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16th European Congress of Endocrinology

Oral Communications

Diabetes and Obesity 2

ea0035oc11.1 | Diabetes and Obesity 2 | ECE2014

Inhibition of cardiac dysfunction in diabetic mice by treatment with brain natriuretic peptide

Jankowski Marek , Plante Eric , Gutkowska Jolanta

Aims/hypothesis: Obesity and diabetes enhance the risk of developing cardiovascular diseases and heart failure. These metabolic disorders are generally reflected by natriuretic peptides system deficiency. Since brain natriuretic peptide (BNP) is known to influence metabolism and cardioprotection, we investigated the effect of chronic exogenous BNP treatment on adverse myocardial consequences related to obesity and diabetes.Methods: Ten-week-old C57BL/KsJ...

ea0035oc11.2 | Diabetes and Obesity 2 | ECE2014

An audit of the management of inpatient glycaemia using point of care testing data at Manchester Royal Infirmary

Mitchell Adam , James Emma , Jackson Nicola , Rutter Martin

Background: Suboptimal glycaemic control in hospital inpatients is related to poor clinical outcomes and longer hospital stay. The aims of this study were to document the prevalence and severity of hypo- and hyperglycaemia in medical inpatients and to evaluate aspects of patient management and staff proficiency regarding glucose management.Methods: We performed a retrospective review of 21 381 capillary blood glucose results in 1496 unique patients on 26...

ea0035oc11.3 | Diabetes and Obesity 2 | ECE2014

Improvement or stabilization of retinopathy and visual acuity after islet transplantation: a 5-year prospective study

Vantyghem Marie-Christine , Quintin Delphine , Labalette Pierre , Kerr-Conte Julie , Pattou Francois

This study describes the evolution of retinopathy 5 years after islet transplantation (IT) with the Edmonton protocol in type 1 diabetic patients. Before IT and then yearly for 5 years, 21 patients (13 islet-alone (ITA), 8 islet-after-kidney (IAK)) underwent monitoring of laboratory parameters, continuous 24 h mean blood pressure (24h BP) and 72 h glucose (CGM), as well as complete ophthalmologic examination. Ten of the 21 patients (48%) were insulin-independent 5 years post-I...

ea0035oc11.4 | Diabetes and Obesity 2 | ECE2014

A novel adult human adipose stem cell model from inducible brown fat surrounding pheochromocytoma tumors

Di Franco Alessandra , Guasti Daniele , Mazzanti Benedetta , Ercolino Tonino , Nesi Gabriella , Bani Daniele , Forti Gianni , Mannelli Massimo , Valeri Andrea , Luconi Michaela

The recent discovery of the presence of brown adipose tissue (BAT) also in human adults is pivotal for development of anti-obesity therapies. This type of fat, in fact, mainly consists of brite cells (brown adipocytes appearing for a browning process in white fat) which are involved in adiposity control. The origin of brite cells in adult white adipose tissue (WAT) is still unclear as human cell models are lacking.Our study demonstrated the presence of B...

ea0035oc11.5 | Diabetes and Obesity 2 | ECE2014

Lipodystophic laminopathies are characterised by an increased intra/whole abdominal fat ratio with preserved fat/lean mass ratio and hypoleptinemia, in contrast with obese people, compared to controls

Le Mapihan Kristell , Leroy Clara , Ernst Olivier , Vigouroux Corinne , Lion Georges , Le Guillou Anne-Claire , Quintin Delphine , Douillard Claire , Vantyghem Marie-Christine

Introduction: The diagnosis of non-HIV lipodystrophies is challenging, especially since borderline forms with type 2 diabetes have been described (Strickland Diabetes Care 2013).Objective: To identify the most specific anthropometric and biological parameters enabling to differentiate lipodystrophic from obese and control subjects.Methods: This prospective study ( 2009-AO-1169-48) included 94 patients divided in 3 groups ad...