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Endocrine Abstracts (2013) 32 P597 | DOI: 10.1530/endoabs.32.P597

University of Chile, Santiago, Chile.


Polycystic ovary syndrome (PCOS) is an important metabolic and reproductive disorder which confers substantially increased risk for type two diabetes and metabolic syndrome (MS). Our aim is to characterize the metabolic profile, insulin sensitivity (IS) and insulin secretion in control (Cw) and PCOS women (PCOSw) during different stages of reproductive life (S1: 18–35 years old, S2: 36–44 years old, S3: 45–55 years old). A total of 131 Cw and 129 PCOSw were included, distributed as follows: S1: 69 Cw and 78 PCOSw, S2: 46 Cw and 40 PCOSw, S3: 16 Cw and 11 PCOSw. Clinical and anthropometric characteristics were evaluated. In both groups, a 2 h, 75 g OGTT was performed with measurement of glucose, insulin and lipids. HOMA-IR, insulin sensitivity index (ISI) composite, HOMAbeta, insulinogenic index and area under the curve for glucose and insulin were calculated. MS was evaluated according to the modified NCEP ATP III criteria. Chronological age, BMI, anthropometrics and fasting glucose were similar between Cw and PCOSw in the three study periods; 2-h glucose increased with age in PCOSw. Stage 1 and 2 PCOSw showed a higher prevalence of hypertension, hypercholesterolemia and hypertriglycerides compared to CW.

Table 1
S1S2S3
CwPCOSwCwPCOSwCwPCOSw
ISI composite6.4 (1.2–23)4.4* (0.4–11)6.6 (1.4–21)5.0* (0.8–12)5.3 (1.6–8)4.6 (0.7–4.7)
Homa-B383 (60–4420)327 (60–1226)230(41–1079)180 (26–484)183 (76–377)176 (48–321)
Insulinogenic index2.6 (0.1–26.6)2.8 (0.1–12.6)1.3 (0.1–6.6)1.9 (0.1–6.5)1.6 (0.3–5.1)1.9 (0.5–6.6)
AUC insulin7060 (1627–26269)11383 * (2289–40673)6303 (975–35881)9331* (1809–33392)6134 (3263–14730)7769 (1637–31880)
MS (%)1325*1834*1318

The present study shows that during reproductive age, PCOSw are more affected metabolically than Cw. Nevertheless during the perimenopausal period, Cw are metabolically more perturbed showing a similar metabolic profile to PCOSw.

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