Endocrine Abstracts

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Diabetes insipidus (DI) is a syndrome caused by various defects in the secretion or action of the antidiuretic hormone, arginine vasopressin (AVP). They include impaired AVP production (pituitary DI), increased AVP degradation (gestational DI), suppression of AVP secretion by excessive water intake (primary polydipsia) or decreased antidiuretic effect due to various abnormalities in the kidney (nephrogenic DI). In all four types, the severity of the defect varies between patie...

The water channel aquaporin-2 (AQP2) of the kidney connecting tubule and collecting ducts, plays an essential role in maintaining body water balance. AQP2 is regulated by the peptide hormone arginine vasopressin (AVP), which exerts parts of its effects through the type 2 vasopressin receptor (AVPR2), expressed throughout the distal nephron. Disrupted function or regulation of AQP2 or the AVPR2 results in nephrogenic diabetes insipidus (NDI). NDI is a common clinical condition ...