Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2013) 32 P386 | DOI: 10.1530/endoabs.32.P386

ECE2013 Poster Presentations Diabetes (151 abstracts)

Maternal serum fetuin-A, leptin, and hs-CRP concentrations in gestational diabetes

Mehmet Calan 2 , Ozgur Yilmaz 1 , Tamer Altindag 3 , Ahmet Solak 4 , Levent Kebabcilar 5 , Huseyin Oguz Yuvanc 6 & Tuba Dal 6

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1Department of Obstetrics and Gynecology, Manisa Akhisar State Hospital, Manisa, Turkey; 2Division of Endocrinology and Metabolism, Department of Internal Medicine, Dokuz Eylul University, Izmir, Turkey; 3Department of Obstetrics and Gynecology, Bursa Acibadem Hospital, Bursa, Turkey; 4Department of Biochemistry, Van Ipekyolu Hospital, Van, Turkey; 5Division of Endocrinology and Metabolism, Department of Internal Medicine, Selcuklu, Medical Faculty, Konya, Turkey; 6Department of Obstetrics and Gynecology, Diyarbakir, Turkey.


Aim: The aim of this study was to examine serum fetuin-A, leptin and hs-CRP concentrations among pregnant women with gestational diabetes (GDM), and to evaluate the relationship between these parameters and insulin resistance.

Materials and methods: In this study, we evaluated 47 pregnant patients with GDM. As the control group, 43 normal pregnant women having similar properties with these GDM patients, but not gestational diabetes were enrolled. Serum fetuin-A, leptin, and high sensitive CRP (serum reactive protein) levels of both groups of pregnants were measured. Insulin sensitivity and insulin resistance were calculated by QUCKI-IS (quantitative insulin check index) and HOMA-IR (homeostasis model assessment of insulin resistance) methods respectively.

Results: Fasting serum glucose levels (P<0.001), fasting serum insulin levels (P=0.002), HOMA-IR index (P=0.001), serum leptin levels (P=0.002), and serum hs-CRP levels (P<0.001) of the women with GDM were found statistically significantly higher than the control group. Serum fetuin-A levels and HOMA-β index showed no statistically significant difference between the two groups.

Conclusion: Pregnant women with and without GDM were compared in terms of serum fetuin-A levels and no statistically significant difference was detected between the two groups. In addition, insulin resistance calculated by HOMA-IR and fetuin-A showed no significant correlation between the two groups of patients. Serum leptin and hs-CRP concentrations increased in women with GDM, and a significant positive correlation was found between serum leptin hs-CRP and insulin resistance

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