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41st Meeting of the British Society for Paediatric Endocrinology and Diabetes

Oral Communications

Oral Communications 3

ea0033oc3.1 | Oral Communications 3 | BSPED2013

Catch up growth and insulin sensitivity in adolescent children born preterm

Embleton Nicholas , Korada S Murthy , Wood Claire , Pearce Mark , Swamy Ravi , Cheetham Timothy

Background: Preterm infants represent around 10% of births worldwide and have increased risk of adverse metabolic outcomes in later life. The approach to feeding preterms must balance the need to promote brain growth by providing adequate nutrients whilst avoiding potentially harmful excess nutrition.Objective: To investigate the association between patterns of weight gain in infancy and childhood with later insulin sensitivity in adolescents who were bo...

ea0033oc3.2 | Oral Communications 3 | BSPED2013

GAD and IA2 autoantibody positivity is associated with a requirement for insulin treatment: results of the UK national paediatric Type 2 Diabetes cohort

Gray Zoe , Ilsley Emma , Cotter Catherine , Makusha Lydiah , Ford Anna , Turner Kelly , Heywood James , Chandler Kyla , Bingley Polly , Barnett Anthony , Dunger David , Shield Julian , Wales Jeremy , Barrett Timothy

Objectives: To establish the frequency of islet cell autoimmunity in children with a clinical diagnosis of type 2 diabetes (T2DM) and describe associated clinical and laboratory findings.Methods: We recruited children with: paediatrician diagnosis of T2DM; BMI above 85th centile for age and sex; children with other confirmed diagnoses such as monogenic and type 1 diabetes (T1DM) were excluded. Clinical data was collected into a national database. Blood w...

ea0033oc3.3 | Oral Communications 3 | BSPED2013

Successful treatment of four patients with severe hyperinsulinaemic hypoglycaemia with a novel therapy using mTOR inhibitor

Senniappan Senthil , Alexandrescu Sanda , Tatevian Nina , Shah Pratik , Arya Ved , Flanagan Sarah , Ellard Sian , Rampling Dyanne , Ashworth Michael , Brown Robert , Hussain Khalid

Introduction: Hyperinsulinaemic hypoglycaemia (HH) is the most common cause of severe and persistent hypoglycaemia in neonates. The treatment of diazoxide unresponsive HH involves pancreatectomy. Mammalian target of rapamycin (mTOR) is a protein kinase that regulates cellular proliferation. We aimed to evaluate the efficacy of mTOR inhibitor Sirolimus and assess mTOR expression in the pancreas of infants with severe HH.Methods: Four infants with severe, ...

ea0033oc3.4 | Oral Communications 3 | BSPED2013

Successful Use of Long Acting Octreotide in Treatment of Congenital Hyperinsulinism

Shah Pratik , Gilbert Clare , Morgan Kate , Hinchey Louise , Senniappan Senthil , Arya Ved , Levy Hannah , Hussain Khalid

Introduction/Aim: Congenital hyperinsulinism (CHI) is a cause of severe hypoglycaemia in infancy. Treatment of diazoxide unresponsive patients includes the use of somatostatin analogues (octreotide given either as four s.c. injections daily or via a pump). We aimed to evaluate the use of a long acting somatostatin analogue (Lanreotide) in children with CHI, switching them from daily oral diazoxide or s.c. Octreotide injections to 4 weekly Lanreotide injections.<p class="ab...

ea0033oc3.5 | Oral Communications 3 | BSPED2013

Loss of the tumour suppressor micro-RNA 34a, and anti tumour cellular immunity in paediatric obesity – is obesity increasing the future risk of cancer in children?

Carolan Eirin , Hogan Andrew , Corrigan Michelle , O'Connell Jean , Foley Niamh , O'Neill Luke , Cody Declan , O'Shea Donal

There is strong epidemiological data linking obesity to an increased risk of various cancers. It is associated with immune dysregulation and chronic low grade inflammation, however little is known about its impact on anti-tumour immunity. Whether childhood obesity is an independent risk factor for future malignancy is not fully established. We hypothesized that alterations in key immune anti-tumour mechanisms begin prior to adulthood in paediatric obesity.<p class="abstext...

ea0033oc3.6 | Oral Communications 3 | BSPED2013

A feasibility study of intra-gastric balloons (supported by a lifestyle programme) for the treatment of severe adolescent obesity – the (BOB) Study.

Sachdev Pooja , Reece Lindsey , Copeland Rob , Wales Jerry , Wright Neil

Rationale: Although many adolescents meet the NICE criteria for bariatric surgery there is a reluctance to undertake or commission such irreversible procedures in young people. Balloons are temporary, reversible, safer and more acceptable and in adults have been shown to promote a clinically significant change in BMI of 4.0–9.0 kg/m2 But due to subsequent weight regain, bypass surgery is preferred.This is a feasibility study of endocsopic...