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Endocrine Abstracts (2013) 32 P212 | DOI: 10.1530/endoabs.32.P212

Department of Endocrine and Metabolic Diseases, Bab Oued Hospital, Algiers, Algeria.

Introduction: Glucose metabolism disorders are well known in subjects with GH excess, but little is known about other metabolic abnormalities. Our aim is to analyze metabolic complications in subjects with acromegaly and pituitary gigantism.

Subjects and methods: Records of 111 subjects were retrospectively examined, mean GH=62 ng/ml (n<5), mean age=39.11 (14–60). All had routine analysis for fasting blood glucose, cholesterol, triglycerides, calcium and phosphorus. They all had oral glucose tolerance test (75 g glucose) with glucose measurement during two hours. Hormonal assessment was based on GH and IGF1 (when possible), prolactin, cortisol, ACTH, TSH, FT4, FSH, LH, and testosterone or estradiol (according to their sex). Radiological exploration was based on CT scan, MRI or both.

Results: Among this group 44.8% had gonadotrop deficiency, 22% thyreotrop and 21% corticotrop deficits, because of their pituitary tumours (mean volume 11.4 cm).

For metabolic disorders: 58.5% had glucose metabolism disorders, 54% hypercholesterolemia and/or hypertriglyceridemia, 31% hyper phosphataemia, and 10% hyperparathyroidism.

Conclusion: Our subjects, living in a developing country, with GH excess, are at very high risk of cardiovascular diseases because of their metabolic disorders, especially glucose and lipids abnormalities which are higher than recent Poland and Belgium studies in Europe.

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