oksana , Dias Camila , Delgado Luis , Carvalho Davide , Luis Medina Jose

Objective: To examine whether Graves’ disease (GD) and autoimmune thyroiditis (AIT) are associated with insulin resistance and other cardiovascular risk factors.Subjects and methods: We recorded thyroid function tests, BMI, insulin resistance markers comprising the homeostasis model assessment for insulin resistance (HOMA-IR and HOMA-B), the quantitative insulin sensitivity check index (QUICKI), hepatic insulin sensitivity index (HISI), whole-body i...

ea0032p1066 | Thyroid (non-cancer) | ECE2013

Subclinical hypothyroidism, autoimmune thyroiditis, and cardiovascular risk factors

Pereira Teresa , Neves Celestino , Esteves Cesar , Camila Dias Claudia , Pereira Miguel , Sokhatska Oksana , Delgado Luis , Carvalho Davide , Luis Medina Jose

Aim: To evaluate the relationship between autoimmune thyroiditis (AIT), subclinical hypothyroidism (SCH) and cardiovascular risk factors.Patients and methods: We recorded thyroid function tests, BMI, insulin resistance markers comprising the homeostasis model assessment for insulin resistance (HOMA-IR and HOMA-B), the quantitative insulin sensitivity check index (QUICKI), hepatic insulin sensitivity index (HISI), whole-body insulin sensitivity index (WBI...

ea0032p1067 | Thyroid (non-cancer) | ECE2013

Marine–lenhart syndrome

Esteves Cesar , Neves Celestino , Vieira Tiago , Pereira Jorge , Carvalho Davide

Introduction: The Marine–Lenhart syndrome is a rare cause of hyperthyroidism that is associated with the simultaneous or sequential presence of characteristics related to Graves’ disease and toxic nodular or multinodular goiter. It’s validity as a disease is controversial and some authors believe that these are cases of hyperthyroidism where both etiologies coexist. The presence of hyperfunctioning nodules in Graves’ disease patients ranges between 0.8 and ...

ea0032p1068 | Thyroid (non-cancer) | ECE2013

Is Hashimoto's thyroiditis in children different from adults? A prospective comparative study

Bhargav Panchangam Ramakanth

Background: Hashimoto’s thyroiditis (HT) is the commonest cause of spontaneous hypothyroidism. We compared clinico-investigative profile between child HT vs adult HT.Material and methods: The study was conducted in Endocrine surgery department in a teritiary care hospital. The data was analyzed seperately for Group A: child HT (below 18 years) and Group B: adult (above 30 years).Results: The study period was 30 months (October...

ea0032p1069 | Thyroid (non-cancer) | ECE2013

Evolution of thyroid function in Hashimoto thyroiditis and related disorders: December 2012

Poiana Catalina , Carsote Mara , Staicu Daniela Cristina , Clodeanu Alexandrina , Peretianu Dan

Aim: Analyzing the evolution of thyroid function in thyroiditis and related disease during 1–17 years.Materials and methods: i) Diagnostic: Hashimoto’s thyroiditis (HT): a) antithyroperoxydase antibodies (ATPO) cut-off 34 IU/ml. b) If ATPO=normal, thyroiditis was considered if high antithyroglobuline antibodies (T-ATG). c) Idiopathic mixedema (IM): hypothyroidism, no ATPO, no ATG, and no TRAB. ii) Patients: HT: 1196; T-ATG: 73; IM: 69. Women/me...

ea0032p1070 | Thyroid (non-cancer) | ECE2013

Abstract unavailable....

ea0032p1071 | Thyroid (non-cancer) | ECE2013

Autoimmune hypo to hyperthyroidism: a rare evolution

Marcelino Mafalda , Silva Joao , Passos Dolores , Jacome de Castro Joao

Introduction: Hashimoto thyroiditis (HT; with anti-thyroid peroxidase antibodies (TPOAb)) and Graves’ disease (GD; with TSH receptor antibodies (TRAbs)) are frequent autoimmune disorders responsible for thyroid dysfunction. There are two types of TRAbs, the ones that stimulate the thyroid (TSAb) causing Graves’ hyperthyroidism and those that block thyrotropin action (TBAb) being occasionally responsible for hypothyroidism. Unusual patients switch from TSAb to TBAb (o...

ea0032p1072 | Thyroid (non-cancer) | ECE2013

The cause of haematoma on the anterior neck

Srbova Libuse

Introduction: Spontaneous cervical haematomas represent a rare condition. Few case reports have been published concerning spontaneous haematomas visible on the anterior side of a neck. These were caused by rupture of the superior thyroid artery, rupture of a thyroid nodule or the thyroid. A case of sternocleidomastoid haematoma due to haemorrhage into a nodal deposit of non-Hodgkin’s lymphoma has also been described.Case report: A 39-year-old woman ...

ea0032p1073 | Thyroid (non-cancer) | ECE2013

Acute respiratory failure in a rapidly-enlarging benign cervical goiter

Jan Garingarao Carlo , Anonuevo-Cruz Cecille , Gasacao Ryan

Benign goitres have the potential to reach massive sizes if neglected, but most have a protracted course that may or may not present with compressive symptoms. We report the case of a 57-year-old male who presented with a rapidly enlarging nodular goitre resulting in acute respiratory failure. Endotracheal intubation and emergency total thyroidectomy was done, revealing massive thyroid nodules with minimal intrathoracic extension and tracheal erosion. Despite a course and clin...

ea0032p1074 | Thyroid (non-cancer) | ECE2013

Vitiligo: anti-thyroid peroxidase antibody

Anca Chiriac , Liliana Foia , Anca Chiriac E , Claudia Miron , Caius Solovan , Cristina Birsan , Mihaela Moscalu , Roxana Stanciu

Vitiligo is a common skin depigmenting disease, which is thought to have, at least partly, an autoimmune etiology.Our objective was to compare the frequency of thyroid peroxidase antibody (anti-TPO) in vitiligo patients over a period of 3 years (2010–2012) in our Department.Methods: Anti-TPO levels were assessed in order to detect any correlation with the onset, the evolution and the treatment of vitiligo. Patients with vitili...

ea0032p1075 | Thyroid (non-cancer) | ECE2013

Protective antioxidative effects of caffeic acid phenethyl ester in the thyroid and the liver are similar to those caused by melatonin

Kokoszko-Bilska Agnieszka , Stepniak Jan , Lewinski Andrzej , Karbownik-Lewinska Malgorzata

Whereas oxidative reactions occur in all tissues and organs, the thyroid gland constitutes such an organ, in which oxidative processes are indispensable for physiological functions. Thus, with additional oxidative abuse caused by several factors, increased oxidative damage to macromolecules may occur in the thyroid. In turn, numerous metabolic reactions occurring in the liver create favourable conditions for huge oxidative stress.Melatonin is a well-know...

ea0032p1076 | Thyroid (non-cancer) | ECE2013

Use of scintigraphy in the current diagnosis of thyroid diseases

Nyvltova Monika , Vodak Miroslav , Drbalova Karolina , Zavoral Miroslav

Introduction: Scintigraphy had long been the only modality for thyroid gland imaging. With the development of other imaging techniques (sonography, CT, MRI), the role of scintigraphy has gradually diminished. However, it cannot be completely ignored, as it is the only technique to image not only the morphological structure, but also the functional status of the thyroid gland. In the current clinical practice, thyroid scintigraphy is performed with 99mTc pertechnetat...