ECE2014 Poster Presentations Thyroid (non-cancer) (125 abstracts)
Introduction: Serum and intranodal levels of IGF1 and IGF-binding protein 3 levels (IGFBP3) were determined in patients with nodular thyroid diseases.
Materials and methods: Demographic, clinicopathological and laboratorial caracteristics of the subjects were recorded. After performing fine needle aspiration biopsy, IGF1 and IGFBP3 levels were determined in blood and aspiration samples. Clinicopathological and laboratorial findings were analysed.
Results: The serum levels of IGF1 (232.8±12.9 ng/ml) and IGFBP-3 (4.8 μg/ml (2.26.4)) were found significantly higher than intranodal (IGF1 39.1 ng/ml (32.649.8); IGFBP3 0.173 μg/ml (0.070.64)) levels (P<0,01). A positively correlation between serum levels of IGF1 and intranodal levels of IGF1 were observed (P<0.01, r=0.42). Serum level of IGF1 of women patients were found significantly higher than men (P=0.028). The ratio of differentiated thyroid cancer in all cases was 3.75%, and it was 23% in operated patients. Intranodal levels of IGF1 and IGFBP3 in subjects with multinodularities were higher than in cases with single nodules (P=0.043). A positive correlation between the nodular sizes and the serum levels of IGFBP3 was detected (P=0.042, r=0.23).
Conclusions: The pathogenetic clues of thyroid nodules include the increased sizes and multinodulations of the thyroid nodules in this study. These data indicate that both IGF1 and IGFBP3 play an important role in the mitogenic signalling in thyroid nodules.