ECE2013 Poster Presentations Neuroendocrinology (42 abstracts)
Features of family inheritance in patients of non-functional pituitary adenomas in Uzbekistan
Zamira Khalimova 1, , Dilorom Sharipova 1, , Rovshan Fayzullaev 1, , Yulduz Urmanova 1, , Dinara Alieva 1, , Gulrukh Alimukhamedova 1, , Munira Karimova 1, & Shokhsanam Safarova 1,
1The Center for the Clinical and Scientific Study of Endocrinology, Tashnet, Mirzo Ulugbek str 56, Uzbekistan; 2Tashkent Pediatric Medical Institute, Tashkent, Uzbekistan.
Aim: To study features of family inheritance in patients of non-functional pituitary adenomas (NFPA) in Uzbekistan.
Materials and methods: We included 71 patients with NFPA, intrasellar localization (mean size >3 mm). Mean age was from 18 to 70 years old (range 44.5±3.85 years). Of 71 patients, 30 (42.3%) were men and 41 (57.7%) were women.
All patients underwent clinical and biochemical evaluations including endocrine check, lipid profile, hormonal profile (LH, FSH, prolactin, STH, TSH, etc.), genitalia ultrasonography, CT/MRI of pituitary, visual fields, genetic methods if investigation (FNO-&, proapoptosis protein of gene p53, antiapoptosis protein of gene of bcl-2, activity of factors of angiogenesis-VGFE, VGFER-2, eNOS-3) and study of family anamnesis.
Results: In this investigation, we disjointed 71 patients with NFPA into two groups: group 1 – without hereditary load – 50 (70.4%) and group 2 with hereditary load – 21 (29.6%), including panmixia – 9 (2.7%) and inbreeding –12 (16.9%) patients.
The clinical analysis submitted that in patients with inbreeding, the onset of disease has been diagnosed at 3–5 years earlier, more often in young age – before 28–35 years, than in patients with panmixia.
Conclusion: i) On the base of in-depth study of features of NFPA, we found in our patients with NFPA 2 types of family inheritance: panmixia (73.8%) and inbreeding (26.8%). ii) In patients with inbreeding more frequently happen in women with mean size of tumor in the range 8–10 mm, but in patients with panmixia – equality in men and women with mean size until 8 mm.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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