Endocrine Abstracts

There is a need in study of resistin (R) role in the pathogenesis of nonalcoholic fatty liver disease (NAFLD) against the background of metabolic disorders.

Aim: To assess the relationship between R and indexes of enzyme and pigment metabolism in patients (pts) with NAFLD combined with diabetes mellitus (DM) type 2 and obesity (Ob).

Methods: Fifty pts with NAFLD in combination with subcompensated DM (HbA1c 8.3±1.7%) and Ob (BMI≥30 kg/m²) were examined. The control group included 20 healthy individuals. The R was determined by ELISA method. All patients underwent ultrasound investigation of liver and also liver biopsy.

Results: The level of R in pts was increased (10.0±0.11 ng/ml; P<0.001) in comparison with the control (4.87±0.11 ng/ml). The correlation was established between R and aspartate aminotransferase (r=0.57; P<0.05), alanine aminotransferase (r=0.49; P<0.05), total bilirubin (r=0.59; P<0.05), conjugated bilirubin (r=0.71; P<0.05), alkaline phosphatase (r=0.82; P<0.05).

Conclusion: The increase of resistin level can negatively affect the pathogenesis of NAFLD, amplifying the processes of cytolysis, cholestasis and fibrogenesis in patients with comorbid DM and Ob.