Background: We know that lipid profile is disturbed in both subclinical hypothyroidism (SH) and metabolic syndrome (MetSy). In this study we observed lipid profile in newly diagnosed patients with SH and MetSy.
Materials and methods: We chose 70 patients (all females) with newly discovered SH and 20 healthy controls, mean age 51.1 (±6.79). The parameters that we determined are: TSH, FT4, anti-TPO-At, triglycerides, whole, LDL and HDL cholesterol. For statistical calculations we used EXCEL, Med-Calc and SPSS Programs.
Results: The patients were additionally divided in two subgroups, considering existence of type 2 diabetes mellitus (DM), one with and the other without DM.The patients had higher levels of whole and LDL cholesterol than the control group (P=0.02). The levels of triglycerides had no difference between groups. The percentage of women with level of HDL cholesterol lower than 1.29 mmol/l is almost the same in the three groups (P=0.953). The percentage of women with level of triglycerides higher than 1.69 mmol/l is statistically significant between three groups (P=0.01). The highest percentage with high triglycerides is in the group of patients with SH and DM (66.7%), while the lowest is in the control group (20%). We didnt find correlation between TSH, FT4 and antiTPO-At and levels of triglycerides and cholesterol.
Conclusion: Considering the results of this study we may conclude that the patients with SH and MetSy has a higher risk for developing of coronary disease and hypertension.