Introduction: Lactose intolerance itself is linked with lower peak bone mass (PBM) and with decreased bone mineral density (BMD) which may decrease further with lactose intolerance associated comorbidities. The aim of our study was to examine how bone metabolic parameters are affected (change of bone metabolism markers, BMD and frequency of fractures) in lactose intolerance which was accompanied by previously diagnosed hyperlipidemia or by hypothyroidism.
Description of methods: Forty-three female patients (34.88±4.4 years) with lactose intolerance were divided into three groups: n=16 female patients (32.8±4.4 years) with lactose intolerance only (1), n=13 female patients (35.6±4.2 years) with lactose intolerance and previously diagnosed hyperlipidemia (2) and n=14 female patients (36.5±2.9 years) with lactose intolerance and treated hypothyroidism (3). BMD was measured by dual-energy X-ray absorptiometry (DEXA) at the one third of distal radius, the femoral neck and the lumbar spine region (L2L4). Laboratory analysis included routine and also calcium metabolism parameters such as: 25-hydroxyvitamin D (25-OHD3), parathyroid hormone (PTH), β-CrossLaps, 25-OH D3- vitamin D, osteocalcin (OC). Also prevalence of fractures was recorded. Statistical analysis was performed by ANOVA, with post-hoc test Bonferroni.
Results: Bone fractures, BMD and vitamin D levels differ among the groups significantly (P<0.05). The highest frequency of bone fractures was observed in patients with lactose intolerance and previously diagnosed hyperlipidemia (0.84/patient) which was accompanied by the lowest 25OH vitamin D level (26.08±9.25 nmol/l) and bone mineral density in femoral neck region (Zsc: −1.29±0.21).
Conclusion: The recognition of lactose intolerance in time, special attention for associated comorbidities (e.g. lactose intolerance with hyperlipidaemia) and choosing the proper treatment (e.g. sufficient supplementation of vitamin D) should become part of the osteological and fracture prevention of women in fertile age.