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Endocrine Abstracts (2013) 32 P481 | DOI: 10.1530/endoabs.32.P481

ECE2013 Poster Presentations Diabetes (151 abstracts)

Protective effects of Swietenia macrophylla King (seed & endocarp) aqueous-methanolic extract on pancreatic islet histology in streptozotocin-induced diabetic rats

Hanan Kumar Gopalan , Nur Hayati Jafaar Marican , Rahim Mhd Noah & Rohani Mat Jais


UNIKL Institute Medical Science Technology, Kajang, Malaysia.


The oral antidiabetic drug, glibenclamide, stimulates the insulin producing β-cells constantly through a harsh mechanism which eventually may permanently reverse its endocrinofunction. The study investigates the protective effects from Swietenia seed and endocarp aqueous-methanol extract on pancreatic islets histology in rats of type 2 DM model. Phytochemical analyses were performed prior to the in vivo study to screen the aqueous-methanolic extract of the combined plant parts. The experimental groups were rendered diabetic by chemical combination of STZ (65 mg/kg bwt, i.v.) and NAD (230 mg/kg bwt, i.p.) in adult rats. Diabetic rats were orally force-fed with glibenclamide (5 mg/kg bwt) or extracts (250 mg/kg bwt) daily for 3 weeks. Body weight (g) and FBG levels (mg/dl) were determined at treatment intervals of 0, 7, 14 and 21. Subsequently, Langerhans’ islets were examined by H&E staining. Photomicrographs of pancreatic islet revealed that administration of extracts showed improved cellular density suggesting that the extracts were capable of inducing β-cells recovery and/or regeneration following destructive effects of STZ. Findings indicate that Swietenia macrophylla King seed and endocarp aqueous-methanolic extract exhibits protective effect on islet histology and were also involved in correction of altered biological parameters. Hence, it may serve as candidate for developing a safe, complaisance and promising neutraceutical for the management of diabetes.

Key Words: Swietenia macrophylla King, Diabetes, islet of Langerhans, Streptozotocin, Rats.

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