Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2013) 32 P158 | DOI: 10.1530/endoabs.32.P158

ECE2013 Poster Presentations Calcium and Vitamin D metabolism (62 abstracts)

Comparative study of bone metabolic parameters and vitamin D levels of fertile aged women, suffering from different bone metabolism altering diseases

Orsolya Acs 1 , BenceT Acs 1, , Csaba Horvath 3 , Viktoria Ferencz 3 , Szilvia Meszaros 3 , Edit Toth 4 & Emoke Csupor 5

1Semmelweis University School of Ph.D. Studies, Budapest, Hungary; 22nd Department of Internal Medicine, Semmelweis University, Budapest, Hungary; 31st Department of Internal Medicine, Semmelweis University, Budapest, Hungary; 4Department of Rheumatology, County Hospital Flor Ferenc, Budapest, Hungary; 5The Health Service of Budavari Local Authorities, Endocrinology, Budapest, Hungary.

Introduction: Polycystic ovary syndrome (PCOS), lactase deficiency, nephrolithisasis and thyroid diseases are considered endemic. The aim of our study was to evaluate which of the above-mentioned diseases affect the most the bone metabolic parameters, bone mineral density (BMD) and the prevalence of bone fractures in fertile aged women.

Materials and methods: A total of 92 fertile aged women (32.6±5.2 years) were divided into four groups (23 in each) according to their diseases (PCOS or lactase deficiency or nephrolithiasis or treated hypothyroidism). BMD was measured by dual-energy X-ray absorptiometry (DEXA). Laboratory analysis included routine and also calcium metabolism: 25-hydroxyvitamin D (25-OHD3), parathyroid hormone (PTH), β-CrossLaps, 25-OH D3-vitamin D, osteocalcin (OC). The prevalence of bone fractures were also recorded. Statistical analysis was performed by ANOVA, with post-hoc Bonferroni’s correction (Satistica Software 9.0).

Results: After comparing the results of the groups, women with nephrolithiasis had the lowest BMD (Zsc: −0.92±0.35) (P<0.05) in the region of lumbar spines (L2–4), the lowest BMD (Zsc: −1.33±0.43) (P<0.05) in the region of the femoral neck, and lowest BMD (Zsc: −1.1.9±0.31) (P<0.05) at the one third of distal radius among all groups. The average bone fracture rate of the 92 fertile aged women was high (40.8%), and serum 25-(OH) vitamin D3 levels were low (27.8±6.1–36.4±6.4 nmol/l) comparing to the normal range.

Conclusion: The recognition and treatment (for e.g. sufficient supplementation of vitamin D) of endemic diseases in women in fertile age should become part of the osteological and fracture prevention.

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