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41st Meeting of the British Society for Paediatric Endocrinology and Diabetes

Oral Communications

Oral Communications 4

ea0033oc4.1 | Oral Communications 4 | BSPED2013

Risk factors for emergency hospital admission for diabetic ketoacidosis in children and young people: national cross-sectional analysis

Khare Swarna , Soljak Michael , Warner Justin , Amin Rakesh , Saxena Sonia , Viner Russell , Majeed Azeem , Modi Neena

Objectives: To identify patient and clinical factors associated with emergency hospital admission with diabetic ketoacidosis (DKA) in children and young people with type 1 diabetes attending specialist NHS outpatient clinics in England and Wales.Design: Cross-sectional observational analysis of linked data from the National Paediatric Diabetes Audits (NPDAs) in England and Wales, and Hospital Episode Statistics and Patient Episode Database for Wales. We ...

ea0033oc4.2 | Oral Communications 4 | BSPED2013

Maturity-onset diabetes of young 5 (MODY5) with Gallbladder duplication cyst: a novel case

Subbarayan Anbezhil , Kendall Deborah

Maturity-onset diabetes of young 5 (MODY5) is a type of monogenic diabetes involving multiple organs including pancreas and kidneys. This is caused by mutation/deletion of the hepatocyte nuclear factor-1β (HNF-1β) gene located in the chromosome region 17q12.We report a 10-year-old, non-obese girl who was diagnosed with diabetes with features of insulin resistance. She was found to have a heterozygous whole gene deletion of HNF-1&#9...

ea0033oc4.3 | Oral Communications 4 | BSPED2013

The incentive trial: do financial rewards improve glycaemic control in teenagers with poorly controlled type 1 diabetes?

Frerichs Carley , Thomas Douglas , Randell Tabitha

Introduction: Adolescence is recognised as a period where compliance to diabetes treatment is challenging and adolescents assume increasing responsibility for their diabetes self-management. In this study we investigated whether giving modest financial rewards motivated teenagers with type 1 diabetes to improve glycaemic control.Methods: Population; young people with type 1 diabetes, age 13–16 years at entry, duration of diabetes of >2 years and...

ea0033oc4.4 | Oral Communications 4 | BSPED2013

Special features of neonatal diabetes in a series of Arab patients from the Gulf region

Deeb Asma , Abiary Mohamed , Attia Salima , Osman Amani , Flanagan Sarah , Ellard Sian

Advances in molecular genetics revealed various causes for neonatal diabetes (ND) Wider clinical awareness led to recognition of different phenotypes. In areas like the Gulf, it is expected that the incidence of ND to be higher due to the high frequency of consanguinity. The different ethnic background might result in different causes and phenotypes of ND compared to data reported from the west.We report 19 patients from 11 families with ND. All patients...

ea0033oc4.5 | Oral Communications 4 | BSPED2013

Peer Review: A tool to improve Paediatric Diabetes services

Agwu J Chizo , Broomhead Sarah , Eminson Jane , Scanlon John , Kershaw Melanie , Rafeeq P , McCrea Katherine

Peer Review programmes (PRP) help organisations to improve the quality of clinical services in a developmental and supportive way. The West Midlands Paediatric diabetes network (WMPDN) consists of 15 National Health Service (NHS) Trusts looking after 2800 children (aged 0–18 years). 2010/2011 National Paediatric diabetes audit (NPDA) data showed that the median HBA1c achieved in the region was 69 mmol/mol. In order to improve the metabolic control and quality of care, the...

ea0033oc4.6 | Oral Communications 4 | BSPED2013

Increased urinary megalin and cubulin excretion in children with type 1 diabetes mellitus: an association with low molecular weight protein loss

Sirka Ernestas , Manwaring Victoria , Peters Catherine , Amin Rakesh , Heywood Wendy , Hindmarsh Peter , Mills Kevin

Nephropathy remains a major diabetes related complication despite improvements in metabolic control. Current interventions are based on the appearance of albuminuria. Whether earlier detection and treatment might be beneficial is unclear. The reabsorption of low molecular weight (<70 kDa) plasma proteins in the renal proximal tubule is mediated by an endocytic receptor, megalin, and its coreceptor, cubulin.Using label free quantitative proteomics we ...