ECE2013 Poster Presentations Male reproduction (41 abstracts)
Investigation on psychological symptoms improves ANDROTEST accuracy in predicting hypogonadism in subjects with sexual dysfunction
Giulia Rastrelli 1 , Giovanni Corona 1, , Elisa Bandini 1 , Carolina Strada 1 , Elisa Maseroli 1 , Valdo Ricca 1 , Carlo Faravelli 1 , Edoardo Mannucci 1 & Mario Maggi 1
1University of Florence, Florence, Italy; 2Maggiore Hospital, Bologna, Italy.
The role of psychological symptoms in recognizing late-onset hypogonadism (LOH) is still controversial. The aim of the study is to evaluate the association between LOH and specific psychological symptoms and to verify whether investigating intra-psychic domain improves the accuracy of a validated case-history tool (ANDROTEST) in detecting LOH. A consecutive series of 1009 subjects (mean age 49.23±13.34) consulting for sexual dysfunction was studied. Intra-psychic symptoms were investigated by Middlesex Hospital Questionnaire (MHQ), a self-reported questionnaire for screening of mental disorders.
A minimum set of 2 MHQ items was identified through iterative ROC curve analysis, with assessment of sensitivity and specificity for hypogonadism (calculated free testosterone <0.225 nmol/l) in an exploratory sample of 462 patients. Sensitivity and specificity were verified in a validation sample of 547 subjects, in which the final 2-item version showed an accuracy of 58.4±3.2% in detecting hypogonadism. The combination of the 2-item score with ANDROTEST increased the accuracy in predicting hypogonadism (0.741±0.029; P<0.0001), when compared to ANDROTEST (0.696±0.018; P<0.0001) and the 2-item score (P<0.05) alone. Hence, combining these two psychological symptoms with a physical scoring system improves its ability in detecting hypogonadism. The combination of the scores should be tested in other studies.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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