Searchable abstracts of presentations at key conferences in endocrinology
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16th European Congress of Endocrinology

Poster Presentations

Developmental Endocrinology

ea0035p333 | Developmental Endocrinology | ECE2014

Effect of glycemia on sleep indicators for patients with type 1 diabetes mellitus

Darashkevich Ina , Mokhort Tatyana , Tishkovsky Sergey , Nikonova Lola , Lyschik Valery

Study evaluates the impact of glycemia on the parameters of night’s sleep for patients with decompensated type 1 diabetes mellitus (T1DM).Materials and methods: A total of 21 cases with T1DM (HBA1C 8.5%). The monitoring of the average daily glycemia was performed through ‘SGMSGold Medtronik’ (USA) with estimation of average level of glucose (ALG). Patients divided into groups: group A – 10 patients with A...

ea0035p334 | Developmental Endocrinology | ECE2014

Physiological expression of thyroid hormone receptors during zebrafish development and effects of their molecular disruption

Marelli Federica , Persani Luca

Thyroid hormone action defects (THADs) are caused by the defective action of thyroid hormones (THs) through their receptors (TRs). TRs variants (TRα1 or TRβ) are associated with several defects, which depend mainly on the tissue-specific expression of the defective-receptor. One of the most striking manifestations is the deregulation of the hypothalamus–pituitary–thyroid axis (HPT); patients with TRα1-mutations show normal thyroid volume, low T4/T3 and...

ea0035p335 | Developmental Endocrinology | ECE2014

Clinical and molecular profile of patients with gonadal dysgenesis attending tertiary care hospital.

Chauhan Vasundhera , Khurana Madan Lal , Gupta Poonam , Sabir Iram , Ammini A.C

Introduction: Gonadal dysgenesis (GD) is a congenital disorder which results in defective development of gonads. GD may be due to mutation(s) in any of the genes involved in gonadal development and differentiation. Here we present clinical and molecular profile (SRY and SOX9 gene) of patients with GD at our hospital.Methodology: Detailed clinical examination, karyotyping and molecular analysis of patients was done for SRY and SOX9 gene....

ea0035p337 | Developmental Endocrinology | ECE2014

Crystal structure of Drosophila imaginal morphogenesis protein-Late 2 (IMP-L2) in free form and bound to Drosophila insulin-like peptide 5 (DILP5) and human Insulin-like growth factor-I (hIGF1).

Kulahin Nikolaj , Watson Christopher J. , Sajid Waseem , Schluckebier Gerd , Kristensen Claus , Andersen Asser Sloth , Kristensen Ole , Norrman Matthias , Meyts Pierre De , Brzozowski Andrzej Marek

The insulin signalling system including the insulin receptor tyrosine kinase (IRTK) is evolutionarily ancient. The Drosophila Melanogaster genome contains seven genes for insulin-like peptides (ILPs) that are expressed in neurosecretory cells in a highly tissue- and stage-specific pattern, DILP1–7. There is however only one IRTK (dIR). This system is important in the regulation of metabolism, growth, reproduction and lifespan. We reported in 2011 the crystal stru...

ea0035p338 | Developmental Endocrinology | ECE2014

Genome-wide survey for clinically relevant structural abnormalities contributing to pathogenesis of combined pituitary hormone deficiency (CPHD) with childhood onset.

Budny Bartlomiej , Rydzanicz Malgorzata , Szymczak Klaudia , Szkudlarek Malgorzata , Wolinski Kosma , Wrotkowska Elzbieta , Baszko-Blaszyk Daria , Goleb Monika , Bednarczuk Tomasz , Ambroziak Urszula , Niedziela Marek , Obara-Moszynska Monika , Rabska Barbara , Derebecka Natalia , Bluijssen Hans , Wesoly Joanna , Ruchala Marek , Ziemnicka Katarzyna

Introduction: Combined pituitary hormone deficiency (CPHD) results in deficit of growth hormone and coexisting failure of synthesis or excretion at least another pituitary hormone. Transcription factors controlling expression of genes required for pituitary organogenesis are orchestrating entire development process and certain cell lineages differentiation, contributing therefore significantly to CPHD pathogenesis with childhood onset.Aims: The purpose o...

ea0035p339 | Developmental Endocrinology | ECE2014

Influence of growth hormone therapeutic supplementation on early hematopoietic stem/progenitor cells in patients with growth hormone deficiency (GHD).

Kawa Milosz , Stecewicz Iwona , Pius-Sadowska Ewa , Paczkowska Edyta , Piecyk Katarzyna , Gawrych Elzbieta , Petriczko Elzbieta , Walczak Mieczyslaw , Machalinski Boguslaw

Objectives: GH plays a crucial role in the regulation of metabolism of human cells. Nevertheless, a direct influence of this hormone on the proliferation, maturation and differentiation of human early hematopoietic stem/progenitor cells (HSPCs) has not been investigated thoroughly. Moreover, certain deviations of hematological parameters, such as anemia or leucopenia, are commonly observed in patients with growth hormone deficiency (GHD) syndrome, which might be substantially ...