Introduction: Polycystic ovary syndrome (PCOS) is widely diagnosed among young women in reproductive age. Vitamin D deficiency has been known as a common problem in all ages and also in a recent study which performed in a small study groups, reported that it may accompany with hyperandrogenism. The aim of our study is to evaluate serum 25(OH)D3 levels in PCOS patients compared with healthy control and relation to androgen levels.
Methods: Forty-three native patients diagnosed as PCOS according to Rotterdam criteria and 24 healthy controls were recruited to the study. Weight, length, waist circumference, fat mass, glucose, insulin, lipid profiles, total and free testosterone, DHEAS, FSH, LH and 25(OH)D3 levels were measured during follicular phase of menstruation. BMI and HOMA-IR were calculated.
Results: Age, BMI, waist circumferences and fat mass were not different between the groups. Vitamin D levels in PCOS patients were lower than healthy control (18.9±8.2, 20.6±6.6 ng/ml respectively) but the difference was not statistically significant (P>0.05). When PCOS group was divided in two subgroups according to the androgen levels (21 normoandrogenic; 24 hyperandrogenic), the result was not changed. Total and free testosterone and DHEAS levels of hyperandrogenic PCOS group were insignificantly higher than control and normoandrogenic PCOS group (P<0.001, P<0.05 and P<0.001 between groups respectively). There was no correlation between androgen and vitamin D levels.
Conclusion: Vitamin D deficiency is very common in Turkish population and we found that it is same for PCOS patients. In our study, androgen levels were not correlated with 25(OH)D3 levels, thus we could not have found any difference between the groups according to the vitamin D levels.