Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2013) 32 P585 | DOI: 10.1530/endoabs.32.P585

ECE2013 Poster Presentations Female reproduction (47 abstracts)

Thrombin generation in polycystic ovary syndrome: a marker of thrombosis

Mubeena Aziz 1 , Johannes J Sidelmann 2 , Sven O Skouby 3 & Jens Faber 4


1Department of Obstetrics/Gynecology, Herlev University Hospital, Herlev, Denmark; 2Unit for Thrombosis Research, Institute of Public Health, University of Southern Denmark, Esbjerg, Denmark; 3Department of Obstetrics/Gynecology, Herlev University Hospital, Faculty of Health Sciences, University of Copenhagen, Herlev, Denmark; 4Department of Endocrinology, Herlev University Hospital, Faculty of Health Sciences, University of Copenhagen, Herlev, Denmark.


Background: Polycystic ovary syndrome (PCOS) is clinically associated with increased risk of CVD. Thrombin generation (TG) is a measure of the thrombotic potential. This can be expressed as endogenous thrombin potential (ETP) representing the total amount of generated active thrombin over the time (nmol/l×min). ETP is considered the most predictive parameter of thrombosis and is associated to both venous and arterial thrombotic disease. Setting: PCOS women prospectively referred to three Danish Gynecological clinics due to infertility, hirsutism and oligo-/amenorrhea.

Materials and methods: One hundred and forty-eight PCOS women diagnosed according to the Rotterdam criteria, mean age 27 years (range 18–40). Measurements: BMI, plasma TG, hsCRP, PAI-1, HOMA-IR, body composition (DXA) and urinary-albumin/creatinin. The calibrated automated thrombogram was used to measure TG.

Results: ETP levels were divided into tertiles:

Total and free testosteron, u-albumin/creatinin did not correlate to ETP. The correlation to total fat mass (TFM) seemed equal to both android and gynoid fat.

ETP did not correlate to number or combinations of the Rotterdam criteria. In a univariate analysis, ETP correlated to the majority of the above-mentioned parameters. In a multivariate analysis including TFM, HOMA-IR, hsCRP, total and LDL-cholesterol, triglycerides, ETP was independently associated with TFM and total cholesterol (β=0.358, P=0.025; β=0.482, P=0.022 respectively).

Table 1
1134.5 ≤ 16951695.1 – 1913.51913.6 – 3026P-value (ANOVA)
n504949
BMI25±427±428±40.004
HOMA-IR0.84±2.60.98±2.11.24±3.20.040
Total fat mass (kg)7.7±2.69.7±2.810.3±3.20.001
hsCRP0.57±2.90.97±3.31.41±2.80.000
PAI-111.6±4.613.9±1.917.6±1.90.015

Conclusion: Increasing ETP is associated with a number of parameters traditionally associated with increased risk of CVD in PCOS. This association seems mainly driven by total FM and cholesterol in PCOS. The Rotterdam criteria were unable to detect this signal of potentially increased risk of thrombosis.

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