Searchable abstracts of presentations at key conferences in endocrinology
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15th European Congress of Endocrinology


New mechanisms in SST analogue response

ea0032s11.1 | New mechanisms in SST analogue response | ECE2013

Functional relevance of truncated SST5 receptor variants

Luque Raul M , Ibanez-Costa Alejandro , Gahete Manuel D , Castano Justo P

Somatostatin (SST) and its related peptide cortistatin (CORT) exert multiple physiological actions through binding to a family of G-protein coupled receptors (sst1–sst5), commonly bearing seven transmembrane domains (TMDs). However, we have recently discovered that human, pig and rodent sst5 gene also generate, through non-canonical alternative splicing, novel truncated albeit functional sst5 variants that lack one o more TMDs. Our studies indicate that truncated sst5 var...

ea0032s11.2 | New mechanisms in SST analogue response | ECE2013

Role of filamin A in dopamine and somatostatin receptor targeting in the pituitary

Peverelli Erika

Molecular mechanisms underlying resistance of pituitary tumors to somatostatin (SS) and dopamine (DA) analogs treatment are not completely understood. Resistance has been associated with defective expression of functional SS (SSTR2–5) and DA (DRD2) receptors. The role of cytoskeleton proteins in receptor trafficking, anchoring to the plasma membrane and signalling has been demonstrated in other tumoral cell systems. In particular, filamin A (FLNA) seems to be a good candi...

ea0032s11.3 | New mechanisms in SST analogue response | ECE2013

Role of ERK in somatostatin receptor signalling

Barlier Anne , Romano David , Zeiller Caroline , Roche Cathy , Pertuit Morgane , Gerard Corinne

The Ras/Raf/MEK/ERK is a conserved signalling pathway involved in the control of fundamental cellular processes. Despite extensive research, how this pathway can process a myriad of diverse extracellular inputs into specific biological outcomes is not fully understood. Particularly, the role of this pathway in neuroendocrine tumoral cells remains unclear.We have previously shown that the ERK1/2 pathway is an integrative point in the control of the pituit...